Three new 3-hydroxy-N-methyl-2-oxindole (1 and 2) and
4-hydroxy-pyran-2-one (3) derivatives, along with the known
3-hydroxy-N-methyl-2-oxindole (4) and 6-methoxy-N-methylisatin (5) were
isolated from a marine Salinispora arenicola strain from sediments of
the St. Peter and St. Paul Archipelago, Brazil. The structures of the
new compounds were elucidated by a combination of spectroscopic (1D and
2D NMR and HR-ESIMS) data, including single-crystal X-ray diffraction
analysis for 2 and 3. Compounds 1 to 5 were assayed for their
antimicrobial properties, but only 4 and 5 were active against
Enterococcus faecalis with MIC value of 15.6 mu g/mL.
%0 Journal Article
%1 WOS:000498290700033
%A Silva, Alison B
%A Pinto, Francisco C L
%A Silveira, Edilberto R
%A V, Leticia Costa-Lotufo
%A Costa, Wendell S
%A Ayala, Alejandro Pedro
%A Canuto, Kirley M
%A Barros, Ayslan B
%A Araujo, Ana Jersia
%A Filho, Jose Delano B Marinho
%A Pessoa, Otilia Deusdenia L
%C RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
%D 2019
%I ELSEVIER
%J FITOTERAPIA
%K 3-Hydroxy-N-methyl-2-oxindole; 4-Hydroxy-pyran-2-one; Antimicrobial Marine X-ray actinomycete; activity} analysis; arenicola; structure {Salinispora
%R 10.1016/j.fitote.2019.104357
%T 4-Hydroxy-pyran-2-one and 3-hydroxy-N-methyl-2-oxindole derivatives of
Salinispora arenicola from Brazilian marine sediments
%V 138
%X Three new 3-hydroxy-N-methyl-2-oxindole (1 and 2) and
4-hydroxy-pyran-2-one (3) derivatives, along with the known
3-hydroxy-N-methyl-2-oxindole (4) and 6-methoxy-N-methylisatin (5) were
isolated from a marine Salinispora arenicola strain from sediments of
the St. Peter and St. Paul Archipelago, Brazil. The structures of the
new compounds were elucidated by a combination of spectroscopic (1D and
2D NMR and HR-ESIMS) data, including single-crystal X-ray diffraction
analysis for 2 and 3. Compounds 1 to 5 were assayed for their
antimicrobial properties, but only 4 and 5 were active against
Enterococcus faecalis with MIC value of 15.6 mu g/mL.
@article{WOS:000498290700033,
abstract = {Three new 3-hydroxy-N-methyl-2-oxindole (1 and 2) and
4-hydroxy-pyran-2-one (3) derivatives, along with the known
3-hydroxy-N-methyl-2-oxindole (4) and 6-methoxy-N-methylisatin (5) were
isolated from a marine Salinispora arenicola strain from sediments of
the St. Peter and St. Paul Archipelago, Brazil. The structures of the
new compounds were elucidated by a combination of spectroscopic (1D and
2D NMR and HR-ESIMS) data, including single-crystal X-ray diffraction
analysis for 2 and 3. Compounds 1 to 5 were assayed for their
antimicrobial properties, but only 4 and 5 were active against
Enterococcus faecalis with MIC value of 15.6 mu g/mL.},
added-at = {2022-05-23T20:00:14.000+0200},
address = {RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS},
author = {Silva, Alison B and Pinto, Francisco C L and Silveira, Edilberto R and V, Leticia Costa-Lotufo and Costa, Wendell S and Ayala, Alejandro Pedro and Canuto, Kirley M and Barros, Ayslan B and Araujo, Ana Jersia and Filho, Jose Delano B Marinho and Pessoa, Otilia Deusdenia L},
biburl = {https://www.bibsonomy.org/bibtex/2af5c73f0fd2ed630313618e198c2749f/ppgfis_ufc_br},
doi = {10.1016/j.fitote.2019.104357},
interhash = {3da57efbd52e7dea16ecb2e1ddc6f0b9},
intrahash = {af5c73f0fd2ed630313618e198c2749f},
issn = {0367-326X},
journal = {FITOTERAPIA},
keywords = {3-Hydroxy-N-methyl-2-oxindole; 4-Hydroxy-pyran-2-one; Antimicrobial Marine X-ray actinomycete; activity} analysis; arenicola; structure {Salinispora},
publisher = {ELSEVIER},
pubstate = {published},
timestamp = {2022-05-23T20:00:14.000+0200},
title = {4-Hydroxy-pyran-2-one and 3-hydroxy-N-methyl-2-oxindole derivatives of
Salinispora arenicola from Brazilian marine sediments},
tppubtype = {article},
volume = 138,
year = 2019
}