Diverse nonhematopoietic biological effects of the cytokine erythropoietin shows that it promotes angiogenesis. Recombinant human erythropoietin therapy in prostate cancer will be studied...
Patients with cancer-related anaemia generally have a poor prognosis. Evidence suggests that an effective erythropoietic protein (epoetin)-mediated haemoglobin (Hb) response provides marked improvement in quality of life (QoL)...the use of an agent which
Evidence emerged from studies in mice that hepcidin, a small peptide hormone exclusively produced in the liver in response to inflammation, could completely or nearly completely shut down normal iron hemostasis.
Aging may be an intrinsic factor in the development of anemia, possibly through the age-related dysregulation of certain proinflammatory cytokines such as interleukin-6 (IL-6)...Increased IL-6 and other proinflammatory cytokines directly inhibit erythropo
Mind-boggling networks of cytokines and transcription factors have been invoked to explain the anemia of inflammation. Does it really have to be so complicated? Elevated hepcidin; defensive sequestering of serum ferritin (iron); direct cytokine disruption
Today we're going to discuss the anemia of inflammation -- starting with its mechanisms, then looking at a fairly new genetic link between inflammation and anemia, and including how we can apply all of this to our patients.
How does hepcidin promote anemia of inflammation? "When you have some sort of stimulation of hepatocytes, they make more hepcidin, which causes internalization and destruction of ferroportin, stopping any further absorption of iron," Dr. Rivera explained.
commonly observed in patients with chronic infections, malignancy, trauma, and inflammatory disorders...inflammatory cytokine IL-6 induces production of hepcidin, an iron-regulatory hormone that may be responsible...
Although in many cases the cause of anemia is not found, a primary deficiency of erythropoietin may be at fault in at least some of these cases since the response of erythropoietin to anemia may decrease in individuals over age 70. Conclusions: Anemia sh
Patients with chronic severe anaemia often retain salt and water. Fluid retention in these patients is not caused by heart failure and the exact mechanisms remain unclear.
Adjusting for confounders, we found that total and bioavailable testosterone levels were associated with hemoglobin levels in women and in men. Conclusion Older men and women with low testosterone levels have a higher risk of anemia.