%0 Journal Article %1 Woywodt.2004 %A Woywodt, A. %A Scheer, J. %A Hambach, L. %A Buchholz, S. %A Ganser, A. %A Haller, H. %A Hertenstein, B. %A Haubitz, M. %D 2004 %J Blood %K Adult Aged Agents Antineoplastic Case-Control Cell Cells Conditioning Count Diseases Endothelial Endothelium Factors Female Hematopoietic Homologous Humans Male Microcirculation Middle Radiotherapy Stem Studies Time Transplantation Vascular adverse cells diagnosis effects etiology methods pathology %N 9 %P 3603-3605 %T Circulating endothelial cells as a marker of endothelial damage in allogeneic hematopoietic stem cell transplantation %U PM:14715625 %V 103 %X Damage to endothelial cells is the common feature of vascular disorders associated with hematopoietic stem cell transplantation (HSCT). Elevated numbers of circulating endothelial cells reflect the extent of endothelial damage in a variety of disorders but their use in HSCT has not been investigated so far. We studied 39 patients undergoing allogeneic HSCT with different conditioning regimens and 22 healthy controls. Circulating endothelial cells were enumerated with immunomagnetic isolation during the course of HSCT. After conditioning, cell numbers were significantly elevated (median 44 cells/mL) compared with baseline (median 16 cells/mL) and controls (median 8 cells/mL). Patients who received radiation had an earlier peak when compared with patients who received chemotherapy. Patients who received reduced-intensity conditioning had significantly lower cell numbers (median 24 cells/mL) than those who received standard conditioning. These observations provide a novel marker to invest

@article{Woywodt.2004, abstract = {Damage to endothelial cells is the common feature of vascular disorders associated with hematopoietic stem cell transplantation (HSCT). Elevated numbers of circulating endothelial cells reflect the extent of endothelial damage in a variety of disorders but their use in HSCT has not been investigated so far. We studied 39 patients undergoing allogeneic HSCT with different conditioning regimens and 22 healthy controls. Circulating endothelial cells were enumerated with immunomagnetic isolation during the course of HSCT. After conditioning, cell numbers were significantly elevated (median 44 cells/mL) compared with baseline (median 16 cells/mL) and controls (median 8 cells/mL). Patients who received radiation had an earlier peak when compared with patients who received chemotherapy. Patients who received reduced-intensity conditioning had significantly lower cell numbers (median 24 cells/mL) than those who received standard conditioning. These observations provide a novel marker to invest}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Woywodt, A. and Scheer, J. and Hambach, L. and Buchholz, S. and Ganser, A. and Haller, H. and Hertenstein, B. and Haubitz, M.}, biburl = {https://www.bibsonomy.org/bibtex/26e260d77978a77035d039ae410cda044/kanefendt}, interhash = {c65abab83e101d6b275434983342e3ec}, intrahash = {6e260d77978a77035d039ae410cda044}, journal = {Blood}, keywords = {Adult Aged Agents Antineoplastic Case-Control Cell Cells Conditioning Count Diseases Endothelial Endothelium Factors Female Hematopoietic Homologous Humans Male Microcirculation Middle Radiotherapy Stem Studies Time Transplantation Vascular adverse cells diagnosis effects etiology methods pathology}, number = 9, pages = {3603-3605}, timestamp = {2010-02-05T11:28:42.000+0100}, title = {Circulating endothelial cells as a marker of endothelial damage in allogeneic hematopoietic stem cell transplantation}, url = {PM:14715625}, volume = 103, year = 2004 }