Newer-generation antidepressants used in monotherapy or in combination with other newer-generation antidepressants or other psychotropic drugs are usually preferred as first- or second-step treatment options in resistant depression. According to our clinical experience, tricyclic antidepressants still are one of our preferred first choices in treatment-resistant moderate to severe unipolar major depressive episodes.. MPFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
People should look out for signs of depression and dementia among older family members and friends over Christmas, NHS England expert Professor Alistair Burns urged today.
Problems that may have been hidden can come to the surface or be easier to spot as families or friends get together over the festive season, Prof Burns said.
Depression should not be written off as inevitable in old age and can be treated effectively. Emotional changes can also be the first indication that someone has dementia.
Open access. Bipolar and other psychiatric disorders are associated with considerably increased risk of suicidal behaviour, which may include self-poisoning with medication used to treat the disorder. Therefore, choice of medication for treatment should include consideration of toxicity, especially for patients at risk. The aim of this study was to estimate the relative toxicity of specific drugs within two drug categories, antipsychotics and mood stabilizers, using large-scale databases to provide evidence that could assist clinicians in making decisions about prescribing, especially for patients at risk of suicidal behaviour.
Psychiatric Rehabilitation Journal (Dec 20, 2018). DOI:10.1037/prj0000331
Objective: Self-management support is recognized as an important component of the management of mood and anxiety disorders. The goal of this feasibility study was to evaluate the acceptability, implementation and perceived usefulness of a new comprehensive self-management tool ( Getting better my way) in four care settings in Quebec, Canada. To read the full article, log in using your NHS OpenAthens details.
Psychodermatology is the interaction between skin and mind. Psychodermatological conditions are present in many patients with a mental health condition or mental health concerns. However, conditions such as dermatitis artefacta and trichotillomania are commonly misunderstood, and access to treatment may be limited. Nurses play a vital role in supporting patients and families by assessing, treating and managing such conditions, while also providing education on the condition and the treatment that is required. This article describes common psychodermatological conditions and the variety of care that can be carried out. To read the full article, log in using your MPFT NHS OpenAthens details.
Psychological Medicine; Cambridge Vol. 49, Iss. 3, (Feb 2019): 449. DOI:10.1017/S0033291718001058
The aim of this study was to explore the relationship between patient self-reported Patient Health Questionnaire-9 (PHQ-9) symptoms and doctor diagnosis of depression using a tree analysis approach.. To read the full article, log in using your NHS OpenAthens details.
Psychological Medicine; Cambridge Vol. 49, Iss. 3, (Feb 2019): 491. DOI:10.1017/S0033291718001113
Insomnia and depression are highly comorbid and mutually exacerbate clinical trajectories and outcomes. Cognitive behavioral therapy for insomnia (CBT-I) effectively reduces both insomnia and depression severity, and can be delivered digitally. This could substantially increase the accessibility to CBT-I, which could reduce the health disparities related to insomnia; however, the efficacy of digital CBT-I (dCBT-I) across a range of demographic groups has not yet been adequately examined. This randomized placebo-controlled trial examined the efficacy of dCBT-I in reducing both insomnia and depression across a wide range of demographic groups.. To read the full article, log in using your NHS OpenAthens details.
Open access. Anxiety and depressive disorders are common mental disorders. A substantial part of patients does not achieve symptomatic remission after treatment in specialized services. Current care as usual (CAU) for these patients consists of long-term supportive contacts. Termination of CAU is often not considered to be an option due to persistent symptoms, a low level of functioning, and the absence of further treatment options. A new intervention, ZemCAD, offers a program focused on rehabilitation and self-management, followed by referral back to primary care.
Neuroticism is a heritable personality trait, characterized by negative emotions such as worrying, feelings of guilt, loneliness and being easily hurt. Increased levels of neuroticism are associated with poor mental health – development of depression in particular – but it remains uncertain whether this association represents a causal effect [1]. Here, we use Mendelian randomization (MR) to investigate whether neuroticism is a causal risk factor for development of depression.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
We evaluated birth cohort differences in depressive symptom burden, prevalence of depression diagnoses, and neuroticism, among Swedish 70‐year‐olds examined between 1976 and 2016. . To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Studies involving clinically recruited samples show that genetic liability to schizophrenia overlaps with that for several psychiatric disorders including bipolar disorder, major depression and, in a population study, anxiety disorder and negative symptoms in adolescence.. To read the full article, log in using your MPFT NHS OpenAthens details.
To synthesize recent knowledge on the association of urbanization (and neighbourhood factors) and anxiety and stress-related disorders. . Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Open access. Several studies have suggested that depression is associated with an increased risk for fracture; however, the results are conflicting. This study aimed to conduct a meta-analysis of cohort studies assessing the association between depression and the risk for fracture.
Pioneering research over the past two decades has shown that memories are far more malleable than we once thought, thereby highlighting the potential for new clinical avenues for treatment of psychopathology. We first briefly review the historical foundation of memory reconsolidation—a concept that refers to hypothetical processes that occur when a memory is retrieved and restored. Then, we provide an overview of the basic research on memory reconsolidation that has been done with humans and other animals, focusing on models of fear, anxiety-related disorders, and addiction, from the perspective that they all involve disorders of memory. This basic research has fuelled early stage developments of novel treatment techniques.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Electroconvulsive therapy (ECT) is an effective treatment for severe depressive disorders, with older age being predictive of a better outcome. Two earlier small studies have suggested an increased prevalence of dementia in patients having received ECT, but were flawed by major methodological shortcomings. Recent data on both short-term and long-term impact of ECT on cognitive function in older patients are reassuring,1 even in the presence of age-related brain changes.2. To read the full article, log in using your NHS OpenAthens details.
It has taken more than 40 years for Lisa Rodrigues to talk about her mental health difficulties. She hopes her candour will help others who are struggling at the top. A year before she left her position as the chief executive of a mental health trust, Lisa Rodrigues wrote about her depression and anxiety, which began when she was 15 years old. ‘I’d been secretive about it,’ says Ms Rodrigues, who qualified as a nurse in 1977 at Great Ormond Street Hospital in London. ‘But I thought I’d kept it secret for long enough. It’s about destigmatising.’ To read the full article, log in using your MPFT NHS OpenAthens details.
Ketamine has been documented for its rapid antidepressant effects. However, optimal dose and delivery route have not yet been thoroughly investigated. The objectives of this study were to document the safety and test the antidepressant and antisuicidal effects of a single rapid 1-minute injection of ketamine 0.5 mg/kg in treatment-resistant depression (TRD). . MPFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Canadian Psychology/Psychologie canadienne Vol. 59, Iss. 4, (Nov 2018): 301-314. DOI:10.1037/cap0000155
Face-to-face cognitive-behavioral therapy (CBT) and interpersonal therapy (IPT) are time-limited, structured psychotherapies recommended for the management of adult major depressive disorder (MDD) and generalized anxiety disorder (GAD). We conducted a systematic review to evaluate the reporting and methodological quality, and cost-effectiveness of economic evaluations that examined these two thoroughly researched psychotherapies.. To read the full article, log in using your MPFT NHS OpenAthens details.