Ex: Managing the Metric vs Managing the Patient: The Physician’s View of Pay for Performance, Inpatient Management Guidelines for People with Diabetes, Reducing Health Care Costs for Plan Members with Congestive Heart Failure...
Bacteria have tiny channels in their walls which operate like the valve on a pressure cooker - they open to release material when the pressure in a bacterial cell gets too great. If the channel didn't open to relieve pressure the bacteria would explode and die, so this is a target for drug development.