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A single protein in the brain influences arousal of despair, according to new study in mice. Brain biopsies revealed that mice trying hardest to escape shocks had highest levels of delta-FosB - which may also help humans avoid hopelessness & helplessness.
B. Song, M. Marschollek, K. Wolf, M. Gietzelt, T. Franken, and R. Haux. MEDINFO 2010 - Proceedings of the 13th World Congress on Medical
Informatics, volume 160 of Stud Health Technol Inform, page 48--52. Amsterdam, IOS Press, (2010)