Antipsychotic medications, especially second-generation antipsychotics, have increasingly been prescribed to children under age 18 in the United States. They are approved to treat pediatric bipolar and psychotic disorders and aggressive behaviors among patients with autism, but they are often used off label to control disruptive behaviors of children without autism and treat mood problems of children without bipolar disorder.Login at top right hand side of page using your SSSFT NHS Athens for full text. SSOTP - request a copy of the article from the library http://www.sssft.nhs.uk/library
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There have been hints from previous literature that antidepressants taken by pregnant women may have an effect on fetal brain development, and specifically may predispose to autistic spectrum disorder (ASD). Researchers in Quebec used a registry covering the Province's entire population to try and establish whether such a link exists (Boukhris T, et al. JAMA Peds 2015. doi:10.1001/jamapediatrics.2015.3356). They identified over 145 000 infants born between 1998 and 2009, in whom they could analyse data on prescribing antidepressant drugs immediately before or during pregnancy. …..To read the full article, log in using your NHS OpenAthens details
Pharmacological treatments for agitation and aggression in patients with Alzheimer’s disease have shown limited efficacy. The authors assessed the heterogeneity of response to citalopram in the Citalopram for Agitation in Alzheimer Disease (CitAD) study to identify individuals who may be helped or harmed. Login at top right hand side of page using your SSSFT NHS Athens for full text. SSOTP - request a copy of the article from the library http://www.sssft.nhs.uk/library
19 January, 2016: The number of prescriptions dispensed in England for approved medicines (2) to treat Alzheimer's increased from 502,000 (3) in 2004 to 3.0 million in 2014. The cost to the NHS of prescriptions (4) for Alzheimer's disease medicines dispensed in primary care stood at £45.7m in 2014. This was up from £42.8m in 2004, but down from the high point it reached in 2011 of £110.8m (5).
The Cochrane Collaboration, known for their high-quality reviews and meta-analyses, recently published a systematic review of the efficacy of lithium as used to treat schizophrenia (Leucht et al, 2015).
Open access. Conclusion: The results clearly show that after one year of treatment with risperidone LAI, RSWG-remitted patients have a high level of global functioning, which is significantly higher than in stable, non-remitted patients. Social functioning was also higher in remitted patients as compared with stable, non-remitted patients.
Medication reconciliation (‘med rec’, as it is often called) refers to the ‘process of identifying the most accurate list of all medications a patient is taking … and using this list to provide correct medications for patients anywhere within the health system’.1 Two recent systematic reviews summarised the evidence for med rec interventions, finding that several med rec interventions reduced medication history errors and errors in patients’ admission and discharge medication regimens.2 ,3.....To read the full article, log in using your NHS OpenAthens details
A review of clinical study reports compiled by drug companies also suggests that risks may have been under-reported. Clinical study reports usually have more detail than the summaries of published trial results.
Researchers analysed 70 studies which looked at five antidepressants.
They looked specifically at the reports of deaths, suicides, suicidal thinking or suicide attempts, aggression, and a type of extreme restlessness called akathisia.
The results showed that children taking antidepressants had a higher chance of suicidal thoughts or suicide attempts, and of aggression. None of the children in the studied died. Adults in the studies did not have an increased risk of these problems.
A private member’s bill that would encourage UK doctors to try innovative treatments and consider the off-label use of drugs has passed its Commons stages with government support, and will go to the House of Lords. To read the full article, log in using your NHS Athens
Nearly one in 10 younger adults given antidepressants for depression or anxiety may have unrecognised bipolar disorder, a UK primary care study has shown. To read the full article, log in using your NHS Athens
Objective To explore medication-related burden (MRB) and patients’ lived experience with medicines (PLEM) without regard to particular medication therapies or medical conditions. Open Access Article
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Editorial. Login at top right hand side of page using your SSSFT NHS Athens for full text. SSOTP - request a copy of the article from the library http://www.sssft.nhs.uk/library
Editorial. Login at top right hand side of page using your SSSFT NHS Athens for full text. SSOTP - request a copy of the article from the library http://www.sssft.nhs.uk/library