PTSD, coping ability, positive outlook, proactive behavior, ability to evoke gratitude for what IS working, sense of hopefulness and efficacy, in women...
Armodafinil (Nuvigil®) is an eugeroic drug made by Cephalon, FDA-approved 6/15/2007. Clinical trials for its use in bipolar disorder, cognition in schizophrenia, excessive fatigue in Parkinson's & cancer, begin. Patent expires 2023.
Armodafinil From Wikipedia, the free encyclopedia Jump to: navigation, search Armodafinil Systematic (IUPAC) name (-)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide Identifiers CAS number 68693-11-8 ATC code N06BA07 PubChem ? Chemical data Formu
Weak willpower & procrastination caused by dopamine hypofunction is one of those neurological deficiencies which effort alone can't overcome. Happily, in our transhuman paradise, even the most lethargic spirit can move mountains.
Darwinian evolution has powerfully favoured the growth of ever more diverse, excruciating, but also more adaptive varieties of psychophysical pain. Its sheer nastiness effectively spurs and punishes the living vehicles of genetic replicators.
Here's just one: Even talking about posthuman psychological superhealth is morally frivolous. Another? Promoting superhappiness may lead to what one may call, informally, "inappropriate" behavioural responses.
Full-text, online textbook discussing various pharmaceutical, neutraceutical, and lifestyle interventions for enhancing life by facilitating our efforts to reach our fullest potential.
Modafinil induces wakefulness, but its dopamine-releasing action in the nucleus accumbens is weak and dose-dependent; no likelihood of euphoric response ('abuse potential').
A single protein in the brain influences arousal of despair, according to new study in mice. Brain biopsies revealed that mice trying hardest to escape shocks had highest levels of delta-FosB - which may also help humans avoid hopelessness & helplessness.
Unlike conventional stimulants, no anxiety, agitation and insomnia; selectively stimulates brain's adrenergic receptors for norepinephrine (noradrenaline), a neurotransmitter linked to alertness, learning, and memory.
Accounts of use for depression, ADD/ADHD, fibromyalgia, chronic fatigue (off-label). Metabolic precursor to modafinil; takes 1 hr to kick in, hard on liver. Not "controlled" like modafinil/Provigil.
depressed individuals actually have more realistic perceptions of their own image, importance, and abilities than the average person. While it’s still generally accepted that depressed people can be negatively biased in their interpretation of events an
Authorities report that more than half the population experiences trauma, which makes people more likely to develop PTSD, depression, anxiety and physical illness later in life. Now, a new study finds that among ‘healthy’ individuals, those who displa
A nonspecific immune reaction inducing a syndrome profile of fever, pain, anxiety, depression, reclusivity, anorexia, stress hormones, triggered by signals in the brain’s hypothalamus; body’s attempt to produce & preserve energy; cells secrete proinfl
Ketamine blocks a brain protein called the N-methyl-D-aspartic acid (NMDA) receptor. Previous studies have shown that agents that block the NMDA receptor reduce depression-like behaviors in animals.
This CURRENTLY ENROLLING study will test whether a single dose of ketamine - a drug that blocks a brain receptor called NMDA - can cause a rapid (next day) antidepressant effect in patients with major depression. Several medications are effective for trea
After reading Michael Fumento's article several points need to be made. In the first place, after clicking the link and reading the study itself, it bears emphasizing that the sample size-18 patients, is extremely small. This by definition makes it diffic
Dr. Zarate and colleagues said a single injection of ketamine, which targets the N-methlyl-D-aspartate (NMDA) receptor, can eliminate depression symptoms within 110 minutes.
17 depressed patients randomly assigned to receive either an injection of ketamine or a placebo. For 71% of those receiving the real deal, depression improved within a single day. Indeed, 29% became nearly free symptom free. Thirty-five percent of patient
A growing body of preclinical research suggests that brain glutamate systems may be involved in the pathophysiology of major depression and the mechanism of action of antidepressants. This is the first placebo-controlled, double-blinded trial to assess th
Ketamine is now being hailed by scientists as a breakthrough treatment for severe depressives. New research has found that patients who have failed to respond to more conventional drugs can be cured of depression within as little as two hours with an inje
The social avoidance that normally develops when a mouse repeatedly experiences defeat by a dominant animal disappears when it lacks a gene for a memory molecule in a brain circuit for social learning, scientists funded by the National Institutes of Healt
One of the characteristic manifestations of prolonged stress is decreased performance in tasks that require attention, including the ability to shift focus as well as to learn and unlearn information. Anxiety and depression can make a person feel as if he