In the Injury Theory, it's damage to the arterial endothelium, followed by platelet activation, then smooth muscle cell migration to injury, then macrophages, with resulting "foam cells." Engorged foam cells burst, starting the injury cycle all over again
it may no longer be enough to measure just HDL levels without determining levels of paroxonase and platelet-activating acetylhydrolase; levels of these enzymes may determine whether HDL is proinflammatory or protective. Likewise, measuring Lp(a) and small
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Y. Baumer, V. Spindler, R. Werthmann, M. Bunemann, and J. Waschke. J Cell Physiol, 220 (3):
716-26(September 2009)Baumer, Y Spindler, V Werthmann, R C Bunemann, M Waschke, J Research
Support, Non-U.S. Gov't United States Journal of cellular physiology
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