The clinical effect of electroconvulsive therapy (ECT) has been confirmed for a majority of patients with several psychiatric disorders. ECT is mostly used in patients with severe depression.
Choosing, persevering with and completing ECT depends on the patients' motivation for undergoing this therapy. However, the factors influencing patients' motivation for ECT have not yet been studied. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Intuitively, it makes sense for researchers to be investigating how effective digital mental health support is for a technology-savvy generation. Long waiting lists show that the need for more accessible interventions is there, but these findings indicate that current internet-delivered interventions may not be effective enough to meet this need.
Personality traits underlying both anxiety disorders and depression are more malleable than previously presumed. This study examined associations between changes in personality traits (i.e. negative affectivity and detachment) and alleviation of anxiety and depression symptoms following cognitive behaviour therapy (CBT).
The 2019 coronavirus (COVID-19) pandemic led to elevated levels of psychological distress on a global scale. Given that individuals with pre-existing physical conditions are at risk for worse COVID-19 outcomes, those dealing with the stress of physical health problems (including knowing someone with health problems) may experience more severe distress during the pandemic. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study aimed to investigate whether separation anxiety (SA) constitutes a dimension related to age at onset of panic disorder (PD), in homogeneous subgroups of outpatients with PD, based on their age of onset and symptom severity.
Previously improving UK mortality trends stalled around 2012, with evidence implicating economic policy as the cause. This paper examines whether trends in psychological distress across three population surveys show similar trends. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The provision of cCBT through the NHS could help some young people who need support for anxiety and depression to access the treatment they need more easily. This could be of particular benefit to young people who would not otherwise be able to access traditional face-to-face therapies or who would prefer something remote. However, this review makes it clear that the evidence base for cCBT is currently weak and that high-quality future research is needed, so caution needs to be taken by practitioners before recommending cCBT programs.
Despite limitations, the findings from this study have important clinical and research implications for treating adolescent depression.
For clinicians, it may be beneficial at the beginning of a case of treatment for adolescent depression to develop a set of personalised outcome goals with the patient, with recognition that this is likely to vary greatly between individuals. Treatment could then be jointly chosen by the patient and clinician to ensure these priorities are addressed. This approach could also take into account what the patient thinks their key problem areas are, and what they consider to be valuable improvements. This would also provide a good framework when reviewing clinical decisions of whether to continue or change treatments.
By investigating parents’ depression and how it can be associated with children’s emotional difficulties, this study showed that if untreated, mental ill-health can have significant long-lasting effects on the mother, father and children.
As this study points out, the activating and associating depressive symptoms between family members can be targeted for more rapid recovery, and may be key to identifying who might be more at risk of developing depression in young children, and later unintentionally influencing the transmission of depression.
Overall, this research brings to light many ways in which access can be improved. However, as the authors mention, it is important to keep in mind that the process of improving access is not a “one size fits all” approach. Instead, programs that aim to improve access should carefully consider their target audience and combine a variety of complementary strategies. In conclusion, the authors talk about practice guidelines. They suggest that each category of healthcare providers would benefit from specific guidelines on improving access to CBT through their specific roles.
Childhood emotional maltreatment (CEM) is a risk factor for the pathogenesis of depressive disorders. However, it is not clear whether CEM is more strongly related to specific symptoms of depression and whether specific traits or cognitive states may mediate the association between CEM and depressive symptoms. In our cross-sectional study, including 72 patients with a current depressive episode, we investigated if CEM is specifically related to cognitive symptoms of depression.
This study used structural equation modelling to test the prediction that intolerance of uncertainty and emotion regulation constitute more direct causes of anxiety in autism that mediate the influences of sensory processing difference and alexithymia as more sequential contributing factors. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
No previous studies have reported predictors and moderators of outcome of psychological therapies for depression experienced by adults with intellectual disabilities (IDs). We investigated baseline variables as outcome predictors and moderators based on a randomised controlled trial where behavioural activation was compared with guided self-help. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
To manage ‘treatment-resistant depression’, research has demonstrated that a multidisciplinary approach should be utilised (i.e., administration of medication as well as psychological support). In the current study, psilocybin was administered during a single session of psychological support. More research needs to be conducted to investigate the effectiveness of using psilocybin alongside a course of psychological support (e.g., Cognitive Behavioural Therapy).
The findings suggest the involvement of both innate and adaptive immune cells in the development of depression.
Identifying dysfunctional immune cell subsets could help select patients with depression who show signs of immune dysfunction for future immunotherapy trials. However, further studies are needed to understand causality and how immune cell dysfunction relates to cytokine and neurotransmitter dysregulation.
The review showed that robust evidence for the effectiveness of iCBT as an add-on to TAU is still limited, with results not necessarily generalisable to people from different backgrounds based on age, gender, education, and mental healthcare settings. Clearly more research is needed, as remotely delivered, self-guided iCBT has the promise to increase accessibility and be more cost-effective.
Postpartum depression (PPD) is a common perinatal complication with adverse maternal and infant outcomes. This study investigated the efficacy and safety of zuranolone, a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors and neuroactive steroid, as an oral, once-daily, 14-day treatment course for patients with severe PPD. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Gaining awareness of psychosis (i.e., insight) is linked to depression, particularly in the post-acute phase of psychosis. Informed by social rank theory, we examined whether the insight–depression relationship is explained by reduced social rank related to psychosis and whether self-compassion (including uncompassionate self-responding [UCS] and compassionate self-responding [CSR]) and mindfulness buffered the relationship between social rank and depression in individuals with first episode psychosis during the post-acute phase.
Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Hospitalization is a stressful event that may lead to deterioration in older adults’ mental health. Drawing on the stress-buffering hypothesis, we examined whether family support during hospitalization would moderate the relations between level of independence and in-hospital depressive symptoms.
To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Depression and anxiety are common, with one in six people experiencing symptoms in any given week. Of these people, 8.32 million are prescribed antidepressants. People living with HIV are likely to experience psychiatric disorder, with one in three experiencing depression and anxiety, and being at greater risk of developing post-traumatic stress disorder... This article seeks to raise awareness of sexual side-effects of psychotropic medications and draw attention to ethical issues related to post selective serotonin reuptake inhibitor sexual dysfunction (PSSD)
To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Difficulties regulating emotions during periods of distress may contribute to the high rates of co-occurring depression and anxiety in autistic adults. The emotional support plan (ESP) is a brief intervention designed to support autistic adults to use positive coping skills during periods of distress. Thirty-six autistic adults participated in studies to assess the acceptability of the ESP intervention... To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Some anxiety disorders may improve or remit without intervention, meaning a brief period of ‘watchful waiting’ may be prudent in certain situations
Specific phobia and panic disorder with agoraphobia do not show signs of improving without intervention, meaning that treatment should be provided as soon as possible for individuals with these conditions.
It’s worth commenting on the finding that only 15% of control participants experienced ‘clinically meaningful’ improvements in their anxiety, meaning 85% will still experience symptoms of anxiety. For those whose anxiety does not improve significantly or remit, this waiting period will not be a neutral limbo – it may be a highly difficult and distressing time for them, and this must be taken into account when considering the implementation of such findings.
If we have a better understanding of how anxiety and depression may develop over the course of childhood and adolescence, and who may be at greatest risk of adverse outcomes in adulthood, this may inform targeted early identification and prevention strategies. The authors suggest that this could beneficially impact policy and practice at certain touchpoints, such as the transition from children’s to adult’s mental health services, which has been highlighted by previous studies as an “international concern” due to the consequences of lack of continuity of care (Hendrickx et al., 2020 p. 163).
Individuals with major depressive disorder (MDD) and childhood maltreatment have been proposed to constitute a subgroup with worse illness course and outcomes. To elucidate a potential social cognitive vulnerability in this subgroup, this study compared the emotion decoding abilities of MDD patients with and without a history of childhood maltreatment.
Bouldering psychotherapy (BPT) for depression has proven effective, but nothing is known about its potential predictors of response. This study should identify predictors of response to BPT, cognitive behavioural therapy (CBT) and an active control (home-based exercise programme; EP) using a literature-based model.
Predicting the course and complications of perinatal depression through the identification of clinical subtypes has been previously undertaken using the Edinburgh Postnatal Depression Scale and has the potential to improve the precision of care and improve outcomes for women and their children. https://onlinelibrary.wiley.com/doi/10.1002/cpp.2893?af=R
Although this study suggested that long-term psychoanalytic psychotherapy in combination with treatment as usual was not cost-effective compared with TAU, there may be more explanations to this. Given the sustained long-term effects over the follow-up period and the trajectory of treatment benefits in the LTPP+TAU group, it seems plausible that the timescale of this study was too short to accurately portray the long-term benefits of LTPP.
The International Anxiety Questionnaire (IAQ) and International Depression Questionnaire (IDQ) are self-report measures of ICD-11 Generalized Anxiety Disorder (ICD-11 GAD) and ICD-11 Single Episode Depressive Disorder (ICD-11 DD). This study tested the psychometric properties of these scales in two samples of bereaved adults from the United Kingdom and the Republic of Ireland.
Dysfunctional attitudes (DA) are higher in depression; however, less is understood about their role in bipolar disorder (BD). This paper aimed to explore the presence of DA in BD in comparison to clinical and non-clinical groups. Also explored were the associations between DA and mood states of depression, mania or euthymia in BD.
This cross-sectional study aims to systematically assess and compare parenting stress in families of children with various types of disabilities. Open access article - no login required
The primary goal of this study was to examine the feasibility and effectiveness of incorporating habit training into an app-based meditation intervention to maintain reductions in depressive symptoms among autistic adults. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This meta-analysis is very relevant for those working within mental health services and delivering mental health interventions with clients or community members. It suggests that transdiagnostic mental health interventions should be considered as an effective way of treating anxiety and depression, at least in the short term, as they might have an edge over other treatments, especially when treating co-morbidity or mixed anxiety and depression symptoms.
Patients showed a stronger preference for CAT-GSH, compared to CBT-GSH, and CAT-GSH participants were found to be more likely to complete full treatment. However, findings seem to indicate that preference accommodation did not have an impact on clinical outcomes, and the two GSH versions evaluated were found to be equally effective treatment options for the treatment of anxiety. Hence, CAT-GSH may represent an effective and well-tolerated option that could be offered to anxious patients in primary care settings.
The study reinforces findings from the existing literature that, in the context of comorbid anxiety and depression, anxiety seems to have an earlier age of onset. Early identification and intervention for anxiety disorders may therefore help to prevent the developmental of other comorbid psychiatric disorders, such as depression or additional anxiety disorders.
This review concluded that people living with depression are at considerable risk of internalising negative stereotypes and discrimination associated with depression. Prominent risk factors were identified, including depression symptom severity and stigma-related factors; but protective factors were also identified, such as quality of life and self-esteem.
The authors of the study conclude that “KAT offers clinically meaningful improvements and demonstrated a desirable safety and risk mitigation profile”. Ongoing ketamine-based medication sessions enhance therapeutic benefits by preventing the 90% relapse rate that is often seen in single-infusion ketamine-based treatments (Kryst et al., 2020).
Hull et al. (2022) take this standpoint to reiterate the use of dissociative and psychedelic compounds for reducing important symptoms of common mental health disorders such as reducing suicidal ideation and behaviour. This could be viewed as an exaggeration, especially since the mechanism of dissociation is still relatively unknown in terms of how it reduces anxiety and depression symptoms (Liu et al., 2020).
This qualitative systematic review shows that antidepressants might not always help depression. For this patient population, it may be important for health professionals to work with patients to explore other treatments for managing their depression. Treatment could include cognitive behavioural therapy, which was shown in a systematic review to be an effective intervention for TRD at short-term, mid-term, and long-term follow-up (Li et al., 2018).
Several useful points for clinicians emerge from this paper. The first-hand experiences compiled here reveal some common experiences among people living with depression which are not reflected in diagnostic criteria or checklists for lay people. While sleep, weight and appetite disturbances are noted in the latest edition of the Diagnostic and Statistical Manual of Mental Disorders as indicative of depression, this paper suggests that the somatic nature of the depressive experience is more pronounced than this. Experiences such as aches and pains, a sense of heaviness, and a body that lacks physical energy may be important markers of depression, and it is therefore unhelpful to view the mind and body as separate. The importance of fatigue has also been stressed by adolescents experiencing depression
Prevention of new depressive disorders is very much needed because current treatments can only reduce the disease burden of depression to a limited extent.
Research has shown that preventive interventions are effective, especially in indicated prevention, but also selective prevention. However, the impact of these interventions is limited because the uptake is low.
A new generation of randomized community trials are needed to examine suites of innovative preventive interventions.
In this blog I will give a brief overview of this field, and what can be done to further improve the effects of these treatments. I have also presented a more extensive overview in the webinar that you can watch below.
Concludes that there is little uptake of psychological interventions for depression. Strategies currently in development that could change this include single session interventions and task sharing which involves using lay counsellors to deliver the intervention. Digital interventions could improve access to treatment and have shown some positive outcomes.
This item explores adolescents’ use of social media to manage stress and loneliness at a time of restricted social contacts due to the COVID-19 pandemic. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The current study investigated the association between paternal postnatal depressive symptoms and parenting behaviours. Open access article - no login required.
The identified relationship between parental mood disorders and offspring anxiety disorders provides valuable insights that mental health practitioners can integrate into their practice. Understanding these risk factors and underlying mechanisms aids mental health professionals in tailoring treatments and interventions according to the family background and specific needs of their clients.
This meta-analysis evaluated the relationship between overweight/obesity and depressive disorders in children and adolescents. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
To determine the treatment effect of resistance training in reducing symptoms of anxiety and depression in young people. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study aims to examine the associations between social capital derived from online versus in-person networks and mental health indicators among gamers. Open access article - no login required
...the paper seeks to clarify distinctions between: (i) threat detection and response, (ii) safety and safety seeking, (iii) safeness and (iv) their social and non-social functions and forms. Open access article - no login required
This meta-analysis estimates the effects of patient preference on clinical outcome, satisfaction and adherence regarding treatment of depression and anxiety. Open access article - no login required.
This trial found greater intensity of psychotherapy leads to better outcomes of both depression and personality status in people with comorbid depression and personality disorder. Open access article - no login required.
Clinical practice with young children benefits from knowledge about the prevalence of depressive disorders in childhood and that the well-established sex differences seen for depression in adulthood may not appear until adolescence.
Further research is needed to address possible changes in the prevalence of childhood depressive disorders around the world and following the COVID-19 pandemic, and whether these changes are differentially distributed across individuals and communities.
To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Implications for practice and research:
Providers should encourage antidepressant use with statins for depression that is comorbid with physical conditions.
Research can clarify which population subgroups taking both medications demonstrate improved outcomes.
To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Online symptom checkers are a way to address patient concerns and potentially offload a burdened healthcare system. However, safety outcomes of self-triage are unknown, so we reviewed triage recommendations and outcomes of our institution's depression symptom checker.
To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This systematic review and meta-analysis evaluates the possibilities and effects of imagery-based interventions that explicitly target negative images in (sub)clinical social anxiety. Open access article - no login required.
This paper aims to provide insights about why Deaf people are twice as likely as hearing people to experience mental health problems. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
...focussing on the lived experiences of regional Australian youth with recent experience of climate-related disasters alongside clinical insights from those involved in their care. Open access article - no login required.
The objective of this study was to perform a well-powered genetic study of TRD. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
We are a large and diverse group of national and international clinicians, lived experience and social community advocates, all working together to innovate the current approaches available for women with menopausal mental ill health. Open access article - no login required.
The current study employed network analytic techniques to examine how subjective views surrounding the cause of depressive symptoms altered actual symptom presentation networks. Additionally, the interaction between depressive symptoms and various etiological beliefs was examined. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The goal of the current research was to clarify the mixed findings regarding the relation between pleasure deficits and internalizing psychopathology. Open access article - no login required.
As cannabis policies become more permissive, there is a reasonable concern that this may increase rates of CUD and contribute further to the incidence of other mental health disorders. However, several strategies can be implemented to offset these harms.
This study, from Australia, examines associations between becoming a caregiver and depressive symptoms among men. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study, from Sweden, finds adult children of parents with AUD have a raised risk of mood and anxiety disorders even after adjustment for sociodemographic factors and parental mood or anxiety disorder. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The authors sought to assess the prosocial, entactogen effects of ketamine. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The authors compared the associated risk of incident depression between first-time users of low-, medium-, and high-dose levonorgestrel-releasing intrauterine systems (LNG-IUSs). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The authors performed a target trial emulation to compare the risk of mania among individuals with bipolar depression treated or not treated with antidepressants over a 1-year period. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
We conducted a systematic review to provide a comprehensive overview of the empirical research on the bidirectional temporal associations between prolonged grief symptoms and symptoms of depression, posttraumatic stress, and anxiety. Open access article - no login required
Despite the widespread use and perceived efficacy of cannabidiol (CBD) as an anxiolytic, few controlled studies have evaluated the effects of CBD on anxiety-relevant indications, and only one has done so in the context of trauma-related symptoms. The current study was designed to address this gap in the literature. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The current study aims to examine the efficacy of CBT delivered via videoconferencing (VCBT) for GAD using a randomized controlled trial design comparing an immediate treatment group to a waitlist control. Open access article - no login required
...little is known about the experience of intrusive cognitions in adolescents, particularly in adolescents with major depressive disorder (MDD) and post-traumatic stress disorder (PTSD). The present study sought to gather fundamental data on these phenomena (i.e., frequency, characteristics and appraisals of intrusive cognitions) in adolescents with MDD and PTSD. Open access article - no login required
This study examines psychological, social and environmental risk and protective factors that may explain changes in depression and anxiety among adolescents. Open access article - no login required
Study of the effects of psychoanalytic therapy versus cognitive–behavioural therapy for chronic depression in adults with a history of childhood trauma. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
In this multicenter randomized controlled trial, rTMS was compared with the next pharmacological treatment step in patients with treatment-resistant depression. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Children born to parents with a mental illness have been shown, over and over again, to be at an increased risk of developing mental health problems early in life. A recent comprehensive meta-analysis that gathered data from all over the world, including data from 3 million individuals at familial risk and 20 million control individuals, left no doubt about the increased risk... To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
...emphasizing the necessity of scrutinizing anxiety theory against larger data sets... To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
'It remains staggering that the patients that might need psychological therapy the most, i.e. patients with high risk for suicidality remain excluded from most of the trials. This limits the insights into the effectiveness of most common offered interventions in daily clinical practice on suicidality.'
This study reports on young people's session experiences over time and by key demographics for headspace youth mental health services. Open access article - no login required
Study found that a digitally augmented psychological therapy with therapist support could be as effective as normal treatment. This has cost and resource implications.
We report the effect of quality of therapy delivery on outcomes in a randomized, controlled trial of behavioural activation (BA) and guided self-help (GSH) for depression in adults with intellectual disabilities. Open access article - no login required
This study tested two hypotheses: (a) that there were significant group-level associations between post-ECT clinical outcomes and pre-ECT clinical variables and (b) that it was possible to develop a method for predicting illness remission for individual patients using machine learning. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
T. Itatsu, A. Nagahara, M. Hojo, A. Miyazaki, T. Murai, M. Nakajima, и S. Watanabe. Internal medicine (Tokyo, Japan), 50 (7):
713-7(января 2011)JID: 9204241; 0 (Serotonin Uptake Inhibitors); 2011/04/01 epublish; ppublish; Confusió absoluta entre cas-control i exposats-no exposats<br/><br/><br/>Tipus d'estudis.