This is a valuable study that furthers our understanding of the brain changes that may occur before any symptoms of Parkinson's disease develop. However, before concluding that measuring serotonin activity is a way of detecting who's likely to develop Parkinson's, it's important to set this finding in the right context.
For the vast majority of people who develop Parkinson's, the cause is unclear. Families with gene mutations that place them at strong hereditary risk of the condition are very rare.
Many people with parkinsonism require care as the disease progresses with much provided unpaid by family and friends. Caring for someone can have a negative impact on physical and psychosocial wellbeing. Caregiver burden can impact ability to continue this role, which can precipitate hospitalisation or institutionalisation of the recipient. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This commentary is on the original article by Whitney et al. To view this paper visit https://doi.org/10.1111/dmcn.14175.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Tuberous sclerosis complex (TSC) is a complex multisystem genetic disorder. Approximately 84% of people with TSC have epilepsy. However, there is little literature available regarding families' experiences with TSC and seizure management. Therefore, the aim of the current study was to explore families' positive and negative experiences, and attitudes towards TSC, epilepsy and medical management of seizures.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Rehabilitation Psychology (Mar 21, 2019). DOI:10.1037/rep0000273
Objectives: Pain has been identified as a highly prevalent and common correlate of physical and emotional dysfunction among persons with multiple sclerosis (PwMS). Yet, it remains unknown how PwMS experience the intrusiveness of pain relative to other challenges associated with living with MS. This study aimed to determine the extent to which PwMS experience pain as a particularly intrusive problem among the totality of their experience of MS-related challenges and to examine how cognitive and affective factors, including resiliency, are associated with PwMS’s pain-related illness intrusiveness.. To read the full article, log in using your NHS OpenAthens details.