user- We apply a simulational proxy of the -value analysis and perform extensive mutagenesis experiments to identify the nucleating residues in the folding “reac...We apply a simulational proxy of the -value analysis and perform extensive mutagenesis experiments to identify the nucleating residues in the folding “reactions” of two small lattice G polymers with different native geometries. Our findings show that for the more complex native fold (i.e., the one that is rich in nonlocal, long-range bonds), mutation of the residues that form the folding nucleus leads to a considerably larger increase in the folding time than the corresponding mutati...
- Long polyglutamine chains have been associated with a number of neurodegenerative diseases. These include Huntington's disease, where expanded polyglutamin...Long polyglutamine chains have been associated with a number of neurodegenerative diseases. These include Huntington's disease, where expanded polyglutamine (PolyQ) sequences longer than 36 residues are correlated with the onset of symptoms. In this paper we study the folding pathway of a 54-residue PolyQ chain into a -helical structure. Transition path sampling Monte Carlo simulations are used to generate unbiased reactive pathways between unfolded configurations and the folded -helical structu...
- Genome Biology (2005)
- Menopause 18(7):732-53 (July 2011)
- Proceedings of ICML-99, 16th International Conference on Machine Learning, page 200--209. Bled, SL, Morgan Kaufmann Publishers, San Francisco, US, (1999)
- Proceedings of the ACM SIGHIT International Health Informatics Symposium IHI 2012, Miami, Florida, USA, (2012)
- Proceedings of the ACM fifth international workshop on Data and text mining in biomedical informatics, page 43--50. New York, NY, USA, ACM, (2011)
- the 12th World Congress on Health Medical Informatics: 20-24 August 2007; Brisbane, Australia. Kuhn KA, Warren JR, Leong TY, editor. Amsterdam: IOS Press, page 550-554. Amsterdam, Kuhn KA, Warren JR, Leong TY, editor. Amsterdam: IOS Press, (2007)
- Proceedings of Tromsø Telemedicine and eHealth Conference, Tromsø, Norway, (2008)
- Am J Clin Nutr. 94(6):1575-83 (2011)
- Gynecologic Oncology (2011)
- Cochrane Database of Systematic Reviews 2011 (2011)
- Genes Nutr. 6(1):81-87 (2011)
- Molecular Nutrition & Food Research (2011)
- Current Pharmacogenomics and Personalized Medicine Formerly Current Pharmacog 7(2):106-114 (2009)
- Journal of the American Dietetic Association 108(11):1888 - 1895 (2008)
- Artif. Intell. 97(1-2):273--324 (1997)
- (1998)
- JOURNAL OF THE ASSOCIATION FOR INFORMATION SYSTEMS (2010)
- Proceedings of the NAACL HLT 2010 Workshop on Creating Speech and Language Data with Amazon’s Mechanical Turk, page 180–183. (2010)
- BMC Medical Informatics and Decision Making 10(1):56+ (Sep 28, 2010)
- (2011)
