%0 Journal Article %1 White.2002 %A White, J. D. %A Hewett, P. W. %A Kosuge, D. %A McCulloch, T. %A Enholm, B. C. %A Carmichael, J. %A Murray, J. C. %D 2002 %J Cancer Res. %K Adenoma Aged Analysis Biological Carcinoma Colorectal Conditions D Endothelial Factor Factors Female Growth Humans Immunohistochemistry Intestinal Kinase Kinases Laboratories Lymphatic Male Markers Mucosa Multivariate Neoplasms Neovascularization Pathologic Precancerous Prognosis Protein-Tyrosine Receptor Receptor-3 Receptors Research Tumor Vascular Vessels analysis biosynthesis blood metabolism pathology supply %N 6 %P 1669-1675 %T Vascular endothelial growth factor-D expression is an independent prognostic marker for survival in colorectal carcinoma %U PM:11912138 %V 62 %X The angiogenic factor vascular endothelial growth factor-D (VEGF-D) isa ligand for VEGF receptor-3 (VEGFR-3/Flt-4) and receptor-2 (VEGFR-2/KDR)and is implicated in the development of lymphatic vessels and promotion of lymphatic metastases. We assessed the expression of VEGF-D and VEGFR-3 in relation to microvessel density (MVD) in colorectal carcinomas (CRC), adenomas, and adjacent normal tissue by immunohistochemistry on consecutive archival sections. VEGF-D was detected in malignant and benign epithelium and in some smooth muscle of the colorectum. High-grade VEGF-D expression was observed frequently (74%) in CRC compared with adenomas (0%) and adjacent normal mucosa (22%). High-grade VEGF-D expression was not correlated with MVD, Dukes' stage (A to C), or tumor differentiation, but was associated with lymphatic involvement and patient survival. By multivariate analysis, VEGF-D expression was found to be an independent prognostic factor for both disease-free and overall survival. VEG

@article{White.2002, abstract = {The angiogenic factor vascular endothelial growth factor-D (VEGF-D) isa ligand for VEGF receptor-3 (VEGFR-3/Flt-4) and receptor-2 (VEGFR-2/KDR)and is implicated in the development of lymphatic vessels and promotion of lymphatic metastases. We assessed the expression of VEGF-D and VEGFR-3 in relation to microvessel density (MVD) in colorectal carcinomas (CRC), adenomas, and adjacent normal tissue by immunohistochemistry on consecutive archival sections. VEGF-D was detected in malignant and benign epithelium and in some smooth muscle of the colorectum. High-grade VEGF-D expression was observed frequently (74%) in CRC compared with adenomas (0%) and adjacent normal mucosa (22%). High-grade VEGF-D expression was not correlated with MVD, Dukes' stage (A to C), or tumor differentiation, but was associated with lymphatic involvement and patient survival. By multivariate analysis, VEGF-D expression was found to be an independent prognostic factor for both disease-free and overall survival. VEG}, added-at = {2010-02-05T11:28:39.000+0100}, author = {White, J. D. and Hewett, P. W. and Kosuge, D. and McCulloch, T. and Enholm, B. C. and Carmichael, J. and Murray, J. C.}, biburl = {https://www.bibsonomy.org/bibtex/2cffa35b919a1654dcce56c8e6994bb7a/kanefendt}, interhash = {7e9e6fd65591fc88a7c7f7b15972c569}, intrahash = {cffa35b919a1654dcce56c8e6994bb7a}, journal = {Cancer Res.}, keywords = {Adenoma Aged Analysis Biological Carcinoma Colorectal Conditions D Endothelial Factor Factors Female Growth Humans Immunohistochemistry Intestinal Kinase Kinases Laboratories Lymphatic Male Markers Mucosa Multivariate Neoplasms Neovascularization Pathologic Precancerous Prognosis Protein-Tyrosine Receptor Receptor-3 Receptors Research Tumor Vascular Vessels analysis biosynthesis blood metabolism pathology supply}, number = 6, pages = {1669-1675}, timestamp = {2010-02-05T11:28:41.000+0100}, title = {Vascular endothelial growth factor-D expression is an independent prognostic marker for survival in colorectal carcinoma}, url = {PM:11912138}, volume = 62, year = 2002 }