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Since 2010, biological disease-modifying antirheumatic drugs (bDMARDs) have been the dominant mode of treatment for rheumatoid arthritis (RA). However, the safety of DMARDs, such as tumor necrosis factor inhibitors (TNFis) and Janus kinase inhibitors (JAKis), in treating patients with RA is a concern. We compared the safety outcomes of JAKis and TNFis in RA patients in clinical settings. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Secukinumab, the first IL-17A inhibitor, is widely used to treat immune diseases, including plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis. Here, we aimed to explore the clinical characteristics, outcomes, and time to onset of the four main toxicities of secukinumab, using post-marketing data. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Aim: To summarise the effectiveness of organisational interventions on appropriate opioid prescribing for non-cancer pain upon hospital discharge. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Poor adherence to allopurinol among people with gout contributes to suboptimal gout management. This study sought to understand the facilitators and barriers to allopurinol adherence across the three stages of medication adherence, and patient perspectives on strategies to improve adherence. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This article highlights practical considerations in the initiation, switching and discontinuation of biologics in the management of JIA. To read the full article, log in using your NHS OpenAthens details.
Experimental and Clinical Psychopharmacology (May 23, 2019). DOI:10.1037/pha0000281
Chronic pain states have resulted in an overreliance on opioid pain relievers, which can carry significant risks when used long term. As such, alternative pain treatments are increasingly desired. Although emerging research suggests that cannabinoids have therapeutic potential regarding pain, results from studies across pain populations have been inconsistent. To provide meta-analytic clarification regarding cannabis’s impact on subjective pain, we identified studies that assessed drug-induced pain modulations under cannabinoid and corresponding placebo conditions. To read the full article, log in using your NHS OpenAthens details.
Palindromic rheumatism (PR) is characterized by self-resolving and short duration attacks of arthritis/periarthritis. The present study was performed to report the results of PR treatment with methotrexate (MTX). To read the full article, log in using your NHS OpenAthens details.
This study evaluates predictors for successful biologic tapering among patients with inflammatory arthritis (IA) using baseline characteristics from the BIODOPT trial. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
We've added 10 new Be Aware updates following your suggestions:
Musculoskeletal ; Osteoporosis ; Nutrition and obesity ; Falls ; HR ; Research Methods ; Information Governance ; Bladder, bowel and pelvic healthcare ; Rheumatology ; Medicines and healthcare products regulatory agency (circulated email)
Old age and glucocorticoid (GC) use increase the susceptibility to infection in patients with rheumatoid arthritis (RA). Accordingly, we investigated whether GC discontinuation reduces the incidence of infection in older adults with RA and analyzed factors associated with GC discontinuation. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease, which is characterized by massive pain and destruction of synovial joints, leads to bone erosion, damage to cartilage, and disability. Several studies suggested that resveratrol supplementation may be effective in the prevention and management of RA. To read the full article, choose “Institutional Login” and search for “Midlands Partnership”.
This issue of the Journal is primarily focused on new advances in the diagnosis and treatment of opioid use disorder. The issue begins with an overview by Drs. Cecilia Bergeria and Eric Strain from Johns Hopkins University (1) that discusses the prevalence of opiate use disorder and associated lethal overdoses as well as current pharmacologic and nonpharmacologic treatment approaches. Elsewhere in the issue, making the diagnosis of prescription-related opiate use disorder (POUD) can be challenging and in this regard a paper explores the impacts of modifying current criteria for POUD on prevalence rates. Another paper assesses the efficacy of buprenorphine/naloxone, primarily taken at home, for treating POUD. Also related to treatment, another paper characterizes the effects of COVID-19 telehealth policy changes related to buprenorphine treatment on VA patients with opiate use disorder. We also present papers in this issue that address the prevalence of cannabis use disorder in the VA population and the possibility of using a mindfulness-based intervention as a nonpharmacologic treatment for pain. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This editorial looks at therapeutic drugs for gout. Although various therapies are available for gout treatment, the target of healing gout is often not achieved. Gout treatment often requires long-term medication, drug safety requires special attention. Open access article - no login required.
The goal of treatment in palindromic rheumatism (PR) is to control the attacks and prevent disease evolution to chronic arthritis. Conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) including antimalarial and methotrexate cannot control attacks in all patients. The goal of treatment in palindromic rheumatism (PR) is to control the attacks and prevent disease evolution to chronic arthritis. Conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) including antimalarial and methotrexate cannot control attacks in all patients. To read the full article, choose “Institutional Login” and search for “Midlands Partnership”.
This retrospective cohort study aimed to evaluate the effect of the interaction between methotrexate and glucocorticoids on the risk of developing bacterial infections in patients with rheumatoid arthritis (RA) using biological disease-modifying antirheumatic drugs (bDMARDs). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The aim of this study was to assess the correlation between adherence assessed with a Medication Event Monitoring System (MEMS) versus pill count, MTX-polyglutamate (PG) concentration and Compliance-Questionnaire-Rheumatology (CQR) in patients with established rheumatoid arthritis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
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