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2The galanin receptor type 2 initiates multiple signaling pathways in small cell lung cancer cells by coupling to G(q), G(i) and G(12) proteins
N. Wittau, R. Grosse, F. Kalkbrenner, A. Gohla, G. Schultz, and T. Gudermann. Oncogene, 19 (37): 4199-209 (August 2000)Wittau, N Grosse, R Kalkbrenner, F Gohla, A Schultz, G Gudermann, T England Oncogene Oncogene. 2000 Aug 31;19(37):4199-209..
14 years ago by @pharmawuerz
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1-Methyl-3-isobutylxanthine/pharmacology
1/metabolism
2
3
3T3
AMP/physiology
Actins/metabolism
Adhesion
Animals
Bordetella/pharmacology
C
C/antagonists
COS
Calcium
Carcinoma,
Cell
Cell/metabolism/*pathology
Cells/drug
Cultured/metabolism
Cyclic
Diacylglycerol-Lyase
Enzyme
Factors,
Fusion
G12-G13
GTP-Binding
Galanin
Galanin,
Galanin/metabolism/pharmacology
Gi-Go/*physiology
Gohla
Gq-G11
Heterotrimeric
Humans
Indoles/pharmacology
Inhibitors/pharmacology
Inositol
Intracellular
Isoproterenol/pharmacology
Kinase
Kinases
Kinases/metabolism
Kinases/physiology
Lung
Maleimides/pharmacology
Mice
Microfilaments/metabolism
Mitogen-Activated
Neoplasm
Neoplasms/metabolism/*pathology
Neuropeptide/drug
Peptides
Pertussis
Phosphates/metabolism
Phosphatidylinositol
Phospholipases/metabolism
Protein
Protein-Serine-Threonine
Protein/physiology
Proteins
Proteins/*physiology
Proteins/antagonists
Proteins/genetics/physiology
Recombinant
Signaling
Signaling/drug
Small
Subunits,
Toxin
Transfection
Tumor
Type
Virulence
alpha
and
effects
effects/*physiology
inhibitors/*physiology
inhibitors/physiology
rho-Associated
rhoA
Receptor
&1-Methyl-3-isobutylxanthine/pharmacology1/metabolism233T3AMP/physiologyActins/metabolismAdhesionAnimalsBordetella/pharmacologyCC/antagonistsCOSCalciumCarcinoma,CellCell/metabolism/*pathologyCells/drugCultured/metabolismCyclicDiacylglycerol-LyaseEnzymeFactors,FusionG12-G13GTP-BindingGalaninGalanin,Galanin/metabolism/pharmacologyGi-Go/*physiologyGohlaGq-G11HeterotrimericHumansIndoles/pharmacologyInhibitors/pharmacologyInositolIntracellularIsoproterenol/pharmacologyKinaseKinasesKinases/metabolismKinases/physiologyLungMaleimides/pharmacologyMiceMicrofilaments/metabolismMitogen-ActivatedNeoplasmNeoplasms/metabolism/*pathologyNeuropeptide/drugPeptidesPertussisPhosphates/metabolismPhosphatidylinositolPhospholipases/metabolismProteinProtein-Serine-ThreonineProtein/physiologyProteinsProteins/*physiologyProteins/antagonistsProteins/genetics/physiologyRecombinantSignalingSignaling/drugSmallSubunits,ToxinTransfectionTumorTypeVirulencealphaandeffectseffects/*physiologyinhibitors/*physiologyinhibitors/physiologyrho-AssociatedrhoAReceptor
(0)
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1Interactions between intracellular cyclic AMP and agonist-induced inositol phospholipid breakdown in isolated gastric mucosal cells of the rat
J. Puurunen, M. Lohse, and U. Schwabe. Naunyn Schmiedebergs Arch Pharmacol, 336 (5): 471-7 (November 1987)Puurunen, J Lohse, M J Schwabe, U In Vitro Research Support, Non-U.S. Gov't Germany, west Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 1987 Nov;336(5):471-7..
14 years ago by @pharmawuerz
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AMP/antagonists
Activation/drug
Animals
Bucladesine/pharmacology
C/metabolism
Carbachol/pharmacology
Cimetidine/pharmacology
Cyclic
Dibutyryl
Enzyme
Esters/pharmacology
Forskolin/pharmacology
GMP/pharmacology
Gastric/metabolism
Histamine/pharmacology
Inhibitors/pharmacology
Inositol
Kinase
Male
Parietal
Phorbol
Phosphates/*metabolism
Phosphates/antagonists
Phosphodiesterase
Protein
Pyrrolidinones/pharmacology
Rats
Rolipram
Strains
Sugar
effects
inhibitors/*metabolism
inhibitors/*physiology
Cell
Mice
&AMP/antagonistsActivation/drugAnimalsBucladesine/pharmacologyC/metabolismCarbachol/pharmacologyCimetidine/pharmacologyCyclicDibutyrylEnzymeEsters/pharmacologyForskolin/pharmacologyGMP/pharmacologyGastric/metabolismHistamine/pharmacologyInhibitors/pharmacologyInositolKinaseMaleParietalPhorbolPhosphates/*metabolismPhosphates/antagonistsPhosphodiesteraseProteinPyrrolidinones/pharmacologyRatsRolipramStrainsSugareffectsinhibitors/*metabolisminhibitors/*physiologyCellMice
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2Regulation of phosducin-like protein by casein kinase 2 and N-terminal splicing
J. Humrich, C. Bermel, T. Grubel, U. Quitterer, and M. Lohse. J Biol Chem, 278 (7): 4474-81 (February 2003)Humrich, Jan Bermel, Christina Grubel, Tobias Quitterer, Ursula Lohse, Martin J United States The Journal of biological chemistry J Biol Chem. 2003 Feb 14;278(7):4474-81. Epub 2002 Dec 3..
14 years ago by @pharmawuerz
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Alternative
Animals
Carrier
Casein
Cell
Enzyme
Humans
II
Inhibitors/pharmacology
Kinase
Kinases/antagonists
Line
Mice
Nerve
Organ
Phosphorylation/drug
Protein-Serine-Threonine
Proteins/genetics/*metabolism
Specificity
Splicing
Substrate
Tissue
effects
inhibitors/genetics/*metabolism
&AlternativeAnimalsCarrierCaseinCellEnzymeHumansIIInhibitors/pharmacologyKinaseKinases/antagonistsLineMiceNerveOrganPhosphorylation/drugProtein-Serine-ThreonineProteins/genetics/*metabolismSpecificitySplicingSubstrateTissueeffectsinhibitors/genetics/*metabolism
(0)
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1Regulation of p42/p44 mitogen-activated protein kinase by the human adenosine A3 receptor in transfected CHO cells
S. Graham, P. Combes, M. Crumiere, K. Klotz, and J. Dickenson. Eur J Pharmacol, 420 (1): 19-26 (May 2001)Graham, S Combes, P Crumiere, M Klotz, K N Dickenson, J M Research Support, Non-U.S. Gov't Netherlands European journal of pharmacology Eur J Pharmacol. 2001 May 18;420(1):19-26..
14 years ago by @pharmawuerz
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1-Phosphatidylinositol
1/antagonists
3-Kinase/antagonists
A3
AMP/metabolism
Activation/drug
Adenosine
Adenosine/*analogs
Androstadienes/pharmacology
Animals
CHO
Chromones/pharmacology
Cricetinae
Cyclic
Dose-Response
Drug
Enzyme
Flavonoids/pharmacology
Forskolin/pharmacology
Fusion
Humans
Inhibitors/pharmacology
Kinase
Luciferases/drug
Mitogen-Activated
Morpholines/pharmacology
P1/genetics/*physiology
Phosphorylation/drug
Protein
Proteins/drug
Purinergic
Recombinant
Relationship,
derivatives/pharmacology
effects
effects/genetics/metabolism
inhibitors/*metabolism
inhibitors/metabolism
Receptor
Cell
&1-Phosphatidylinositol1/antagonists3-Kinase/antagonistsA3AMP/metabolismActivation/drugAdenosineAdenosine/*analogsAndrostadienes/pharmacologyAnimalsCHOChromones/pharmacologyCricetinaeCyclicDose-ResponseDrugEnzymeFlavonoids/pharmacologyForskolin/pharmacologyFusionHumansInhibitors/pharmacologyKinaseLuciferases/drugMitogen-ActivatedMorpholines/pharmacologyP1/genetics/*physiologyPhosphorylation/drugProteinProteins/drugPurinergicRecombinantRelationship,derivatives/pharmacologyeffectseffects/genetics/metabolisminhibitors/*metabolisminhibitors/metabolismReceptorCell
(0)
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2Surrogate predictive biomarkers for response to anti-EGFR agents: state of the art and challenges
F. Cappuzzo, L. Toschi, G. Finocchiaro, C. Ligorio, and A. Santoro. Int.J.Biol.Markers, 22 (1 Suppl 4): S10-S23 (2007)
15 years ago by @jabreftest
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inhibitors
Monoclonal
Tyrosine
antagonists
c-akt
Predictive
of
Phosphoproteins
Protein-Tyrosine
Resistance
protein
Drug
Protein
Epidermal
Value
&
Factor
identify
erbB-3
erbB-2
effects
Carcinoma
Neoplasms
Non-Small-Cell
Tests
Biological
therapy
Mutation
therapeutic
Human
Humans
use
analysis
Kinases
response
Growth
Neoplasm
Inhibitors
Markers
Kinase
drug
Gene
Quinazolines
Receptor
genetics
Antibodies
Lung
Dosage
Proto-Oncogene
Proteins
Immunohistochemistry
inhibitorsMonoclonalTyrosineantagonistsc-aktPredictiveofPhosphoproteinsProtein-TyrosineResistanceproteinDrugProteinEpidermalValue&FactoridentifyerbB-3erbB-2effectsCarcinomaNeoplasmsNon-Small-CellTestsBiologicaltherapyMutationtherapeuticHumanHumansuseanalysisKinasesresponseGrowthNeoplasmInhibitorsMarkersKinasedrugGeneQuinazolinesReceptorgeneticsAntibodiesLungDosageProto-OncogeneProteinsImmunohistochemistry
(0)
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1Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib
T. Chu, M. Rupnick, R. Kerkela, S. Dallabrida, D. Zurakowski, L. Nguyen, K. Woulfe, E. Pravda, F. Cassiola, J. Desai and 10 other author(s). Lancet, 370 (9604): 2011-2019 (2007)
15 years ago by @kanefendt
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Aged
Agents
Animals
Antineoplastic
Arteries
Artery
Blood
Carcinoma
Coronary
Disease
Failure
Female
Gastrointestinal
Heart
Humans
Hypertension
Indoles
Kinase
Kinases
Male
Mice
Middle
Multicenter
Pressure
Protein-Tyrosine
Pyrroles
Rats
Research
Retrospective
Safety
Stroke
Stromal
Studies
Topic
Tumors
Tyrosine
Volume
adverse
antagonists
as
blood
chemically
drug
effects
induced
inhibitors
methods
therapeutic
therapy
toxicity
use
&AgedAgentsAnimalsAntineoplasticArteriesArteryBloodCarcinomaCoronaryDiseaseFailureFemaleGastrointestinalHeartHumansHypertensionIndolesKinaseKinasesMaleMiceMiddleMulticenterPressureProtein-TyrosinePyrrolesRatsResearchRetrospectiveSafetyStrokeStromalStudiesTopicTumorsTyrosineVolumeadverseantagonistsasbloodchemicallydrugeffectsinducedinhibitorsmethodstherapeutictherapytoxicityuse
(0)
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2Surrogate predictive biomarkers for response to anti-EGFR agents: state of the art and challenges
F. Cappuzzo, L. Toschi, G. Finocchiaro, C. Ligorio, and A. Santoro. Int.J.Biol.Markers, 22 (1 Suppl 4): S10-S23 (2007)
15 years ago by @kanefendt
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&
Antibodies
Biological
Carcinoma
Dosage
Drug
Epidermal
Factor
Gene
Growth
Human
Humans
Immunohistochemistry
Inhibitors
Kinase
Kinases
Lung
Markers
Monoclonal
Mutation
Neoplasm
Neoplasms
Non-Small-Cell
Phosphoproteins
Predictive
Protein
Protein-Tyrosine
Proteins
Proto-Oncogene
Quinazolines
Receptor
Resistance
Tests
Tyrosine
Value
analysis
antagonists
c-akt
drug
effects
erbB-2
erbB-3
genetics
identify
inhibitors
of
protein
response
therapeutic
therapy
use
&AntibodiesBiologicalCarcinomaDosageDrugEpidermalFactorGeneGrowthHumanHumansImmunohistochemistryInhibitorsKinaseKinasesLungMarkersMonoclonalMutationNeoplasmNeoplasmsNon-Small-CellPhosphoproteinsPredictiveProteinProtein-TyrosineProteinsProto-OncogeneQuinazolinesReceptorResistanceTestsTyrosineValueanalysisantagonistsc-aktdrugeffectserbB-2erbB-3geneticsidentifyinhibitorsofproteinresponsetherapeutictherapyuse
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1Severe cardiomyopathy in a patient with renal cell carcinoma after treatment with the novel tyrosine kinase inhibitor sunitinib
E. Chorianopoulos, D. Jager, H. Katus, and N. Frey. Clin.Res.Cardiol., 96 (11): 829-830 (2007)
15 years ago by @kanefendt
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Aged
Agents
Angiogenesis
Antineoplastic
Carcinoma
Cardiomyopathies
Cell
Dysfunction
Echocardiography
Female
Humans
Illness
Index
Indoles
Inhibitors
Kidney
Kinase
Kinases
Left
Neoplasms
Protein-Tyrosine
Pyrroles
Renal
Severity
Tyrosine
Ventricular
adverse
antagonists
chemically
contraindications
drug
effects
induced
inhibitors
of
therapy
&AgedAgentsAngiogenesisAntineoplasticCarcinomaCardiomyopathiesCellDysfunctionEchocardiographyFemaleHumansIllnessIndexIndolesInhibitorsKidneyKinaseKinasesLeftNeoplasmsProtein-TyrosinePyrrolesRenalSeverityTyrosineVentricularadverseantagonistschemicallycontraindicationsdrugeffectsinducedinhibitorsoftherapy
(0)
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1Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition
T. Force, D. Krause, and R. van Etten. Nat.Rev.Cancer, 7 (5): 332-344 (2007)
15 years ago by @kanefendt
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Adaptor
Antibodies
Benzenesulfonates
Biological
Delivery
Diseases
Drug
Enzyme
Heart
Human
Humans
Indoles
Inhibitors
Kinase
Kinases
Models
Monoclonal
Mutation
Neoplasms
Protein
Protein-Tyrosine
Proteins
Proto-Oncogene
Pyridines
Pyrroles
Quinazolines
Research
Signal
Systems
Transducing
Tyrosine
adverse
antagonists
c-abl
cells
chemically
development
drug
effects
growth
induced
inhibitors
physiology
protein
response
therapy
toxicity
&AdaptorAntibodiesBenzenesulfonatesBiologicalDeliveryDiseasesDrugEnzymeHeartHumanHumansIndolesInhibitorsKinaseKinasesModelsMonoclonalMutationNeoplasmsProteinProtein-TyrosineProteinsProto-OncogenePyridinesPyrrolesQuinazolinesResearchSignalSystemsTransducingTyrosineadverseantagonistsc-ablcellschemicallydevelopmentdrugeffectsgrowthinducedinhibitorsphysiologyproteinresponsetherapytoxicity
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1Molecular basis for sunitinib efficacy and future clinical development
S. Faivre, G. Demetri, W. Sargent, and E. Raymond. Nat.Rev.Drug Discov., 6 (9): 734-745 (2007)
15 years ago by @kanefendt
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A
Angiogenesis
Animals
Carcinoma
Clinical
Design
Drug
Endothelial
Factor
France
Growth
Humans
Indoles
Inhibitors
Kinase
Kinases
Neoplasm
Neoplasms
Protein-Tyrosine
Pyrroles
Receptors
Resistance
Topic
Trials
Tyrosine
Vascular
adverse
antagonists
as
biosynthesis
blood
drug
effects
enzymology
inhibitors
metabolism
pharmacology
response
supply
therapeutic
therapy
use
&AAngiogenesisAnimalsCarcinomaClinicalDesignDrugEndothelialFactorFranceGrowthHumansIndolesInhibitorsKinaseKinasesNeoplasmNeoplasmsProtein-TyrosinePyrrolesReceptorsResistanceTopicTrialsTyrosineVascularadverseantagonistsasbiosynthesisblooddrugeffectsenzymologyinhibitorsmetabolismpharmacologyresponsesupplytherapeutictherapyuse
(0)
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1The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a review
F. Eskens, and J. Verweij. Eur.J.Cancer, 42 (18): 3127-3139 (2006)
15 years ago by @kanefendt
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A
Angiogenesis
Antibodies
Endothelial
Factor
Growth
Humans
Inhibitors
Kinase
Kinases
Medical
Monoclonal
Neoplasms
Neovascularization
Oncology
Pathologic
Protein
Protein-Tyrosine
Receptors
Tyrosine
Vascular
adverse
antagonists
blood
control
drug
effects
inhibitors
prevention
protein
supply
therapy
toxicity
&AAngiogenesisAntibodiesEndothelialFactorGrowthHumansInhibitorsKinaseKinasesMedicalMonoclonalNeoplasmsNeovascularizationOncologyPathologicProteinProtein-TyrosineReceptorsTyrosineVascularadverseantagonistsbloodcontroldrugeffectsinhibitorspreventionproteinsupplytherapytoxicity
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1Vascular endothelial growth factor expression in monocytes from patients with primary antiphospholipid syndrome
M. Cuadrado, P. Buendia, F. Velasco, M. Aguirre, N. Barbarroja, L. Torres, M. Khamashta, and C. Lopez-Pedrera. J.Thromb.Haemost., 4 (11): 2461-2469 (2006)
15 years ago by @kanefendt
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A
Adolescent
Adult
Aged
Antibodies
Antiphospholipid
Cells
Cultured
Endothelial
Enzyme
Expression
Factor
Female
Gene
Growth
Human
Humans
Imidazoles
Inhibitors
Kinase
Kinases
MAP
Male
Middle
Mitogen-Activated
Monocytes
Phenotype
Protein
Pyridines
Receptor-1
Regulation
Research
Signaling
Syndrome
System
Thromboplastin
Thrombosis
Tyrosine
Vascular
antagonists
biosynthesis
cells
drug
effects
inhibitors
metabolism
p38
pathology
pharmacology
protein
&AAdolescentAdultAgedAntibodiesAntiphospholipidCellsCulturedEndothelialEnzymeExpressionFactorFemaleGeneGrowthHumanHumansImidazolesInhibitorsKinaseKinasesMAPMaleMiddleMitogen-ActivatedMonocytesPhenotypeProteinPyridinesReceptor-1RegulationResearchSignalingSyndromeSystemThromboplastinThrombosisTyrosineVascularantagonistsbiosynthesiscellsdrugeffectsinhibitorsmetabolismp38pathologypharmacologyprotein
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1Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
H. Burstein, A. Elias, H. Rugo, M. Cobleigh, A. Wolff, P. Eisenberg, M. Lehman, B. Adams, C. Bello, S. Deprimo and 2 other author(s). J Clin Oncol, 26 (11): 1810-1816 (2008)
15 years ago by @kanefendt
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&
Administration
Adult
Aged
Agents
Anthracyclines
Antineoplastic
Biological
Breast
Bridged
Carcinoma
Chemotherapy
Combined
Compounds
Diseases
Drug
Fatigue
Female
Gastrointestinal
Growth
Hematologic
Humans
Indoles
Inflammation
Kinase
Kinases
Markers
Middle
Neoplasms
Oral
Plasma
Protein-Tyrosine
Protocols
Pyrroles
Rate
Schedule
Survival
Taxoids
Tumor
Tyrosine
administration
adverse
analysis
antagonists
blood
chemically
classification
dosage
drug
effects
induced
inhibitors
methods
mortality
response
secondary
therapeutic
therapy
use
&AdministrationAdultAgedAgentsAnthracyclinesAntineoplasticBiologicalBreastBridgedCarcinomaChemotherapyCombinedCompoundsDiseasesDrugFatigueFemaleGastrointestinalGrowthHematologicHumansIndolesInflammationKinaseKinasesMarkersMiddleNeoplasmsOralPlasmaProtein-TyrosineProtocolsPyrrolesRateScheduleSurvivalTaxoidsTumorTyrosineadministrationadverseanalysisantagonistsbloodchemicallyclassificationdosagedrugeffectsinducedinhibitorsmethodsmortalityresponsesecondarytherapeutictherapyuse
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1Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-Kit, in patients with advanced or metastatic solid tumors
F. Eskens, N. Steeghs, J. Verweij, J. Bloem, O. Christensen, D. van, J. Ouwerkerk, M. Jonge, J. Nortier, J. Kraetzschmar and 2 other author(s). J.Clin.Oncol., 27 (25): 4169-4176 (2009)
15 years ago by @kanefendt
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A
Administration
Adolescent
Adult
Aged
Angiogenesis
Biological
Contrast
Dose
Dose-Response
Drug
Endothelial
Factor
Factors
Fatigue
Female
Growth
Human
Humans
Hypertension
Imaging
Inhibitors
Kinase
Magnetic
Male
Markers
Maximum
Media
Medical
Metastasis
Middle
Neoplasm
Neoplasms
Oncology
Oral
Outcome
Pharmacokinetics
Plasma
Platelet-Derived
Protein
Proteins
Proto-Oncogene
Pyridazines
Pyridines
Receptor
Receptor-2
Receptor-3
Relationship
Research
Resonance
Safety
Schedule
Time
Tolerated
Treatment
Tumor
Tyrosine
Vascular
Young
administration
adverse
antagonists
beta
blood
c-kit
diagnostic
dosage
drug
effects
enzymology
inhibitors
methods
pathology
protein
response
supply
therapy
toxicity
use
&AAdministrationAdolescentAdultAgedAngiogenesisBiologicalContrastDoseDose-ResponseDrugEndothelialFactorFactorsFatigueFemaleGrowthHumanHumansHypertensionImagingInhibitorsKinaseMagneticMaleMarkersMaximumMediaMedicalMetastasisMiddleNeoplasmNeoplasmsOncologyOralOutcomePharmacokineticsPlasmaPlatelet-DerivedProteinProteinsProto-OncogenePyridazinesPyridinesReceptorReceptor-2Receptor-3RelationshipResearchResonanceSafetyScheduleTimeToleratedTreatmentTumorTyrosineVascularYoungadministrationadverseantagonistsbetabloodc-kitdiagnosticdosagedrugeffectsenzymologyinhibitorsmethodspathologyproteinresponsesupplytherapytoxicityuse
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1Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors
R. Kumar, M. Crouthamel, D. Rominger, R. Gontarek, P. Tummino, R. Levin, and A. King. Br.J.Cancer, 101 (10): 1717-1723 (2009)
15 years ago by @kanefendt
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3
50
Angiogenesis
Benzenesulfonates
Bone
Cell
Cells
Concentration
Diseases
Endothelial
Factor
Growth
Hematologic
Hematopoietic
Human
Humans
Indoles
Inhibitors
Inhibitory
Kinase
Line
Marrow
Myelopoiesis
Phosphorylation
Platelet-Derived
Protein
Proteins
Proto-Oncogene
Pyridines
Pyrimidines
Pyrroles
Receptors
Research
Specificity
Stem
Substrate
Sulfonamides
Tumor
Tyrosine
Vascular
antagonists
c-kit
chemically
drug
effects
enzymology
fms-Like
induced
inhibitors
methods
pharmacology
protein
&350AngiogenesisBenzenesulfonatesBoneCellCellsConcentrationDiseasesEndothelialFactorGrowthHematologicHematopoieticHumanHumansIndolesInhibitorsInhibitoryKinaseLineMarrowMyelopoiesisPhosphorylationPlatelet-DerivedProteinProteinsProto-OncogenePyridinesPyrimidinesPyrrolesReceptorsResearchSpecificityStemSubstrateSulfonamidesTumorTyrosineVascularantagonistsc-kitchemicallydrugeffectsenzymologyfms-Likeinducedinhibitorsmethodspharmacologyprotein
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1Vascular endothelial growth factor governs endothelial nitric-oxide synthase expression via a KDR/Flk-1 receptor and a protein kinase C signaling pathway
B. Shen, D. Lee, and T. Zioncheck. J.Biol.Chem., 274 (46): 33057-33063 (1999)
15 years ago by @kanefendt
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A
Adrenal
Animals
Aorta
C
Cattle
Cell
Cells
Cortex
Cultured
Endothelial
Endothelium
Enzyme
Enzymologic
Ester
Expression
Factor
Factors
Gene
Growth
II
Inhibitors
Kinase
Kinases
Line
Lymphokines
Methyl
NG-Nitroarginine
Nitric
Oxide
Penicillamine
Pharmacokinetics
Protein
Protein-Tyrosine
Proteins
Receptor
Receptors
Recombinant
Regulation
Signal
Substances
Synthase
Transduction
Type
Tyrosine
Up-Regulation
Vascular
analogs
cells
derivatives
drug
effects
metabolism
pharmacology
protein
&AAdrenalAnimalsAortaCCattleCellCellsCortexCulturedEndothelialEndotheliumEnzymeEnzymologicEsterExpressionFactorFactorsGeneGrowthIIInhibitorsKinaseKinasesLineLymphokinesMethylNG-NitroarginineNitricOxidePenicillaminePharmacokineticsProteinProtein-TyrosineProteinsReceptorReceptorsRecombinantRegulationSignalSubstancesSynthaseTransductionTypeTyrosineUp-RegulationVascularanalogscellsderivativesdrugeffectsmetabolismpharmacologyprotein
(0)
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1Differential binding characteristics and cellular inhibition by soluble VEGF receptors 1 and 2
W. Roeckl, D. Hecht, H. Sztajer, J. Waltenberger, A. Yayon, and H. Weich. Exp.Cell Res., 241 (1): 161-170 (1998)
15 years ago by @kanefendt
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A
Agents
Animals
BALB
Binding
C
Cell
Cells
Cloning
Competitive
Cross-Linking
Dimerization
Endothelial
Expression
Factor
Factors
Fibrinolytic
Gene
Growth
Heparin
Human
Humans
Inbred
Kinase
Kinases
Ligands
Lymphokines
Mice
Mitogens
Molecular
Plastics
Proliferation
Protein
Protein-Tyrosine
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1VEGF receptor signaling in tumor angiogenesis
G. McMahon. Oncologist., (2000)
15 years ago by @kanefendt
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1Possible participation of autocrine and paracrine vascular endothelial growth factors in hypoxia-induced proliferation of endothelial cells and pericytes
M. Nomura, S. Yamagishi, S. Harada, Y. Hayashi, T. Yamashima, J. Yamashita, and H. Yamamoto. J.Biol.Chem., 270 (47): 28316-28324 (1995)
15 years ago by @kanefendt
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1Soluble Tie2 and Flt1 extracellular domains in serum of patients with renal cancer and response to antiangiogenic therapy
A. Harris, P. Reusch, B. Barleon, C. Hang, N. Dobbs, and D. Marme. Clin.Cancer Res., 7 (7): 1992-1997 (2001)
15 years ago by @kanefendt
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2The galanin receptor type 2 initiates multiple signaling pathways in small cell lung cancer cells by coupling to G(q), G(i) and G(12) proteins

1Interactions between intracellular cyclic AMP and agonist-induced inositol phospholipid breakdown in isolated gastric mucosal cells of the rat

2Regulation of phosducin-like protein by casein kinase 2 and N-terminal splicing

1Regulation of p42/p44 mitogen-activated protein kinase by the human adenosine A3 receptor in transfected CHO cells

2Surrogate predictive biomarkers for response to anti-EGFR agents: state of the art and challenges

1Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib

2Surrogate predictive biomarkers for response to anti-EGFR agents: state of the art and challenges

1Severe cardiomyopathy in a patient with renal cell carcinoma after treatment with the novel tyrosine kinase inhibitor sunitinib

1Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition

1Molecular basis for sunitinib efficacy and future clinical development

1The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a review

1Vascular endothelial growth factor expression in monocytes from patients with primary antiphospholipid syndrome

1Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane

1Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-Kit, in patients with advanced or metastatic solid tumors

1Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors

1Vascular endothelial growth factor governs endothelial nitric-oxide synthase expression via a KDR/Flk-1 receptor and a protein kinase C signaling pathway

1Differential binding characteristics and cellular inhibition by soluble VEGF receptors 1 and 2

1VEGF receptor signaling in tumor angiogenesis

1Possible participation of autocrine and paracrine vascular endothelial growth factors in hypoxia-induced proliferation of endothelial cells and pericytes

1Soluble Tie2 and Flt1 extracellular domains in serum of patients with renal cancer and response to antiangiogenic therapy

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