In much of the world (but not in the U.S.,) drug-coated stents are avoided by cardiologists because of their high cost. To compensate for the inability to use these stents, many cardiologists outside of the U.S. have taken to administering sirolimus (also
Electron Beam CT, or EBCT scans (formerly called ultrafast CT scans) are useful in detecting the presence of calcium deposits in the lining of the coronary arteries. The presence of calcium deposits is a strong indicator that coronary artery disease is al
Overweight men and women assigned to drink fructose-sweetened beverages as 25% of their energy intake developed atherogenic lipid profiles in just two weeks; unlike glucose, fructose promotedatherogenic lioproprotein phenotypes and glucose intolerance/ins
"Inflammation is a very effective mechanism for fighting off invaders," says Peter Libby, M.D., chief of cardiovascular medicine at Brigham and Women's Hospital in Boston. "But when the body is exposed to invaders for long periods of time, the defense mec
Chronic inflammation is also involved in diseases as diverse as atherosclerosis, cancer, heart valve dysfunction, obesity, diabetes, congestive heart failure, digestive system diseases, and Alzheimer's disease...The New England Journal of Medicine publish
Over the past several years, medicine has started to recognise the fundamental role of inflammation in nearly every disease process. Researchers and physicians have been redefining heart disease, Alzheimer’s, and even diabetes and obesity as inflammator
TFA intake is positively associated with markers of systemic inflammation in women. Further investigation of the influences of TFAs on inflammation and of implications for coronary disease, diabetes, and other conditions is warranted.
Two Swiss meta-analyses have found an increased rate of myocardial infarction and death with the Cypher (sirolimus-eluting) coronary stent, which is likely to put a serious chill in interventional cardiology's infatuation with drug-coated devices
Third Joint Task Force of European and other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of eight societies and by invited experts).
After adjusting for other risk factors impaired fasting glucose was associated with a 2.5-fold increase in the risk of a fatal cardiac event within five years (hazard ratio 2.5, 95% CI 1.2-5.1), said Elizabeth L.M. Barr, M.P.H., of the International Diabe
Elevated levels of myeloperoxidase in otherwise healthy men and women increased the likelihood of overt coronary artery disease by 50% over 8 years compared with patients who had the lowest levels of the enzyme (P<0.001), according to a 2007 report publis
it may no longer be enough to measure just HDL levels without determining levels of paroxonase and platelet-activating acetylhydrolase; levels of these enzymes may determine whether HDL is proinflammatory or protective. Likewise, measuring Lp(a) and small
From commodity ingredients such as vitamins C and E and dietary fibre to proprietary ones like LitoZin rose hip extract or Celadrin, the arsenal of natural products to address the many conditions with inflammation at their core will continue to expand. Co
For "traditional" cardiologists, CAD is a blockage or blockages in the coronary arteries, and the treatment is stents. For "nontraditional" cardiologists, CAD is a more systemic, diffuse condition, and the treatment is systemic.
Pro-inflammatory eicosanoids and cytokines are produced from arachidonic acid, and omega-3s have been shown to inhibit arachidonic acid metabolism, hence less pro-inflammatory synthesis. Understand how to use fish oils to prevent chronic disease.
Statins have pleiotropic effects: anti-inflammatory, immunomodulatory, antithrombotic, and vascular activity, & may improve left ventricular myocardial function & left ventricular diastolic function by increasing vascular elasticity.
JPEN: Journal of Parenteral and Enteral Nutrition: Synergistic Anti-Inflammatory Activity of [omega]-3 Lipid and Rofecoxib Pretreatment on Macrophage Proinflammatory Cytokine Production Occurs via Divergent NF-[kappa]B Activation/Discussant/Author's Reply
In the Injury Theory, it's damage to the arterial endothelium, followed by platelet activation, then smooth muscle cell migration to injury, then macrophages, with resulting "foam cells." Engorged foam cells burst, starting the injury cycle all over again