This protocol provides detailed instructions on Quality Control, EWAS, and CpG island signature discovery with Illumina Infinitum MethylationEPIC and Infinium Human Methylation 450K BeadChip data. R package minfi and caret was used in this analysis.
M. Feuer, L. Towne, and R. Shavelson. Educational Researcher, 31 (8):
4(2002)“For example, when well-specified causal hypotheses can be formulated and randomization to treatment and control conditions is ethical and feasible, a randomized experiment is the best method for estimating effects” p. 8.