Open access. Lithium is an established treatment for bipolar disorder and an augmenting agent for treatment-resistant depression. Despite awareness of renal adverse effects, including chronic kidney disease, for the past five decades, there has been a lack of research evidence. This has led to debates around the existence and magnitude of the risk. This article discusses the current evidence base regarding the link between lithium and chronic kidney disease, monitoring of renal functions and its clinical implications.
We launched the Medicines Learning Portal website www.medicineslearningportal.org in 2016 to teach junior hospital pharmacists in the NHS how to solve clinical problems about medicines.
This free-to-view site was developed with support from Health Education England and many others.
By July 2017 it had received over 250,000 visits and the site is endorsed by the professional body for pharmacists, the Royal Pharmaceutical Society.
This study evaluated rates of all-cause mortality and self-harm in association with clozapine treatment in individuals with treatment-resistant schizophrenia. Login at top right hand side of page using your SSSFT NHS Athens for full text.
In their presentation of guidelines for the use of ketamine in mood disorders, Sanacora et al1 rightly state that ketamine is not standard treatment in psychiatry but then inexplicably refer to 0.5 mg/kg intravenously over 40 minutes as the “standard” dose. How can there be a standard dose for a nonstandard treatment? Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Patient nonadherence to psychopharmacological treatment is a significant barrier to effective treatment. The therapeutic relationship is known to be a critical component of effective psychological treatment, but it has received limited study. A meta-analysis was conducted to examine the role of the therapeutic relationship in the delivery of effective psychopharmacological treatment. Login at top right hand side of page using your SSSFT NHS OpenAthens for full text.
Suzanne Dash on a meta-analysis of CBT and antidepressants for depression that looked at negative & positive responses and what predicted different outcomes
An estimated 50% of patients do not take their medication as prescribed, with medication adherence associated with adverse outcomes and higher costs of care. The Necessity-Concerns Framework identified individual’s beliefs about their medication as playing a key role in adherence, and UK Clinical Adherence Guidelines recommend eliciting and incorporating individual’s perceptions of their medication within the consultation. The Beliefs about Medicines Questionnaire (BMQ) is widely used to assess medication beliefs, however, given the condition-specific nature of some self-management regimens, it is unknown whether this tool is able to fully capture beliefs about more complex medication regimens.
Treatment of schizophrenia and major depressive disorder (MDD) with atypical antipsychotics (AAPs) show improved efficacy and reduced side effect burden compared with older antipsychotic medications. However, a risk of treatment-emergent adverse events (TEAEs) remains. TEAEs are hard to quantify and perspectives on the importance of TEAEs differ across patients and between patients and physicians. The current study is a qualitative assessment that investigates TEAEs of AAPs from both patient and physician perspectives to provide better understanding of the occurrence and burden of TEAEs associated with these medications.
This document summarises the evidence-base on low-dose antipsychotics in people with dementia. It is a key therapeutic topic which has been identified to support medicines optimisation. It is not formal NICE guidance.
Black Hairy Tongue Associated With Lorazepam Treatment of a Male Smoker With Major Depression. SSSFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
SSSFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Intranasal Ketamine and Cognitive-Behavioral Therapy for Treatment-Refractory Obsessive-Compulsive Disorder. SSSFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Treatment Duration With Long-Acting Injectable Antipsychotics After In-hospital Initiation: A Retrospective Cohort Study. SSSFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Atypical Antipsychotics and the Risk of Falls and Fractures Among Older Adults: An Emulation Analysis and an Evaluation of Additional Confounding Control Strategies. SSSFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
The influence of baseline severity has been examined for antidepressant medications but has not been studied properly for cognitive–behavioural therapy (CBT) in comparison with pill placebo. You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
It includes our role with controlled drug intelligence networks (CD LINs), the National Group on Controlled Drugs and the Cross-Border Group for safer management of controlled drugs.
The report sets out key changes to legislation and gives an overview of prescribing data and prescribing trends for controlled drugs across England in the primary care sector. It also makes recommendations to strengthen existing arrangements.
Letter. SSSFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Letter. SSSFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Letter. SSSFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.