By focusing on well-known examples, Goodall, through his compelling writing style, points to easily identifiable signposts that trapped “great” men. The profiles in Why Great Men Fall give pause to others in similar environments: corporate execs, mini
A single protein in the brain influences arousal of despair, according to new study in mice. Brain biopsies revealed that mice trying hardest to escape shocks had highest levels of delta-FosB - which may also help humans avoid hopelessness & helplessness.
Modafinil induces wakefulness, but its dopamine-releasing action in the nucleus accumbens is weak and dose-dependent; no likelihood of euphoric response ('abuse potential').
Weak willpower & procrastination caused by dopamine hypofunction is one of those neurological deficiencies which effort alone can't overcome. Happily, in our transhuman paradise, even the most lethargic spirit can move mountains.
Authorities report that more than half the population experiences trauma, which makes people more likely to develop PTSD, depression, anxiety and physical illness later in life. Now, a new study finds that among ‘healthy’ individuals, those who displa
The social avoidance that normally develops when a mouse repeatedly experiences defeat by a dominant animal disappears when it lacks a gene for a memory molecule in a brain circuit for social learning, scientists funded by the National Institutes of Healt
Pioneering research over the past two decades has shown that memories are far more malleable than we once thought, thereby highlighting the potential for new clinical avenues for treatment of psychopathology. We first briefly review the historical foundation of memory reconsolidation—a concept that refers to hypothetical processes that occur when a memory is retrieved and restored. Then, we provide an overview of the basic research on memory reconsolidation that has been done with humans and other animals, focusing on models of fear, anxiety-related disorders, and addiction, from the perspective that they all involve disorders of memory. This basic research has fuelled early stage developments of novel treatment techniques.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Electroconvulsive therapy (ECT) is an effective treatment for severe depressive disorders, with older age being predictive of a better outcome. Two earlier small studies have suggested an increased prevalence of dementia in patients having received ECT, but were flawed by major methodological shortcomings. Recent data on both short-term and long-term impact of ECT on cognitive function in older patients are reassuring,1 even in the presence of age-related brain changes.2. To read the full article, log in using your NHS OpenAthens details.
Ketamine has been documented for its rapid antidepressant effects. However, optimal dose and delivery route have not yet been thoroughly investigated. The objectives of this study were to document the safety and test the antidepressant and antisuicidal effects of a single rapid 1-minute injection of ketamine 0.5 mg/kg in treatment-resistant depression (TRD). . MPFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
It has taken more than 40 years for Lisa Rodrigues to talk about her mental health difficulties. She hopes her candour will help others who are struggling at the top. A year before she left her position as the chief executive of a mental health trust, Lisa Rodrigues wrote about her depression and anxiety, which began when she was 15 years old. ‘I’d been secretive about it,’ says Ms Rodrigues, who qualified as a nurse in 1977 at Great Ormond Street Hospital in London. ‘But I thought I’d kept it secret for long enough. It’s about destigmatising.’ To read the full article, log in using your MPFT NHS OpenAthens details.