Nordic walking (NW) may be a beneficial treatment for people with Parkinson's disease (PD). The purpose of this study was to conduct a systematic review and meta-analysis on the effectiveness of NW as a rehabilitation strategy for PD. To read the full article, choose “Institutional Login” and search for “Midlands Partnership”
Active lifelong cognitive lifestyles increase cognitive reserve and have beneficial effects on global cognition, cognitive decline and dementia risk in Parkinson's disease (PD). Executive function is particularly impaired even in early PD, and this impacts on quality of life. The effects of lifelong cognitive lifestyle on executive function in PD have not been studied previously. This study examined the association between lifelong cognitive lifestyle, as a proxy measure of cognitive reserve, and executive function in people with PD. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
A pioneering team that developed an app allowing people with epilepsy to monitor their own condition and health risk, has been shortlisted for a prestigious British Medical Journal (BMJ) Award in the Innovation Team category. The BMJ Award is one of the highest honours available within the medical and healthcare professions.
Mild cognitive impairment (MCI) is common in early Parkinson's disease (PD). We evaluated the stability of PD-MCI over time to determine its clinical utility as a marker of disease. To read the full article, log in using your NHS OpenAthens details.
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Editorial commentary. In their JNNP paper, Gooneratna et al1 review long-term studies of three surgical therapies for pharmacoresistant focal epilepsy: vagal nerve stimulation, which provides the most evidence, anterior thalamic nucleus deep brain stimulation (ANT DBS) and cortical responsive stimulation (CRS). Written for the generalist, the review describes the three technologies in detail. The multiple layers of information gathered inform the generalist of how complex treatment decisions can be. As medical intractability can be predicted early, typically after failure of a second drug or the presence of abnormal imaging, this serves as a reminder that such patients should be considered for early referral to a specialist multidisciplinary …To read the full article, log in using your NHS OpenAthens details.
Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical course and outcome. Intravenous immunoglobulin (IVIg) and plasma exchange are proven effective treatments, but the efficacy has been demonstrated mainly on motor improvement in adults with a typical and severe form of GBS. In clinical practice, treatment dilemmas may occur in patients with a relatively mild presentation, variant forms of GBS, or when the onset of weakness was more than 2 weeks ago. Other therapeutic dilemmas may arise in patients who do not improve or even progress after initial treatment. We provide an overview of the current literature about therapeutic options in these situations, and additionally give our personal view that may serve as a basis for therapeutic decision-making. To read the full article, log in using your NHS OpenAthens details.
Zumba Gold® is a dance-based workout developed for older adults that could be beneficial for mobility and well-being in people Parkinson’s (PD). However, to date there is no evidence to support the suitability of this type of exercise in people with PD. To read the full article, log in using your NHS OpenAthens details
Complementary non-pharmacological approaches, such as aerobic exercise, have been evaluated for over two decades. The heterogeneity of the interventions and outcomes used hinders the interpretation of the effect of exercise in PD.1 Several systematic reviews and meta-analyses have pooled the results, but their conclusions depend greatly on the diversity of the included exercise modalities. .....To read the full article, log in using your NHS OpenAthens details.
Objective: To determine feasibility of a randomised controlled trial (RCT) of home-based Reach-to- Grasp training after stroke.
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Objective: To explore the factors perceived to affect rehabilitation assessment and referral practices for patients with stroke. To read the full article, log in using your SSSFT NHS OpenAthens details
Behavioural changes associated with epilepsy can be challenging for patients and clinicians. Evidence suggests an association between aggression and epilepsy that involves various neurophysiological and neurochemical disturbances. Anti-epileptics have variable effects on behaviour and cognition that need consideration. Early detection and careful consideration of history, symptomatology and possible common comorbid psychiatric disorders is essential. Appropriate investigations should be considered to aid diagnosis, including electroencephalogram (EEG), video EEG telemetry and brain imaging. Optimising treatment of epilepsy, treatment of psychiatric comorbidities and behavioural management can have a major positive effect on patients’ recovery and well-being. To read the full article, log in using your NHS OpenAthens details.
Neuropsychiatric signs and symptoms occur frequently in individuals with multiple sclerosis (MS), either as the initial presenting complaint prior to a definitive neurological diagnosis or more commonly with disease progression. However, the pathogenesis of these comorbid conditions remains unclear and it remains difficult to accurately elucidate if neuropsychiatric symptoms or conditions are indicators of MS illness severity. Furthermore, both the disease process and the treatments of MS can adversely impact an individual’s mental health. In this review, we discuss the common neuropsychiatric syndromes that occur in MS and describe the clinical symptoms, aetiology, neuroimaging findings and management strategies for these conditions. To read the full article, log in using your NHS OpenAthens details.
This study examines the association of time of onset of autonomic dysfunction with disease progression and survival in Parkinson disease. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
This population-based cohort study examines the outcomes of epilepsy and use of antiepileptic drugs during pregnancy in women and infants. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Neuropsychiatric symptoms are common in Parkinson's disease (PD) and have a disproportionate impact on quality of life and carer burden. Pharmacological treatment is the main approach in dealing with these symptoms, but it is limited by variable efficacy and risk of drug interactions. Non-pharmacological approaches using the cognitive–behavioural therapy (CBT) model are viable alternatives and in this review paper we summarise the evidence of CBT for three of the most common psychiatric manifestations of PD: depression and anxiety, impulse-control disorders and insomnia. To read the full article, log in using your NHS OpenAthens details.
There are few reports on the tolerability and efficacy of perampanel, a new antiepileptic drug with a novel mechanism of action, in children and adolescents. We aimed to describe our experience with perampanel add-on and mono-therapy in children with refractory epilepsy. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Case conference. Login at top right hand side of page using your SSSFT NHS Athens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Neuroendocrine abnormalities are common in Parkinson's disease (PD) and include disruption of melatonin secretion, disturbances of glucose, insulin resistance and bone metabolism, and body weight changes. They have been associated with multiple non-motor symptoms in PD and have important clinical consequences, including therapeutics. Some of the underlying mechanisms have been implicated in the pathogenesis of PD and represent promising targets for the development of disease biomarkers and neuroprotective therapies. In this systems-based review, we describe clinically relevant neuroendocrine abnormalities in Parkinson's disease to highlight their role in overall phenotype. We discuss pathophysiological mechanisms, clinical implications, and pharmacological and non-pharmacological interventions based on the current evidence. We also review recent advances in the field, focusing on the potential targets for development of neuroprotective drugs in Parkinson's disease and suggest future areas for research. To read the full article, log in using your NHS OpenAthens details.
Neuropsychology31.6 (Sep 2017): 585-595.
Objective: Emotional and cognitive disturbances are common complications in Parkinson’s disease (PD). N400 is an event related potential (ERP) strongly linked to lexical-semantic processing and has demonstrated alterations in amplitude and latency when PD patients performed semantic priming tasks. The present study investigated the role of N400 in an automatic affective priming paradigm in PD. Other ERP components relevant to emotion processing were also examined. To read the full article, log in using your NHS OpenAthens details.
Surgical treatment can bring seizure remission in people with focal epilepsy but requires careful selection of candidates.
Objectives To determine which preoperative factors are associated with postoperative seizure outcome. To read the full article, log in using your NHS OpenAthens details.
Open access. Conclusion: Except for epilepsy, this research has indicated that the risks of drowning while undertaking aquatic activities are not increased in children with pre-existing medical conditions. Children with pre-existing medical conditions can enjoy aquatic activities when appropriately supervised.
While the increased risk of ALS was statistically significant, the overall risk of ALS was still tiny in the exposure group. Of the 58,279 men in the study only 88 died of ALS. With figures as low as these, there is always the risk than any identified link is actually down to chance.
The diagnosis of delirium depends on eliciting its features through mental status examination and informant history. However, there is marked heterogeneity in how these features are assessed, from binary subjective clinical judgement to more comprehensive methods supported by cognitive testing. The aim of this article is to review the neuropsychological research in delirium and suggest future directions in research and clinical practice. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
An observational study identified living people with epilepsy who matched (by age and geographical region) adolescents and adults with a postmortem diagnosis of sudden unexpected death in epilepsy (SUDEP). Use of an intervention to prevent SUDEP was determined for each participant who died (before entry into the study or subsequently). Fewer people died when an intervention to reduce SUDEP was employed (on average, 213 fewer deaths per 1000 people with nocturnal supervision and 184 fewer deaths per 1000 people with special precautions). However, data were available for only 367 of the 616 live participants recruited, and evidence was of very low quality, making firm conclusions impossible.
Blog post. Back in the 1960s, Nobel-prize winning research shook our understanding of what it means to be a conscious entity. Epilepsy patients who’d had the thick bundle of nerves connecting their two brain hemispheres either severed or removed (as a drastic treatment for their epilepsy) responded in laboratory tasks as if they had two separate minds.
It’s an unsettling idea that has appeared in psychology textbooks for decades. But dig into the original studies and you’ll find the evidence for split brains leading to split minds was mostly descriptive. Now a team of researchers led by Yair Pinto at the University of Amsterdam has conducted systematic testing of two split-brain patients over several years, specifically to find out whether the division of their brains has also separated their consciousness. In fact, the results, published recently in the journal Brain, suggest their consciousness remains unified. It may be time to rewrite the textbooks.
Editorial. Wahid et al1 describe a boy with cerebral palsy, epilepsy and severe learning difficulties who developed major gastrointestinal problems leading to an extended period of parenteral nutrition (PN) as an inpatient. ....... An important aspect of this case is that after a very long and difficult illness (and against all expectations), gastrointestinal function improved to the extent that weaning from PN was possible. To read the full article, log in using your NHS OpenAthens details.
The aim of this meta-analysis was to evaluate and synthesise the available evidence from the previous 20 years regarding the utility of psychological interventions in the management of psychogenic non-epileptic seizures (PNES). To read the full article, log in using your NHS OpenAthens details.
Question Is uncomplicated childhood-onset epilepsy associated with increased brain amyloid accumulation?
Findings In this population-based case-control study of Finnish adults who had childhood epilepsy and were followed up prospectively for more than 50 years from their disease onset and a group of matched controls, individuals with childhood-onset epilepsy, and particularly APOE ε4 carriers, had an increased brain amyloid load as measured with positron emission tomography at late middle age.
Meaning Childhood-onset epilepsy is linked with a biomarker that might be associated with accelerated brain aging and can be considered as a neurobiological predisposition to later-life cognitive disorders. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Research News. A cannabis based drug has shown encouraging results in treating a form of epilepsy unresponsive to existing drugs.
Children with Dravet syndrome, a rare and catastrophic form of epilepsy, may experience many seizures a day. The condition, caused in most cases by a known genetic mutation affecting sodium channels in the brain, occurs in one child in 40 000 and leads to developmental damage and long term learning difficulties. Children affected require lifelong care.
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Open access. To examine the baseline prevalence and longitudinal evolution in non-motor symptoms (NMS) in a prospective cohort of, at baseline, patients with de novo Parkinson’s disease (PD) compared with healthy controls (HC).
Blood-brain barrier (BBB) disruption has long been recognised as an important early feature of multiple sclerosis (MS) pathology. Traditionally, this has been seen as a by-product of the myelin-specific immune response. Here, we consider whether vascular changes instead play a central role in disease pathogenesis, rather than representing a secondary effect of neuroinflammation or neurodegeneration. To read the full article, log in using your NHS OpenAthens details.
Among patients with inflammatory bowel disease, what is the incidence of Parkinson disease, and does earlier exposure to anti–tumor necrosis factor therapy mitigate their risk of Parkinson disease?. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
What is the risk and medication contribution to cause-specific unnatural mortality in people with epilepsy?. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Surveys of patients with multiple sclerosis report that most are interested in modifying their diet and using supplements to potentially reduce the severity and symptoms of the disease. This review provides an updated overview of the current state of evidence for the role that vitamins and dietary supplements play in multiple sclerosis and its animal models, with an emphasis on recent studies, and addresses biological plausibility and safety issues.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Small prospective studies have identified that children exposed to valproate in utero have poorer scores on cognitive testing. We wanted to identify whether children exposed to antiepileptic drugs (AEDs) in utero have poorer school performance.. To read the full article, log in using your NHS OpenAthens details.
Open access. Review evidence for cannabinoids as adjunctive treatments for treatment-resistant epilepsy. Systematic search of Medline, Embase and PsycINFO was conducted in October 2017. Outcomes were: 50%+ seizure reduction, complete seizure freedom; improved quality of life (QoL). Tolerability/safety were assessed by study withdrawals, adverse events (AEs) and serious adverse events (SAEs).
To develop an instrument (Paediatric Rehabilitation Ingredients Measure [PRISM]) for quantitative estimation of contents of interdisciplinary neurorehabilitation for use in studies of relationships between rehabilitation treatment delivered and severity-adjusted outcomes after acquired brain injury (ABI).. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
To examine the appropriateness and feasibility of cognitive rehabilitation for people with dementias associated with Parkinson's in a pilot randomised controlled study.. To read the full article, log in using your SSSFT NHS OpenAthens details. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Open access. To examine the influence of the glucocerebrosidase (GBA) mutation carrier state on age at onset of Parkinson’s disease (PD), the motor phenotype and cognitive function at baseline assessment in a large cohort of UK patients. We also analysed the prevalence of mood and behavioural problems that may confound the assessment of cognitive function.
Individual motor improvement after deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson’s disease (PD) varies considerably. Stereotactic targeting of the dorsolateral sensorimotor part of the STN is considered paramount for maximising effectiveness, but studies employing the midcommissural point (MCP) as anatomical reference failed to show correlation between DBS location and motor improvement. The medial border of the STN as reference may provide better insight in the relationship between DBS location and clinical outcome.. To read the full article, log in using your NHS OpenAthens details.
In this prospective, longitudinal, multiparametric MRI study, we investigated clinical as well as brain grey matter and white matter (WM) regional changes in patients with progressive supranuclear palsy-Richardson’s syndrome (PSP-RS).. To read the full article, log in using your NHS OpenAthens details.
Depending on patient age at onset, absence epilepsy is subdivided into childhood and juvenile forms. Absence seizures can occur several times per day (pyknoleptic course) or less frequently than daily (non-pyknoleptic course). Seizures typically terminate before adulthood, but a quarter of patients need ongoing treatment beyond adolescence. Little is known about their long-term seizure and psychosocial outcome.. To read the full article, log in using your NHS OpenAthens details.
Stressful life events and maltreatment have traditionally been considered crucial in the development of conversion (functional neurological) disorder, but the evidence underpinning this association is not clear. We aimed to assess the association between stressors and functional neurological disorder.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Ketogenic diet therapies have proven efficacy for refractory epilepsy. There are many reports of their use in the genetic developmental and epileptic encephalopathies; however, little attention has been paid as to whether the diet is also effective in individuals with an acquired structural aetiology. . Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Editorial. Parkinson disease dementia (PDD) is one of the nonmotor complications of Parkinson disease, characterized by impairment of visuospatial and executive functions.1 The yearly incidence of PDD among patients with Parkinson disease is estimated at approximately 10%, but is widely variable in different reports.1,2 The risk of PDD increases with disease duration and patient age.3 Parkinson disease dementia is often complicated by many neuropsychiatric symptoms such as mood disturbances, apathy, and psychosis.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai