Prospective population based-registers of amyotrophic lateral sclerosis (ALS) have operated in Europe for over two decades, and have provided important insights into our understanding of ALS. Here, we review the benefits that population registers have brought to the understanding of the incidence, prevalence, phenotype and genetics of ALS and outline the core operating principles that underlie these registers and facilitate international collaboration. Going forward, we offer lessons learned from our collective experience of operating population-based ALS registers in Europe for over two decades, focusing on register design, maintenance, identification and management of bias and the value of cross-national harmonisation and integration. To read the full article, log in using your NHS OpenAthens details.
Mrs and Mr Willis are coming back from shopping, hands full of grocery bags for the upcoming dinner. Their son-in-law is unlocking the door, but he seems to have difficulties as he repeatedly tries to handle the keys. No, he is not already tipsy before dinner! Unlocking the door can be quite challenging for someone with small hand muscle palsy....... To read the full article, log in using your NHS OpenAthens details.
Approximately 30% of patients with amyotrophic lateral sclerosis (ALS) have cognitive impairment and 8%–14% fulfil the criteria for behavioural variant frontotemporal dementia (bv-FTD). The cognitive profiles of ALS and bv-FTD have been reported to be comparable, but this has never been systematically investigated. We aimed to determine the cognitive profile of bv-FTD and examine its similarities with that of ALS, to provide evidence for the existence of a cognitive disease continuum encompassing bv-FTD and ALS.. To read the full article, log in using your NHS OpenAthens details.
Families require more specialised support to manage behaviours of concern following acquired brain injury within community settings. Evidence supports the involvement of family caregivers in behaviour interventions, however there are no validated behaviour support approaches for individuals with acquired brain injury emphasising family involvement. To read the full article, log in using your MPFT NHS OpenAthens details.
Active lifelong cognitive lifestyles increase cognitive reserve and have beneficial effects on global cognition, cognitive decline and dementia risk in Parkinson's disease (PD). Executive function is particularly impaired even in early PD, and this impacts on quality of life. The effects of lifelong cognitive lifestyle on executive function in PD have not been studied previously. This study examined the association between lifelong cognitive lifestyle, as a proxy measure of cognitive reserve, and executive function in people with PD. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
To examine psychometric properties and clinical utility of the Functional Communication Classification System (FCCS) for classifying observable communication function in children with cerebral palsy (CP) aged 5 to 18 years.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
This commentary is on the original article by Ek et al. To view this paper visit https://doi.org/10.1111/dmcn.14163.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
The development of a nurse‐led approach to managing epilepsy in adults with an intellectual disability (ID) offers the potential of improved outcomes and lower costs of care. We undertook a cluster randomised trial to assess the impact on costs and outcomes of the provision of ID nurses working to a designated epilepsy nurse competency framework. Here, we report the impact of the intervention on costs.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
This commentary is on original article by Oh et al. To view this paper visit https://doi.org/10.1111/dmcn.14174.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Hypertension, dyslipidemia, diabetes, and obesity are well-established risk factors for cognitive impairment and dementia in older adults. In contrast, previous studies that have assessed the impact of vascular risk factors (VRFs) on cognition in Parkinson's disease (PD) have had methodological limitations and reported conflicting findings. We address this question in a large well-characterized cohort of de novo PD patients. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
With the subspecialisation of psychiatry in the UK, clinicians may encounter problems at the interface between specialties. This article focuses on the interface between general adult psychiatry and behavioural neurology/neuropsychiatry. Important interface issues include the identification of psychiatric symptoms in patients with organic brain pathology and the remit and organisation of general and specialist services. Options for optimum cooperation are presented alongside practical examples of clinical issues of neuropsychiatric relevance. Login using your SSSFT NHS OpenAthens for full text. SSOTP - request a copy of the article from the library - www.sssft.nhs.uk/library
Open access. Patients with Parkinson’s disease (PWP) have complex healthcare needs, and compared to the general population, are more likely to have an unplanned emergency department (ED) attendance to hospital, along with poorer outcomes. Innovative methods of notification, when patients have an ED attendance are needed to allow for earlier specialist team interventions. This study describes the introduction of an email alert (e-alert) for a specialist Parkinson’s team in Wales. In addition, the reason for admission, specialist team interventions, length of stay, frequency of readmission, discharge destination, mortality and the bed cost per ED attendance or admission episode will be explored.
Ketogenic diet therapies have proven efficacy for refractory epilepsy. There are many reports of their use in the genetic developmental and epileptic encephalopathies; however, little attention has been paid as to whether the diet is also effective in individuals with an acquired structural aetiology. . Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Letter. Impulsive compulsive behaviours (ICBs) such as dopamine dysregulation syndrome (DDS), pathological gambling, compulsive sexual behaviour, punding, compulsive shopping and binge eating are recognised complications of dopaminergic treatment that affect at least one in seven patients with Parkinson’s disease (PD).1 Only a few studies provide long-term data on ICBs although any firm conclusions are limited by restricted follow-up periods. We present long-term longitudinal data on 46 PD patients with ICBs with follow-up for a mean period of 8.2 years.. To read the full article, log in using your NHS OpenAthens details.
Letter. Impulsive compulsive behaviours (ICBs) such as dopamine dysregulation syndrome (DDS), pathological gambling, compulsive sexual behaviour, punding, compulsive shopping and binge eating are recognised complications of dopaminergic treatment that affect at least one in seven patients with Parkinson’s disease (PD).1 Only a few studies provide long-term data on ICBs although any firm conclusions are limited by restricted follow-up periods. We present long-term longitudinal data on 46 PD patients with ICBs with follow-up for a mean period of 8.2 years.. To read the full article, log in using your NHS OpenAthens details.
The diagnosis of delirium depends on eliciting its features through mental status examination and informant history. However, there is marked heterogeneity in how these features are assessed, from binary subjective clinical judgement to more comprehensive methods supported by cognitive testing. The aim of this article is to review the neuropsychological research in delirium and suggest future directions in research and clinical practice. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
To develop an easily‐administered metric to quantify gait impairment in children and to assess its use in children with cerebral palsy (CP).. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Zumba Gold® is a dance-based workout developed for older adults that could be beneficial for mobility and well-being in people Parkinson’s (PD). However, to date there is no evidence to support the suitability of this type of exercise in people with PD. To read the full article, log in using your NHS OpenAthens details
Open access. The field of prediagnostic Parkinson's disease (PD) is fast moving with an expanding range of clinical and laboratory biomarkers, and multiple strategies seeking to discover those in the earliest stages or those ‘at risk’. It is widely believed that the highest likelihood of securing neuroprotective benefit from drugs will be in these subjects, preceding current point of diagnosis of PD
Open access. The field of prediagnostic Parkinson's disease (PD) is fast moving with an expanding range of clinical and laboratory biomarkers, and multiple strategies seeking to discover those in the earliest stages or those ‘at risk’. It is widely believed that the highest likelihood of securing neuroprotective benefit from drugs will be in these subjects, preceding current point of diagnosis of PD. In this review, we outline current knowledge of the prediagnostic phase of PD, including an up-to-date review of risk factors (genetic and environmental), their relative influence, and clinical features that occur prior to diagnosis.
Neuropsychology31.6 (Sep 2017): 596-604.
Objective: Parkinson’s disease (PD) has long been conceptualized as a motor disorder, but nonmotor symptoms also manifest in the disease and significantly reduce quality of life. Anxiety and cognitive dysfunction are prevalent nonmotor symptoms, even in early disease stages, but the relation between these symptoms remains poorly understood. We examined self-reported anxiety and neurocognitive function, indexed by measures of executive function (set-shifting and phonemic fluency), categorical fluency, and attention/working memory. To read the full article, log in using your NHS OpenAthens details.
Repeated consciousness-impairing seizures weaken the reticular activating system’s connections, possibly leading to the baseline neurocognitive dysfunction these patients experience. To read the full article, log in using your NHS OpenAthens details.
Editorial commentary: How does the localised ictal activity of a temporal lobe seizure generate a global impairment of consciousness? And how do brief temporal lobe seizures beget long-lasting interictal changes in cognition? Dr Englot and his colleagues have pursued these questions over the past decade through several innovative studies, and have convincingly implicated the ascending reticular activating system (ARAS) as an important contributor.1–3 In their most recent JNNP study4, they further incriminate the ARAS, although now as a source of interictal neurocognitive impairment. To read the full article, log in using your NHS OpenAthens details.
ALS is the unifying term for this heterogeneous syndrome and time to question the dogma forged at El Escorial. Historically characterised as a neuromuscular disease involving progressive loss of both central and peripheral motor neurons, amyotrophic lateral sclerosis (ALS) now sits among the cerebral neurodegenerative syndromes, involving clinical, pathological and genetic overlap with frontotemporal dementia (FTD). Descriptions of progressive lower motor neuron degeneration and associated muscle wasting, termed progressive muscular atrophy (PMA), were published by anatomists such as Charles Bell as early as 1836. . To read the full article, log in using your NHS OpenAthens details.
Atomoxetine selectively inhibits the reuptake of norepinephrine. Given the noradrenergic system's role in executive function, pharmacotherapy options that affect norepinephrine are of particular clinical interest in Parkinson disease–related executive dysfunction. . MPFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Annual epilepsy reviews can provide substantial benefits for people living with epilepsy, and practice nurses are ideally placed to undertake them. Pamela Mantri explains how a review can be undertaken and signposts useful resources for more information. To read the full article, log in using your MPFT NHS OpenAthens details.
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Open access. The aims of this study were twofold: first, to develop and validate a timed test of unimanual and bimanual dexterity suitable for those with disability affecting hand function; second, to explore relationships between unimanual and bimanual completion times.
The neurodegenerative syndrome amyotrophic lateral sclerosis (ALS) is characterised by increased cortical excitability, thought to reflect pathological changes in the balance of local excitatory and inhibitory neuronal influences. Non-invasive brain stimulation (NIBS) has been shown to modulate cortical activity, with some protocols showing effects that outlast the stimulation by months. NIBS has been suggested as a potential therapeutic approach for disorders associated with changes in cortical neurophysiology, including ALS. This article reviews NIBS methodology, rationale for its application to ALS and progress to date.. To read the full article, log in using your NHS OpenAthens details.
Experts from 13 national bodies, including seven Royal Colleges, have joined forces to launch new practical guidance to support doctors and other health professionals around valproate use in women and girls in their reproductive years.
Open access. The Journal of Neurology, Neurosurgery & Psychiatry brought together a panel of experts on World MS Day 2017 to discuss the importance of time in MS—timing of initiation and withdrawal of disease-modifying treatment, time to consider contributory factors such as vascular disease, and the time and cost burden of MS. This paper, which originated in the round table discussion, reviews the following: latest thinking in timing of disease management; how treatment and prevention of vascular injury may buy additional time for people with MS; new data about the true economic and social burden of the disease for people with MS and their carers.
Open access. The Journal of Neurology, Neurosurgery & Psychiatry brought together a panel of experts on World MS Day 2017 to discuss the importance of time in MS—timing of initiation and withdrawal of disease-modifying treatment, time to consider contributory factors such as vascular disease, and the time and cost burden of MS. This paper, which originated in the round table discussion, reviews the following:
latest thinking in timing of disease management; how treatment and prevention of vascular injury may buy additional time for people with MS; new data about the true economic and social burden of the disease for people with MS and their carers.
Editorial. Status epilepticus (SE) is a very common neurological emergency in children.1,2 Refractory convulsive SE (RCSE) is characterized by the persistence of convulsive seizures or evolution of the convulsive seizure to nonconvulsive seizures event after initial antiseizure treatment.3 Children presenting in RCSE account for a high percentage of morbidity and mortality.3-5 In one study, the mortality was 32% for children with RCSE.4. . Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Several oral β-blockers are US Food and Drug Administration–approved for migraine prophylaxis, but their gradual absorption and modification by first-pass metabolism delays effective plasma levels for hours to days, limiting their use in acute migraines.1 Timolol eyedrops provide a rapid route of delivery with the maximum plasma concentration achieved within 15 minutes of administration.2,3 This pharmacokinetic advantage supports a potential role for timolol eyedrops in managing acute migraine.4,5. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
There are few reports on the tolerability and efficacy of perampanel, a new antiepileptic drug with a novel mechanism of action, in children and adolescents. We aimed to describe our experience with perampanel add-on and mono-therapy in children with refractory epilepsy. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Tourette syndrome is a complex neuropsychiatric disorder of juvenile onset, characterised by motor and phonic tics. It is associated with a number of comorbid psychiatric conditions and a reduced quality of life in the young person and with parenting stress, caregiver burden and psychopathology in the parents. The global prevalence (about 1%) is higher than previously thought, with a strong male preponderance. Evidence is emerging that Tourette syndrome is not a unified disorder; rather, it encompasses a number of subtypes, characterised by complexity of tics and the simultaneous presence of other behaviours or disorders. This article discusses the aetiology of the syndrome, and examines its clinical features and comorbid psychiatric conditions and psychopathologies. Assessment and diagnosis are also discussed. Psychoeducation is a cornerstone of management, augmented with behavioural and/or pharmacological treatments. Newer therapies, such as deep brain stimulation, offer tantalising possibilities, but further research is still needed. Login using your SSSFT NHS OpenAthens for full text. SSOTP - request a copy of the article from the library - http://bit.ly/1Xyazai
In this prospective, longitudinal, multiparametric MRI study, we investigated clinical as well as brain grey matter and white matter (WM) regional changes in patients with progressive supranuclear palsy-Richardson’s syndrome (PSP-RS).. To read the full article, log in using your NHS OpenAthens details.
Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical course and outcome. Intravenous immunoglobulin (IVIg) and plasma exchange are proven effective treatments, but the efficacy has been demonstrated mainly on motor improvement in adults with a typical and severe form of GBS. In clinical practice, treatment dilemmas may occur in patients with a relatively mild presentation, variant forms of GBS, or when the onset of weakness was more than 2 weeks ago. Other therapeutic dilemmas may arise in patients who do not improve or even progress after initial treatment. We provide an overview of the current literature about therapeutic options in these situations, and additionally give our personal view that may serve as a basis for therapeutic decision-making. To read the full article, log in using your NHS OpenAthens details.
Letter. . SSSFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Essential tremor is the most common cause of tremor involving upper limbs, head and voice. The first line of treatment for limb tremor is pharmacotherapy with propranolol or primidone. However, these two drugs reduce the tremor severity by only half. In medication refractory and functionally disabling tremor, alternative forms of therapy need to be considered. Botulinum toxin injections are likely efficacious for limb, voice and head tremor but are associated with side effects. Surgical interventions include deep brain stimulation; magnetic resonance-guided focused ultrasound and thalamotomy for unilateral and deep brain stimulation for bilateral procedures. Recent consensus classification for essential tremor has included a new subgroup, ‘Essential tremor plus’, who have associated subtle neurological ‘soft signs’, such as dystonic posturing of limbs and may require a different treatment approach. In this review, we have addressed the current management of essential tremor with regard to different anatomical locations of tremor as well as different modalities of treatment.... To read the full article, log in using your NHS OpenAthens details.
A study published in 2000 showed that more than one-third of adults with epilepsy have inadequate control of seizures with antiepileptic drugs (AEDs). This study evaluates overall treatment outcomes in light of the introduction of more than 1 dozen new AEDs in the past 2 decades.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Despite the success of epilepsy surgery, recent reports suggest a decline in surgical numbers. We tested these trends in our cohort to elucidate potential reasons. To read the full article, log in using your NHS OpenAthens details.
Last week Trusts from Cornwall and Somerset met to look at how their services meet the needs of those living with a learning disability and epilepsy.
Cornwall Partnership NHS Foundation Trusts (CFT) Learning Disability Epilepsy Team met with staff from Somerset Partnership NHS Foundation Trust Community Learning Disability Team to look at how their services work to meet the needs of their patients and the different models of service design from a patient perspective.
Young people with type 1 diabetes have three times the risk of developing epilepsy later in life, research concludes. To read the full article, log in using your NHS OpenAthens details
Open access. Traumatic brain injury (TBI) leads to increased rates of dementia, including Alzheimer’s disease. The mechanisms by which trauma can trigger neurodegeneration are increasingly understood. For example, diffuse axonal injury is implicated in disrupting microtubule function, providing the potential context for pathologies of tau and amyloid to develop. The neuropathology of post-traumatic dementias is increasingly well characterised, with recent work focusing on chronic traumatic encephalopathy (CTE). However, clinical diagnosis of post-traumatic dementia is problematic. It is often difficult to disentangle the direct effects of TBI from those produced by progressive neurodegeneration or other post-traumatic sequelae such as psychiatric impairment. CTE can only be confidently identified at postmortem and patients are often confused and anxious about the most likely cause of their post-traumatic problems.
To identify the type and extent of unmet needs in people with Parkinson's disease and to examine the impact of health locus of control and family support on these needs.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Tremor is a common neurological condition in clinical practice; yet, few syndromes are widely recognised and discussed in the literature. As a result, there is an overdiagnosis of well-known causes, such as essential tremor. Many important unusual syndromes should be considered in the differential diagnosis of patients with tremor. The objective of this review is to provide broad clinical information to aid in the recognition and treatment of various unusual tremor syndromes in the adult and paediatric populations. To read the full article, log in using your NHS OpenAthens details.
Epilepsy is a common neurological disorder, prevalent in about 1% of the population. Almost half of the patients with epilepsy are women. Epilepsy and antiepileptic drugs can affect each aspect of the female human life cycle which includes menstrual cycle, contraception, fertility, conception, pregnancy and menopause. The interplay of the female hormonal state and epilepsy is complex and has to be taken in to consideration when managing their epilepsy. This review focuses on the management of women with epilepsy related to their role in reproduction. To read the full article, log in using your NHS OpenAthens details
Epilepsy is a common neurological disorder, prevalent in about 1% of the population. Almost half of the patients with epilepsy are women. Epilepsy and antiepileptic drugs can affect each aspect of the female human life cycle which includes menstrual cycle, contraception, fertility, conception, pregnancy and menopause. The interplay of the female hormonal state and epilepsy is complex and has to be taken in to consideration when managing their epilepsy. This review focuses on the management of women with epilepsy related to their role in reproduction. To read the full article, log in using your NHS OpenAthens details.
Open access. To examine the relationships between upper limb impairments and independence in self‐care (ISC) in children with unilateral cerebral palsy (CP).
Patients with cerebral palsy (CP), especially those at the severe end of the spectrum (Gross Motor Function Classification System levels IV–V equivalent), frequently suffer from sleep disturbance and sleep-disordered breathing (SDB). Non-invasive ventilation (NIV) is increasingly used in this patient group, albeit with little published evidence of its effectiveness in CP. This article aims to review the current evidence in the use of NIV in children with CP, highlighting areas of uncertainties, as well as the balance of potential risks, challenges and benefits.. To read the full article, log in using your NHS OpenAthens details.
If a woman is prescribed valproate, she must use highly effective contraception, so she does not get pregnant.
Some woman with intellectual disabilities and epilepsy and/ or mood problems who take this medicine may need help in understanding that they must use contraception.
Doctors, nurses and other health and social care workers all need to know about this so that they can advise women with intellectual disabilities of the dangers. . To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Surveys of patients with multiple sclerosis report that most are interested in modifying their diet and using supplements to potentially reduce the severity and symptoms of the disease. This review provides an updated overview of the current state of evidence for the role that vitamins and dietary supplements play in multiple sclerosis and its animal models, with an emphasis on recent studies, and addresses biological plausibility and safety issues.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Our aim was to ascertain the indications, side effects, and outcomes in children receiving therapeutic plasma exchange (TPE) for neurological disorders.. To read the full article, log in using your MPFT NHS OpenAthens details.
In 2017, the diagnostic criteria for cognitive and behavioural impairment in amyotrophic lateral sclerosis (ALS) with frontotemporal dementia (ALSFTD-1) have been modified (ALSFTD-2) with the inclusion of a novel category (ALS with combined cognitive and behavioural impairment, ALScbi) and with changes of operational criteria of the other categories (ALS with cognitive impairment (ALSci), ALS with behavioural impairment (ALSbi) and ALS with frontotemporal dementia (ALS-FTD)). We compared the two sets of criteria to assess the effect of the revised criteria on the cognitive classification of patients with ALS.. To read the full article, log in using your NHS OpenAthens details.
Although use of valproate medicines in female patients continues to slowly decline, there is wide variation in prescribing between Clinical Commissioning Groups (CCGs). Women continue to report instances when they have not received patient information with their dispensed valproate medicine. All healthcare professionals must continue to identify and review all female patients on valproate, including when it is used outside the licensed indications (off-label use) and provide them with the patient information materials every time they attend their appointments or receive their medicines (including the Patient Information Leaflet at dispensing).
Blood-brain barrier (BBB) disruption has long been recognised as an important early feature of multiple sclerosis (MS) pathology. Traditionally, this has been seen as a by-product of the myelin-specific immune response. Here, we consider whether vascular changes instead play a central role in disease pathogenesis, rather than representing a secondary effect of neuroinflammation or neurodegeneration. To read the full article, log in using your NHS OpenAthens details.
Blood-brain barrier (BBB) disruption has long been recognised as an important early feature of multiple sclerosis (MS) pathology. Traditionally, this has been seen as a by-product of the myelin-specific immune response. Here, we consider whether vascular changes instead play a central role in disease pathogenesis, rather than representing a secondary effect of neuroinflammation or neurodegeneration. To read the full article, log in using your NHS OpenAthens details.
Objectives: Describe novel methods for ascertaining verbal fluency in a large national sample of adults, examine demographic factors influencing performance, and compare scores to studies using in‐person assessment.
Methods/Design: Participants were from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, a national, population‐based, longitudinal study of stroke in adults aged 45 years an older.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Visual hallucinations (VHs) can occur in several clinical conditions, of which the dementias, broadly defined, and Parkinson's disease rank among the most common. There is limited research on the lived experience of hallucinations among affected individuals and therefore a lack of evidence‐based management strategies. This study used qualitative methods to explore the VH experience of individuals with dementia or Parkinson's disease and their informal caregivers.. To read the full article, log in using your MPFT NHS OpenAthens details. SSOTP (legacy account) - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
The research suggests that strobe lighting at festivals might increase the risk of seizures for people predisposed to photosensitive epilepsy.
For that reason it would be sensible for people who have photosensitive epilepsy to take precautions to avoid seizures by avoiding events with strobe lighting, being aware of early warning "aura" symptoms, and being ready to leave events if they start to feel unwell.
Psychogenic non-epileptic seizures (PNES) are involuntary paroxysmal events that are unaccompanied by epileptiform EEG discharges. We hypothesised that PNES are a disorder of distributed brain networks resulting from their functional disconnection.The disconnection may underlie a dissociation mechanism that weakens the influence of unconsciously presented traumatising information but exerts maladaptive effects leading to episodic failures of behavioural control manifested by psychogenic ‘seizures’. To read the full article, log in using your NHS OpenAthens details
To identify the barriers and facilitators to goal-setting during rehabilitation for stroke and other acquired brain injuries. To read the full article, log in using your NHS OpenAthens details
Editorial commentary. Is ALS simply a collection of single, unique rare diseases with a discrete monogenetic cause, or is it a diagnostic continuum with a complex contribution of thousands of genetic and environmental factors? This is one of the most fundamental questions that are still unanswered in ALS. . To read the full article, log in using your NHS OpenAthens details.
Unilateral visual neglect is characterised by lateralised spatial–attentional deficits, resulting in dramatic behavioural impairments.1 Neglect negatively impacts functional outcome and needs to be successfully detected in order to inform neglect-specific as well as general post-stroke rehabilitation goals and strategies. It is therefore critically important to evaluate current clinical methods for detecting and measuring the extent of this syndrome.. To read the full article, log in using your NHS OpenAthens details.
Patients with functional neurological symptoms are often suspected of feigning their symptoms. These suspicions have been reported not only in the doctors1 and nurses2 who treat them, but also in the general public who commonly infer that patients described as having functional symptoms are simply pretending to be sick.3 We found that limited education was an important determinant in who made this inference, and that even very simple additional explanation substantially reduced it. To read the full article, log in using your NHS OpenAthens details.
It's very hard to be sure of the exact level of risk that may be associated with any class or individual drug.
It's also worth considering that this study has looked at people prescribed anticholinergics in older age who were diagnosed with dementia at around 82 years. We cannot apply this data to give the risk for a younger adult taking one of these drugs.
Two £25 vouchers are up for grabs in the library’s ‘Making the Most of Information’ survey.
To take part, just visit http://goo.gl/AdN4ok by Friday 19th February.
To investigate the feasibility of a full-scale randomised controlled trial of a picture booklet to improve quality of life for people with epilepsy and learning disabilities. Open Access Article
Neuropsychology (Oct 18, 2018). DOI:10.1037/neu0000498
Objective: Symptoms of anxiety, depression commonly co-occur with cognitive decline in patients with Parkinson’s disease (PD). The directionality of this association is unclear, however, in that poor cognitive performance may lead to increased symptoms of anxiety and depression or higher anxiety and depressive symptoms may lead to cognitive decline. The purpose of this study was to elucidate the directionality of the association between symptoms of anxiety and depression with cognitive performance in newly diagnosed patients with PD.. To read the full article, log in using your NHS OpenAthens details.
X linked Charcot-Marie-Tooth disease (CMTX) is a hereditary neuropathy caused by mutations in GJB1 coding for connexin-32, a gap junction protein expressed in Schwann cells, but also found in oligodendrocytes. Four patients with CMTX developing central nervous system (CNS) demyelination compatible with multiple sclerosis (MS) have been individually published. We presently sought to systematically investigate the relationship between CMTX and MS.. To read the full article, log in using your NHS OpenAthens details.
Open access. Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease of motor neurons with a median survival of 2 years. Familial ALS has a younger age of onset than apparently sporadic ALS. We sought to determine whether this younger age of onset is a result of ascertainment bias or has a genetic basis.