The RAP project enables developers to build rich, Ajax-enabled Web applications by using the Eclipse development model, plug-ins with the well known Eclipse workbench extenstion points, JFace, and a widget toolkit with SWT API.
The AJAX Libraries API is a content distribution network and loading architecture for the most popular open source JavaScript libraries. By using the Google AJAX API Loader's google.load() method, your application has high speed, globaly available access
PyFacebook is currently best-tested with Django, and if you are just starting out with Python web development, the author highly recommends this combination :-). If you'd rather use another framework, there are also Pylons and other WSGI helpers in PyFacebook as well.