The widespread use of Artabotrys aurantiacus in traditional medicine for the quest for well-being aroused attention for its potential risk to human and animal health. This study points out the acute and sub-chronic toxicological profile of Artabotrys aurantiacus leaves aqueous extract. The extract was prepared following the traditional healer’s method and orally administered to Wistar rats at a single dose of 5000 mg/kg or 50, 100, 200 and 400 mg/kg/day for 45 days for acute and sub-chronic tests, respectively. In acute toxicity, no behavioral disorder was observed in treated animals as compared to the control. The lethal dose of 50 was estimated to be higher than 5000 mg/kg and the extract was noted as slightly toxic. Similarly, no significant change in body weight nor biochemical parameters were observed after 45 days of repeated dosing of the extract. Histological study revealed that all tested doses induced no damage to the liver and kidney as compared to control. These findings indicate that the use of Artabotrys aurantiacus leaves aqueous extract at tested doses is not associated with any toxic effect.
R. Jahns, V. Boivin, C. Siegmund, G. Inselmann, M. Lohse, and F. Boege. Circulation, 99 (5):
649-54(February 1999)Jahns, R Boivin, V Siegmund, C Inselmann, G Lohse, M J Boege, F Research
Support, Non-U.S. Gov't United states Circulation Circulation. 1999
Feb 9;99(5):649-54..
R. Jahns, V. Boivin, C. Siegmund, F. Boege, M. Lohse, and G. Inselmann. J Am Coll Cardiol, 34 (5):
1545-51(November 1999)Jahns, R Boivin, V Siegmund, C Boege, F Lohse, M J Inselmann, G Research
Support, Non-U.S. Gov't United states Journal of the American College
of Cardiology J Am Coll Cardiol. 1999 Nov 1;34(5):1545-51..
Y. Chiu, L. Chen, C. Chan, D. Liou, S. Wu, H. Kuo, H. Chang, and T. Chen. International journal of medical informatics, 75 (5):
369-383(May 2006)M3: Article; Accession Number: 20527463; Chiu, Yueh-Hsia 1,2 Chen, Li-Sheng 1 Chan, Chang-Chuan 3 Liou, Der-Ming 1 Wu, Shiao-Chi 4 Kuo, Hsu-Sung 1 Chang, Hong-Jen 5 Chen, Tony Hsiu-Hsi 6; Email Address: stony@episerv.cph.ntu.edu.tw; Affiliation: 1: Institute of Public Health and Institute of Health Informatics and Decision Making, National Yang-Ming University, Taipei, Taiwan 2: Health Bureau of Keelung City, Keelung City, Taiwan 3: Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan 4: Institute of Health and Welfare Policy, National Yang-Ming University, Taipei, Taiwan 5: Department of Health (DOH), Executive Yuan, Taiwan 6: Institute of Preventive Medicine, College of Public Health, National Taiwan University, Room 207, 2F No. 19, XuZhou Road, Taipei 100, Taiwan; Source Info: May2006, Vol. 75 Issue 5, p369; Subject Term: MEDICAL screening; Subject Term: MEDICAL informatics; Subject Term: CANCER; Subject Term: CHRONIC diseases; Subject Term: COST effectiveness; Subject Term: ELECTRONIC information resources; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 15p; Document Type: Article.