%0 Journal Article %1 mclean_emergence_2004 %A McLean, Catherine A %A Wang, Susan A %A Hoff, Gerald L %A Dennis, Lesha Y %A Trees, David L %A Knapp, Joan S %A Markowitz, Lauri E %A Levine, William C %D 2004 %J Sexually Transmitted Diseases %K Adolescent, Adult, Aged, Agents, Azithromycin, Bacterial, Communicable Diseases, Drug Emerging, Factors, Female, Gonorrhea, Humans, Male, Microbial Middle Missouri, Neisseria Resistance, Risk Sensitivity Studies, Tests, gonorrhoeae, {Anti-Bacterial} {Case-Control} {Risk-Taking} %N 2 %P 73--78 %R 10.1097/01.OLQ.0000109514.91508.FC %T The emergence of Neisseria gonorrhoeae with decreased susceptibility to Azithromycin in Kansas City, Missouri, 1999 to 2000 %U http://www.ncbi.nlm.nih.gov/pubmed/14743069 %V 31 %X BACKGROUND AND OBJECTIVES: We describe the first cluster of persons with Neisseria gonorrhoeae with decreased susceptibility to azithromycin (AziDS; minimum inhibitory concentration \textgreater/=1.0 microg/mL) in the United States.GOAL The goal of this study was to identify risk factors for AziDS N. gonorrhoeae and to describe isolate microbiology. STUDY DESIGN: Persons with AziDS N. gonorrhoeae (cases) were identified in Kansas City, Missouri, through the Gonococcal Isolate Surveillance Project (GISP) in 1999 and expanded surveillance, January 2000 to June 2001. A case-control study using 1999 GISP participants was conducted; control subjects had azithromycin-susceptible N. gonorrhoeae. RESULTS: Thirty-three persons with AziDS N. gonorrhoeae were identified. Case patients were older than control patients (median age, 33 years vs. 23 years; P \textless0.001). Fifty percent of cases and 13\% of control subjects had a history of sex with a female commercial sex worker (odds ratio, 7.0; 95\% confidence interval, 1.3-36.0); 50\% of cases and 4\% of control subjects met sex partners on street A (P \textless0.01). AziDS N. gonorrhoeae isolates were phenotypically and genotypically similar and contained an mtrR gene mutation. CONCLUSIONS: With few treatment options remaining, surveillance for antimicrobial-resistant N. gonorrhoeae is increasingly important, especially among persons at high risk.

@article{mclean_emergence_2004, abstract = {{BACKGROUND} {AND} {OBJECTIVES:} We describe the first cluster of persons with Neisseria gonorrhoeae with decreased susceptibility to azithromycin {(AziDS;} minimum inhibitory concentration {\textgreater}/=1.0 {microg/mL)} in the United {States.GOAL} The goal of this study was to identify risk factors for {AziDS} N. gonorrhoeae and to describe isolate microbiology. {STUDY} {DESIGN:} Persons with {AziDS} N. gonorrhoeae (cases) were identified in Kansas City, Missouri, through the Gonococcal Isolate Surveillance Project {(GISP)} in 1999 and expanded surveillance, January 2000 to June 2001. A case-control study using 1999 {GISP} participants was conducted; control subjects had azithromycin-susceptible N. gonorrhoeae. {RESULTS:} Thirty-three persons with {AziDS} N. gonorrhoeae were identified. Case patients were older than control patients (median age, 33 years vs. 23 years; P {\textless}0.001). Fifty percent of cases and 13\% of control subjects had a history of sex with a female commercial sex worker (odds ratio, 7.0; 95\% confidence interval, 1.3-36.0); 50\% of cases and 4\% of control subjects met sex partners on street A {(P} {\textless}0.01). {AziDS} N. gonorrhoeae isolates were phenotypically and genotypically similar and contained an {mtrR} gene mutation. {CONCLUSIONS:} With few treatment options remaining, surveillance for antimicrobial-resistant N. gonorrhoeae is increasingly important, especially among persons at high risk.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {{McLean}, Catherine A and Wang, Susan A and Hoff, Gerald L and Dennis, Lesha Y and Trees, David L and Knapp, Joan S and Markowitz, Lauri E and Levine, William C}, biburl = {https://www.bibsonomy.org/bibtex/20d4d0e7fadb0b830d5ad9364fe790ce3/jelias}, doi = {10.1097/01.OLQ.0000109514.91508.FC}, interhash = {c738409118d77260b45779b351c009d9}, intrahash = {0d4d0e7fadb0b830d5ad9364fe790ce3}, issn = {0148-5717}, journal = {Sexually Transmitted Diseases}, keywords = {Adolescent, Adult, Aged, Agents, Azithromycin, Bacterial, Communicable Diseases, Drug Emerging, Factors, Female, Gonorrhea, Humans, Male, Microbial Middle Missouri, Neisseria Resistance, Risk Sensitivity Studies, Tests, gonorrhoeae, {Anti-Bacterial} {Case-Control} {Risk-Taking}}, month = feb, note = {{PMID:} 14743069}, number = 2, pages = {73--78}, timestamp = {2011-03-11T10:06:14.000+0100}, title = {The emergence of Neisseria gonorrhoeae with decreased susceptibility to Azithromycin in Kansas City, Missouri, 1999 to 2000}, url = {http://www.ncbi.nlm.nih.gov/pubmed/14743069}, volume = 31, year = 2004 }