To investigate clinical and radiological outcomes of women with relapsing-remitting multiple sclerosis (RRMS) undergoing abortion. . To read the full article, log in using your NHS OpenAthens details.
Depending on patient age at onset, absence epilepsy is subdivided into childhood and juvenile forms. Absence seizures can occur several times per day (pyknoleptic course) or less frequently than daily (non-pyknoleptic course). Seizures typically terminate before adulthood, but a quarter of patients need ongoing treatment beyond adolescence. Little is known about their long-term seizure and psychosocial outcome.. To read the full article, log in using your NHS OpenAthens details.
Depending on patient age at onset, absence epilepsy is subdivided into childhood and juvenile forms. Absence seizures can occur several times per day (pyknoleptic course) or less frequently than daily (non-pyknoleptic course). Seizures typically terminate before adulthood, but a quarter of patients need ongoing treatment beyond adolescence. Little is known about their long-term seizure and psychosocial outcome.. To read the full article, log in using your NHS OpenAthens details.
Open access. Deep brain stimulation (DBS) for Parkinson's disease (PD) is currently limited by costs, partial efficacy and surgical and stimulation-related side effects. This has motivated the development of adaptive DBS (aDBS) whereby stimulation is automatically adjusted according to a neurophysiological biomarker of clinical state, such as β oscillatory activity (12–30 Hz). aDBS has been studied in parkinsonian primates and patients and has been reported to be more energy efficient and effective in alleviating motor symptoms than conventional DBS (cDBS) at matched amplitudes.1 ,2
However, these studies have not considered whether side effects can also be avoided with clinically effective stimulation. In PD, it is well recognised that a significant proportion of patients develop speech deterioration following DBS of the subthalamic nucleus (STN), which may be reversible.3
Here we test bilateral stimulation, optimising parameters for aDBS, and evaluate speech intelligibility. We hypothesised that acute aDBS would be more effective and more efficient than cDBS at matched stimulation parameters while causing less speech impairment.
To characterize the adaptive behavior profile of children with neurofibromatosis type 1 (NF1) and determine its relationship to neuropsychological functioning and non‐neoplastic T2‐weighted hyperintense brain lesions on brain magnetic resonance imaging (MRI).. To read the full article, log in using your MPFT NHS OpenAthens details.
Sexuality and intimacy are poorly researched in both people living with Parkinson's and in older people. Triggers for discussion usually centre on sexual dysfunction and hypersexuality in relation to Parkinson's. However, there are many more factors that impact on physical and emotional connectedness. Despite highlighting this unmet need there are limited tools or comprehensive assessments available to help improve quality of life. To read the full article, log in using your MPFT NHS OpenAthens details.
This systematic review aims to assess the safety profile of oxcarbazepine during pregnancy. It will help healthcare providers and guideline developers regarding the treatment of epilepsy and other neurological disorders during pregnancy. To read the full article, choose “Institutional Login” and search for “Midlands Partnership”.
Editorial commentary: Lacey and colleagues take the innovative approach of using linkage of routine-collected health and national education data to carry out a matched case–control study to assess educational attainment of children born to mothers with epilepsy1. Their main finding was in utero exposure to antiepileptic drugs (AED) in combination, or sodium valproate alone, is associated with a significant decrease in attainment in national educational tests for 7-year-old children compared with both the matched control group and the all-Wales national average. Arguably, at first glance, this may not seem like news per se but there are several points that make it highly noteworthy........ To read the full article, log in using your NHS OpenAthens details.
This study sought to: (1) determine what is known about age at referral for diagnosis and rehabilitation services for children suspected of having cerebral palsy (CP); and (2) identify factors associated with earlier referral.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Dementia with Lewy bodies (DLB) is characterised by neuroleptic hypersensitivity. It is unclear, however, whether the neuroleptic hypersensitivity implies an increased incidence of neuroleptic malignant syndrome (NMS) or of akinetic crisis (AC), which are expressions of the same possibly lethal clinical event, and whether AC in DLB can appear independently of neuroleptic treatment. In our prospective study, we assessed the incidence of AC in a cohort of DLB as compared with that in patients with Parkinson disease (PD). To read the full article, log in using your NHS OpenAthens details
Dementia with Lewy bodies (DLB) is characterised by neuroleptic hypersensitivity. It is unclear, however, whether the neuroleptic hypersensitivity implies an increased incidence of neuroleptic malignant syndrome (NMS) or of akinetic crisis (AC), which are expressions of the same possibly lethal clinical event, and whether AC in DLB can appear independently of neuroleptic treatment. In our prospective study, we assessed the incidence of AC in a cohort of DLB as compared with that in patients with Parkinson disease (PD). To read the full article, log in using your NHS OpenAthens details.
The aim of this study was to evaluate the feasibility of implementing the Parkinson Wellness Recovery Moves intervention into the treatment of patients with Parkinson's disease, within an inpatient rehabilitation hospital. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Question Is uncomplicated childhood-onset epilepsy associated with increased brain amyloid accumulation?
Findings In this population-based case-control study of Finnish adults who had childhood epilepsy and were followed up prospectively for more than 50 years from their disease onset and a group of matched controls, individuals with childhood-onset epilepsy, and particularly APOE ε4 carriers, had an increased brain amyloid load as measured with positron emission tomography at late middle age.
Meaning Childhood-onset epilepsy is linked with a biomarker that might be associated with accelerated brain aging and can be considered as a neurobiological predisposition to later-life cognitive disorders. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
We performed a meta-analysis to synthesise current evidence on amyloid-positron emission tomography (PET) burden and presumed preferential occipital distribution in sporadic cerebral amyloid angiopathy (CAA).. To read the full article, log in using your NHS OpenAthens details.
BPS Blog post. Deep brain stimulation is a medical procedure that involves implanting electrodes permanently into the brain and using them to alter the functioning of specific neural networks. A battery inserted subcutaneously in the chest provides the device with power. One application of the technology is as a treatment for Parkinson’s Disease, a neurodegenerative condition that causes tremors and difficulties moving. While the treatment can bring about an impressive alleviation of symptoms, research suggests that Parkinson’s patients often struggle to adjust psychologically. Now a case study published in the British Journal of Health Psychology has provided some of the first insights into what it’s like for a patient to contemplate undergoing surgery for deep brain stimulation, and then to adjust in the immediate aftermath.
Editorial commentary. Over the last 30 years, disease-modifying drugs (DMDs) that target the immune system either by lymphocytoreduction or by modulating lymphocyte function have become available to treat multiple sclerosis. While all control the episodic acute inflammation of the central nervous system, disease activity ultimately breaks through inevitably resulting in progressive disabilities. It is against this background that the role of autologous haematopoietic stem cell transplantation (aHSCT) has been examined.. To read the full article, log in using your NHS OpenAthens details.
Haematopoietic stem cell transplantation is able to control multiple sclerosis in patients who have failed modern disease modifying drugs
Over the last 30 years, disease-modifying drugs (DMDs) that target the immune system either by lymphocytoreduction or by modulating lymphocyte function have become available to treat multiple sclerosis. While all control the episodic acute inflammation of the central nervous system, disease activity ultimately breaks through inevitably resulting in progressive disabilities. It is against this background that the role of autologous haematopoietic stem cell transplantation (aHSCT) has been examined.. To read the full article, log in using your NHS OpenAthens details.
Advancements in the management of FND emphasise a ‘rule-in’ diagnosis and roles for cognitive behavioural therapy (CBT)1 and physical therapy (PT).2 Neuroimaging studies have also started delineating the neuropathophysiology of FND.3 In the same cohort as this present study, we previously identified that impaired mental health and increased trait anxiety correlated with individual differences in amygdalar volume in patients with FND, while diminished physical functioning was associated with reduced anterior insular volume.4 In FND, the magnitude of adverse life event burden also correlated with decreased insular and hippocampal volumes.5. To read the full article, log in using your NHS OpenAthens details.
Advancements in the management of FND emphasise a ‘rule-in’ diagnosis and roles for cognitive behavioural therapy (CBT)1 and physical therapy (PT).2 Neuroimaging studies have also started delineating the neuropathophysiology of FND.3 In the same cohort as this present study, we previously identified that impaired mental health and increased trait anxiety correlated with individual differences in amygdalar volume in patients with FND, while diminished physical functioning was associated with reduced anterior insular volume.4 In FND, the magnitude of adverse life event burden also correlated with decreased insular and hippocampal volumes.5. To read the full article, log in using your NHS OpenAthens details.