Letter. The recent meta‐analytic review of trials involving anti‐inflammatory agents to treat or to supplement treatment of patients with major depressive disorder (MDD) or depressive symptoms by Köhler‐Forsberg and colleagues [1] includes data derived from 36 controlled trials.
Commentary. Rarely has there been so much anticipation for a new antidepressant as has been seen for intranasal esketamine, the putatively more effective enantiomer of ketamine. This reflects the exposure given to studies on the off-label intravenous use of racemic mixture ketamine for refractory depression and its ensuing availability via ketamine clinics and infusion centers. Intranasal esketamine represents a novel way of administering the agent and is the subject of the report in this issue by Popova et al. (1).. Login at top right hand side of page using your MPFT NHS OpenAthens for full text.
Health Psychology (May 23, 2019). DOI:10.1037/hea0000764
Objective: To investigate the separate and combined associations of obesity and metabolic syndrome (MetS) with depression and the role of inflammation. . To read the full article, log in using your NHS OpenAthens details.
Open access. This randomised controlled trial explored the anti-depressive and health effects of add-on exercise (running therapy or Nordic walking) in patients with Major Depressive Disorder (MDD).
Open access. Abnormalities in heart rate during sleep linked to impaired neuro-cardiac modulation may provide new information about physiological sleep signatures of depression. This study assessed the validity of an algorithm using patterns of heart rate changes during sleep to discriminate between individuals with depression and healthy controls.
Free access. To quantify inequalities in the prevalence of elevated depressive symptoms by rural childhood residence and the extent to which childhood socioeconomic conditions and educational attainment contribute to this disparity.
Interpersonal psychotherapy for adolescents (IPT‐A) is a manualised, time‐limited intervention for young people with depression. This systematic review aimed to determine the effectiveness of IPT‐A for treating adolescent depression.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Anxiety runs in families, and its transmission is largely environmental. However, studies rarely explore this process in clinically anxious parents or ask participants to face a genuine fear. We also do not know whether this process is modifiable. This study will explore these questions using a sample of clinically anxious parents.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
In this Review, we assess this evidence in relation to rheumatoid arthritis and depression, with a focus on innate immune and molecular responses to inflammation, and discuss the challenges of assessing causation in this population, acknowledging the difficulty of assessing the confounding and contributory effects of pain and fatigue. We also discuss how future clinical and preclinical research might improve diagnosis of depression in people with rheumatoid arthritis and shed light on mechanisms that could be substrates for therapeutic interventions.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Reports in the UK media were broadly accurate and balanced, although the headlines didn't make it clear that the study was carried out in mice, not humans.
Letter. In their meta‐analysis, Kohler‐Forsberg and colleagues (1) analyzed the efficacy or rather effect of anti‐inflammatory treatment on major depressive disorder or depressive symptoms. In the discussion of limitations of their meta‐analysis, they briefly mention that “although the antidepressant effects of NSAIDs have been shown to be independent of their pain‐relieving effects, the antidepressant effect of anti‐inflammatory agents may be mediated via their effect on somatic diseases.”..... To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
There is good evidence that job stressors are prospectively related to mental health problems, particularly depressive symptoms. This review aimed to examine whether job stressors were also related to use of psychotropic medications. To read the full article, log in using your MPFT NHS OpenAthens details.
Open access. Depression is usually managed in primary care, but most antidepressant trials are of patients from secondary care mental health services, with eligibility criteria based on diagnosis and severity of depressive symptoms. Antidepressants are now used in a much wider group of people than in previous regulatory trials. We investigated the clinical effectiveness of sertraline in patients in primary care with depressive symptoms ranging from mild to severe and tested the role of severity and duration in treatment response..
Conclusions
Suicidal risks were high in mood disorders: ideation was highest with BD type II, attempts and suicides (especially violent) with BD type I. Several risk factors for suicidal acts differed between BD versus MDD patients.. To read the full article, log in using your MPFT NHS OpenAthens details.
A review investigating dependence and withdrawal issues associated with five commonly prescribed medicines in England has been published by PHE (2019), covering the latest evidence and highlighting patients& experiences.
The findings indicate that antidepressants in particular are being prescribed in much greater numbers and for longer durations, whereas prescriptions of benzodiazepines and opioids have fallen in recent years (PHE, 2019). To read the full article, log in using your MPFT NHS OpenAthens details.
To examine the incidence of suicidal and violent behaviour following initiation of antidepressant medication.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Douglas Badenoch on a meta-analysis of follow-up data from clinical trials of antidepressants, which found a small but significant increase in suicide risk.
Psychological Medicine; Cambridge Vol. 49, Iss. 13, (Oct 2019): 2168-2176. DOI:10.1017/S0033291718002994
Background
It has been proposed that vascular disease is the mechanism linking depression and cognition, but prospective studies have not supported this hypothesis. This study aims to investigate the inter-relationships between depressive symptoms, cognition and cerebrovascular disease using a well-characterised prospective cohort.. To read the full article, log in using your MPFT NHS OpenAthens details.