Erythropoietin (EPO) improves verbal memory and reverses subfield hippocampal volume loss across depression and bipolar disorder (BD). This study aimed to investigate with functional magnetic resonance imaging (fMRI) whether these effects were accompanied by functional changes in memory-relevant neuro-circuits in this cohort. Login using your SSSFT NHS OpenAthens details for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you requesting.
There have been inconsistent findings from randomised controlled trials (RCTs) and systematic reviews on the efficacies of selective serotonin reuptake inhibitors (SSRIs) as the first-line treatment of major depressive disorder (MDD). Besides inconsistencies among randomised controlled trials (RCTs), their risks of bias and evidence grading have seldom been evaluated in meta-analysis. This study aims to compare the efficacy of SSRIs by conducting a Bayesian network meta-analysis, which will be the most comprehensive evaluation of evidence to resolve the inconsistency among previous studies. To read the full article, log in using your NHS OpenAthens details
There is increasing evidence that some glutamatergic drugs could have antidepressant effects. Ketamine as a promising prototype for novel glutamatergic antidepressants has a much faster onset of action and is possibly more efficacious than standard antidepressants.1 Two recent systematic reviews and meta-analyses assessed the antidepressant efficacy (including modes of administration, duration of effect and adverse effects) of ketamine and other glutamate receptor modulators in the treatment of unipolar depression (Caddy et al,2 in the Cochrane Database of Systematic Reviews), and, more generally, in mood disorders (Newport et al,3 in the American Journal of Psychiatry). To read the full article, log in using your NHS OpenAthens details
News article: Scientists at King's College London have developed a blood test that accurately and reliably predicts whether depressed patients will respond to common antidepressants, which could herald a new era of personalised treatment for people with depression.
depression is common in people with poor physical health, particularly within the acute medical in-patient setting. Co-morbid depression contributes to poor outcomes, and screening for depression in acute medical in-patients has been advocated. The Edinburgh Depression Scale (EDS) has been validated in a variety of general hospital patient groups, but not previously in older acute medical in-patients. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Perinatal suicide is a rare but tragic complication of pregnancy and childbirth with significant public health implications.1 Among women with psychiatric illness, prior research suggests that suicide risk may be increased as much as 70-fold if compared with the general population.2 Beyond this, little is known about risk factors for completed suicide among perinatal women and there is a lack of population-based research on this topic. To read the full article, log in using your NHS OpenAthens details
The exponential proliferation of social media sites has caused wide scale social changes over the last decade or so. The combined result of Web 2.0 coding, smart phone availability and rapid widely available mobile data networks means that we can now all participate in online social communication whenever and wherever we are.
Undoubtedly this has its advantages (or so we think, given that one in seven humans has a Facebook account) in terms of keeping in touch, self-publicising our achievements (or photos of our breakfasts) and networking with others. It also however comes with a darker side; perhaps soaking up time from more meaningful face-to-face interactions, exposing us to cyber-bullying or forcing upon us an endless stream of the selective, sanitized and overstated highlights of our “friends’” lives. (Cf Wait But Why’s excellent blog about Why Generation Y yuppies are so unhappy).
Several studies have been set up trying to answer the question of net benefit versus net cost to our mental health of these new media platforms, and so far mixed results have emerged. Adding perhaps a little more weight to this debate is the recent publication of a large survey in Depression and Anxiety by Liu yi Lin and colleagues from Pittsburgh, entitled: Association between Social Media Use and Depression Among U.S. Young Adults (Lin, 2016).
Adolescence is a period of increased risk for the development of depression. Epidemiological and clinical studies suggest that the phenomenology of depression may differ during childhood and adolescence. However, participants in these studies may not reflect depressed young people referred to routine clinical services. The aim of this paper was to describe referrals for depression to a UK routine public healthcare service for children and adolescents with mental health difficulties. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Previous neuroimaging studies indicate abnormalities in cortico-limbic circuitry in mood disorder. Here we employ prospective longitudinal voxel-based morphometry to examine the trajectory of these abnormalities during early stages of illness development. You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
The overall lifetime prevalence of seasonal affective disorder (SAD) ranges as high as 9.7%.1 Light therapy, where bright artificial light is used to replace diminished sunlight, can be an effective non-drug treatment for SAD.2 However, alternative non-drug treatment approaches are also needed. Cognitive behavioural therapy (CBT) is an established and effective treatment for depressive disorders.3 Limited research examining CBT adapted specifically for SAD (CBT-SAD) is available. To read the full article, log in using your NHS OpenAthens details
There is increasing evidence that some glutamatergic drugs could have antidepressant effects. Ketamine as a promising prototype for novel glutamatergic antidepressants has a much faster onset of action and is possibly more efficacious than standard antidepressants.1 Two recent systematic reviews and meta-analyses assessed the antidepressant efficacy (including modes of administration, duration of effect and adverse effects) of ketamine and other glutamate receptor modulators in the treatment of unipolar depression (Caddy et al,2 in the Cochrane Database of Systematic Reviews), and, more generally, in mood disorders (Newport et al,3 in the American Journal of Psychiatry). To read the full article, log in using your NHS OpenAthens details
Scientists have discovered 15 genome sites – the first ever – linked to depression in people of European ancestry. Many of these regions of depression-linked genetic variation turn out to be involved in regulating gene expression and the birth of new neurons in the developing brain.
We investigated effects of attentional bias modification training on anxiety and depression.
Two types of training were compared to placebo control conditions.
Unselected adolescents received eight sessions of online training.
Visual search, but not dot-probe training reduced negative attentional bias.
Long-term emotional functioning improved irrespective of condition. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
ABSTRACT FROM: Andersson NW, Gustafsson LN, Okkels N, et al. Depression and the risk of autoimmune disease: a nationally representative, prospective longitudinal study. Psychol Med 2015;45:3559–69. To read the full article, log in using your NHS OpenAthens details.
ABSTRACT FROM: Weitz ES, Hollon SD, Twisk J, et al. Baseline depression severity as moderator of depression outcomes between cognitive behavioral therapy vs pharmacotherapy: an individual patient data meta-analysis. JAMA Psychiatry 2015;72:1102–9. To read the full article, log in using your NHS OpenAthens details.
Deficits in reinforcement-based decision making have been reported in generalized anxiety disorder. However, the pathophysiology of these deficits is largely unknown; published studies have mainly examined adolescents, and the integrity of core functional processes underpinning decision making remains undetermined. In particular, it is unclear whether the representation of reinforcement prediction error (PE) (the difference between received and expected reinforcement) is disrupted in generalized anxiety disorder. This study addresses these issues in adults with the disorder. : Login at top right hand side of page using your SSSFT NHS Athens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
The evidence for what helps people experiencing severe and long-term depression is thin, with current NICE guidelines on the recognition and management of depression in adults making the case for new research to improve the treatment and care of this group.
This new paper by Richard Morriss and colleagues, reported in The Lancet Psychiatry, is one response to this call.