We describe how innate and adaptive immune cascades trigger the release of cytokines and chemokines, resulting in the initiation and progression of atherosclerosis. We discuss how cytokines have direct and indirect effects on myocardial function.
Atherosclerosis is the predominant underlying pathology of cardiovascular disease...atherosclerotic lesions are characterized by abundance of immune cells and their effector molecules, eventually leading to unstable angina, myocardial infarction, or strok
The cellular and extracellular matrix accumulations that comprise the lesions of atherosclerosis are driven by local release of cytokines at sites of predilection for lesion formation, and by the specific attraction and activation of cells expressing rece
S. Stork, V. Boivin, R. Horf, L. Hein, M. Lohse, C. Angermann, and R. Jahns. Am Heart J, 152 (4):
697-704(October 2006)Stork, Stefan Boivin, Valerie Horf, Rudiger Hein, Lutz Lohse, Martin
J Angermann, Christiane E Jahns, Roland Research Support, Non-U.S.
Gov't United States American heart journal Am Heart J. 2006 Oct;152(4):697-704..
V. Nikolaev, A. Moshkov, A. Lyon, M. Miragoli, P. Novak, H. Paur, M. Lohse, Y. Korchev, S. Harding, and J. Gorelik. Science, 327 (5973):
1653-7(March 2010)Nikolaev, Viacheslav O Moshkov, Alexey Lyon, Alexander R Miragoli,
Michele Novak, Pavel Paur, Helen Lohse, Martin J Korchev, Yuri E
Harding, Sian E Gorelik, Julia 084064/Wellcome Trust/United Kingdom
Biotechnology and Biological Sciences Research Council/United Kingdom
Medical Research Council/United Kingdom Research Support, Non-U.S.
Gov't United States Science (New York, N.Y.) Science. 2010 Mar 26;327(5973):1653-7.
Epub 2010 Feb 25..