Inflammation is a complex biological process in response to cellular perturbation or injury. It is manifest clinically as pain, heat (fever), redness, and loss of tissue function. It serves the important helpful role of initiating the elimination of tumor
scientists reported that a person's risk of a heart attack is doubled if he or she produces a particular version of FLAP, known more technically as 5-lipoxygenase activating protein. A troublesome variant of this protein boosts production of the inflammat
Central neuropeptides, including corticotropin releasing factor and perhaps substance P as well, initiate a systemic stress mobilization response by activating the sympathetic nervous system, hypothalamic pituitary axis, and the renin angiotensin system,
Inflammation destroys HA, and HA, injected into joints, decreases inflammation. In addition, it appears inflammation may reduce a cells ability to produce HA.
Inflammation: (Latin, inflammatio, to set on fire) is the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants.
Elevated levels of c-reactive protein (CRP) are known to be associated with insulin resistance and metabolic syndrome in adults. A substantial prevalence of hyperinsulinaemia and elevated CRP levels have been shown in Indian young adults.
Evidence emerged from studies in mice that hepcidin, a small peptide hormone exclusively produced in the liver in response to inflammation, could completely or nearly completely shut down normal iron hemostasis.
Evaluation of C-reactive protein, an inflammatory marker, and infectious serology as risk factors for coronary artery disease and myocardial infarction
While the cause of statin-associated myopathy is controversial, a central role for coenzyme Q10 (CoQ10 or ubiquinone) is slowly gaining acceptance. Statins have been shown to create an acquired CoQ10 deficiency.
Journal of Nutrition, Vol 128 No 2 February 1998 Muredach P Reilly, John A Lawson, and Garret A FitzGerald Center for Experimental Therapeutics, University of Pennsylvania School of Medicine Philadelphia, PA 19104
A relationship exists between cytokines and both leptin (L4146) and insulin ( I1507). Proinflammatory cytokines increase leptin levels while leptin regulates pro- and anti-inflammatory cytokine production.
Dr. Noboru Ashida, Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaramachi, Shogoin Sakyo-ku, Kyoto 606-8507, Japan. Voice +81-75-751-3465; fax: +81-75-751-3574; ash@kuhp.kyoto.u.ac.jp.
Accumulating evidence supports the hypothesis that chronic low-grade inflammation and activation of the innate immune system are closely involved in the pathogenesis of the type 2 diabetes.