Schizophrenia is a severe psychiatric disorder of complex etiology. Immune processes have long been proposed to contribute to the development of schizophrenia, and accumulating evidence supports immune involvement in at least a subset of cases. In recent years, large-scale genetic studies have provided new insights into the role of the immune system in this disease. Here, we provide an overview of the immunogenetic architecture of schizophrenia based on findings from genome-wide association studies (GWAS).. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Free. Acute psychotic illness, especially when associated with agitated or violent behavior, can require urgent pharmacological tranquillization or sedation. In many countries, benzodiazepines (either alone or in combination with antipsychotics) are often used in this situation (1).
From web-based applications to mobile devices, digital technologies hold tremendous potential to facilitate the delivery of healthcare for mental disorders, including schizophrenia. These eHealth (ie, electronic health) tools are increasingly being used to assist consumers during the course of their illnesses, from the provision of the continuity of care to improving well-being.1 This makes sense due to the growing trends of digital tool usage in psychiatric samples. . Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Contrary to the notion that neurology but not psychiatry is the domain of disorders evincing structural brain alterations, it is now clear that there are subtle but consistent neuropathological changes in schizophrenia. These range from increases in ventricular size to dystrophic changes in dendritic spines. A decrease in dendritic spine density in the prefrontal cortex (PFC) is among the most replicated of postmortem structural findings in schizophrenia. Examination of the mechanisms that account for the loss of dendritic spines has in large part focused on genes and molecules that regulate neuronal structure. But the simple question of what is the effector of spine loss, ie, where do the lost spines go, is unanswered.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
The onset of schizophrenia occurs during a period critical for development of social relationships and functional independence. As such, interventions that target the early course of illness have the potential to stave off functional decline and restore functioning to pre-illness levels. In this entirely remote study, people with recent-onset schizophrenia spectrum disorders (SSDs) participated in a 12-week randomized controlled trial to determine the efficacy of PRIME (personalized real-time intervention for motivational enhancement), a mobile-based digital health intervention designed to improve motivation and quality of life.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai