The CANHEART ‘big data’ research initiative is aimed at measuring and improving cardiovascular health and the quality of ambulatory cardiovascular care provided in Ontario, Canada using the population-based CANHEART cohorts. The CANHEART cohorts were created through the linkage of 19+ routinely collected health administrative, vital statistics, survey and laboratory databases housed at ICES. The strength of these cohorts lies in the large sample size, containing information on 9.8 million Ontarians age 20-105 years, and diversity of the linked databases.
Building upon the insights gained to date through the CANHEART work, we have recently launched a new CANHEART SPOR project aimed at leveraging big data to conduct innovative cardiovascular clinical trials. We aim to: 1) undertake a pragmatic cluster randomized registry-based clinical trial to improve lipid-management amongst intermediate-and high-risk patients residing in high-risk health regions in Ontario (called CHOICES), and 2) develop novel algorithms for measuring clinical outcomes in clinical trials using health-related databases and compare whether they are as accurate as traditional event ascertainment methods in a prospective clinical trial (called INVESTED). These projects will be undertaken by an interdisciplinary team consisting of experts in administrative health databases, implementation science, clinical trials, knowledge translation and patient engagement.
Open Journal of Preventive Medicine (OJPM) is an international journal dedicated to the latest advancement of Preventive Medicine. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of Preventive Medicine.
Open Journal of Molecular and Integrative Physiology (OJMIP) is an international journal dedicated to the latest advancement of Physiology. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of Physiology. All manuscripts must be prepared in English, and are subject to a rigorous and fair peer-review process.
Open Journal of Preventive Medicine (OJPM) is an international journal dedicated to the latest advancement of Preventive Medicine. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of Preventive Medicine. All manuscripts must be prepared in English, and are subject to a rigorous and fair peer-review process. Accepted papers will immediately appear online followed by printed hard copy.
Open Journal of Molecular and Integrative Physiology (OJMIP) is an international journal dedicated to the latest advancement of Physiology. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of Physiology. All manuscripts must be prepared in English, and are subject to a rigorous and fair peer-review process. Accepted papers will immediately appear online followed by printed hard copy.
We describe how innate and adaptive immune cascades trigger the release of cytokines and chemokines, resulting in the initiation and progression of atherosclerosis. We discuss how cytokines have direct and indirect effects on myocardial function.
Atherosclerosis is the predominant underlying pathology of cardiovascular disease...atherosclerotic lesions are characterized by abundance of immune cells and their effector molecules, eventually leading to unstable angina, myocardial infarction, or strok
The cellular and extracellular matrix accumulations that comprise the lesions of atherosclerosis are driven by local release of cytokines at sites of predilection for lesion formation, and by the specific attraction and activation of cells expressing rece
S. Stork, V. Boivin, R. Horf, L. Hein, M. Lohse, C. Angermann, and R. Jahns. Am Heart J, 152 (4):
697-704(October 2006)Stork, Stefan Boivin, Valerie Horf, Rudiger Hein, Lutz Lohse, Martin
J Angermann, Christiane E Jahns, Roland Research Support, Non-U.S.
Gov't United States American heart journal Am Heart J. 2006 Oct;152(4):697-704..
A. Paris, M. Philipp, P. Tonner, M. Steinfath, M. Lohse, J. Scholz, and L. Hein. Anesthesiology, 99 (4):
889-95(October 2003)Paris, Andrea Philipp, Melanie Tonner, Peter H Steinfath, Markus
Lohse, Martin Scholz, Jens Hein, Lutz Comparative Study Research
Support, Non-U.S. Gov't United States Anesthesiology Anesthesiology.
2003 Oct;99(4):889-95..
M. Lohse, and S. Engelhardt. Circ Res, 89 (11):
938-40(November 2001)Lohse, M J Engelhardt, S Comment Editorial United States Circulation
research Circ Res. 2001 Nov 23;89(11):938-40..
A. Knaus, X. Zong, N. Beetz, R. Jahns, M. Lohse, M. Biel, and L. Hein. Circulation, 115 (7):
872-80(February 2007)Knaus, Anne Zong, Xiangang Beetz, Nadine Jahns, Roland Lohse, Martin
J Biel, Martin Hein, Lutz Research Support, Non-U.S. Gov't United
States Circulation Circulation. 2007 Feb 20;115(7):872-80. Epub 2007
Jan 29..
M. Bunemann, K. Lee, R. Pals-Rylaarsdam, A. Roseberry, and M. Hosey. Annu Rev Physiol, (1999)Bunemann, M Lee, K B Pals-Rylaarsdam, R Roseberry, A G Hosey, M M
Review United states Annual review of physiology Annu Rev Physiol.
1999;61:169-92..
M. Bunemann, B. Brandts, D. zu Heringdorf, C. van Koppen, K. Jakobs, and L. Pott. J Physiol, (December 1995)Bunemann, M Brandts, B zu Heringdorf, D M van Koppen, C J Jakobs,
K H Pott, L In Vitro Research Support, Non-U.S. Gov't England The
Journal of physiology J Physiol. 1995 Dec 15;489 ( Pt 3):701-7..