In the Injury Theory, it's damage to the arterial endothelium, followed by platelet activation, then smooth muscle cell migration to injury, then macrophages, with resulting "foam cells." Engorged foam cells burst, starting the injury cycle all over again
Curcuma longa, a powerhouse plant, is highly antiinflammatory, treating cardiovascular, metabolic, and rheumatic disorders. Turmeric oils (a leaf fraction) and curcuminoids make this "curry" ingredient an essential culinary/medicinal botanical.
Statins have pleiotropic effects: anti-inflammatory, immunomodulatory, antithrombotic, and vascular activity, & may improve left ventricular myocardial function & left ventricular diastolic function by increasing vascular elasticity.
For "traditional" cardiologists, CAD is a blockage or blockages in the coronary arteries, and the treatment is stents. For "nontraditional" cardiologists, CAD is a more systemic, diffuse condition, and the treatment is systemic.
A decrease in the oxidative damage to low-density lipoprotein (LDL) cholesterol is one of the protective mechanisms in which a traditional Mediterranean diet exerts a protective effect on coronary heart disease development.
it may no longer be enough to measure just HDL levels without determining levels of paroxonase and platelet-activating acetylhydrolase; levels of these enzymes may determine whether HDL is proinflammatory or protective. Likewise, measuring Lp(a) and small
Elevated levels of myeloperoxidase in otherwise healthy men and women increased the likelihood of overt coronary artery disease by 50% over 8 years compared with patients who had the lowest levels of the enzyme (P<0.001), according to a 2007 report publis
Inflammation: (Latin, inflammatio, to set on fire) is the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants.
Human resolvin E1 inhibits both the migration of inflammatory cells to sites of inflammation and the turning on of other inflammatory cells. Aspirin-triggered resolivins are made from omega-3 fatty acids by cellular enzymes. COX-2 inhibitors also inhibit
After adjusting for other risk factors impaired fasting glucose was associated with a 2.5-fold increase in the risk of a fatal cardiac event within five years (hazard ratio 2.5, 95% CI 1.2-5.1), said Elizabeth L.M. Barr, M.P.H., of the International Diabe
Third Joint Task Force of European and other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of eight societies and by invited experts).
Two Swiss meta-analyses have found an increased rate of myocardial infarction and death with the Cypher (sirolimus-eluting) coronary stent, which is likely to put a serious chill in interventional cardiology's infatuation with drug-coated devices
Statins may act on an enzyme called endothelial nitric oxide synthase, which stimulates nitric oxide production. Increased nitric oxide has anti-inflammatory and anti-clotting effects...
The roles and functions of cytokines are confusing and still being sorted out. Over three dozen have been identified with more being discovered each day.
Millions of Americans are deficient in the vital digestive enzyme called D6D (delta-6 desaturase) required to convert flax oil into EPA and GLA, the two nutrients that fight inflammation. Unlike flax seed oil, borage and fish oils do not require that prob
Overweight men and women assigned to drink fructose-sweetened beverages as 25% of their energy intake developed atherogenic lipid profiles in just two weeks; unlike glucose, fructose promotedatherogenic lioproprotein phenotypes and glucose intolerance/ins