Long polyglutamine chains have been associated with a number of neurodegenerative diseases. These include Huntington's disease, where expanded polyglutamine (PolyQ) sequences longer than 36 residues are correlated with the onset of symptoms. In this paper we study the folding pathway of a 54-residue PolyQ chain into a -helical structure. Transition path sampling Monte Carlo simulations are used to generate unbiased reactive pathways between unfolded configurations and the folded -helical structu...
M. Atzmueller, L. Thiele, G. Stumme, и S. Kauffeld. Proc. Annual Machine Learning Conference of the Benelux (Benelearn 2017), Eindhoven, The Netherlands, Eindhoven University of Technology, (2017)
M. Atzmueller, L. Thiele, G. Stumme, и S. Kauffeld. Proc. Annual Machine Learning Conference of the Benelux (Benelearn 2017), Eindhoven, The Netherlands, Eindhoven University of Technology, (2017)
M. Atzmueller, L. Thiele, G. Stumme, и S. Kauffeld. Proc. Annual Machine Learning Conference of the Benelux (Benelearn 2017), Eindhoven, The Netherlands, Eindhoven University of Technology, (2017)
M. Atzmueller, S. Doerfel, A. Hotho, F. Mitzlaff, и G. Stumme. Modeling and Mining Ubiquitous Social Media - International Workshops MSM 2011, Boston, MA, USA, October 9, 2011, and MUSE 2011, Athens, Greece, September 5, 2011, Revised Selected Papers, том 7472 из Lecture Notes in Computer Science, Springer Berlin Heidelberg, Heidelberg, Germany, (2012)