Mitogen-activated protein kinase p38 is a serin/threonine kinase originally isolated from lipopolysaccharide stimulated monocytes. There are 4 isoforms; p38-a activation has been most widely studied for inflammation...
Dr. Noboru Ashida, Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaramachi, Shogoin Sakyo-ku, Kyoto 606-8507, Japan. Voice +81-75-751-3465; fax: +81-75-751-3574; ash@kuhp.kyoto.u.ac.jp.
The anti-inflammatory potential of an oral p38 MAPK inhibitor in humans in vivo suggests that p38 MAPK inhibitors may provide a new therapeutic option in the treatment of inflammatory diseases. Boehringer Ingelheim. 2002 Branger J, et al
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY. Judith Branger, Bernt van den Blink, Sebastiaan Weijer, Abhya Gupta, Sander J.H. van Deventer, C. Erik Hack, Maikel P. Peppelenbosch, and Tom van der Poll
S. Graham, P. Combes, M. Crumiere, K. Klotz, and J. Dickenson. Eur J Pharmacol, 420 (1):
19-26(May 2001)Graham, S Combes, P Crumiere, M Klotz, K N Dickenson, J M Research
Support, Non-U.S. Gov't Netherlands European journal of pharmacology
Eur J Pharmacol. 2001 May 18;420(1):19-26..
J. Humrich, C. Bermel, M. Bunemann, L. Harmark, R. Frost, U. Quitterer, and M. Lohse. J Biol Chem, 280 (20):
20042-50(May 2005)Humrich, Jan Bermel, Christina Bunemann, Moritz Harmark, Linda Frost,
Robert Quitterer, Ursula Lohse, Martin J In Vitro United States The
Journal of biological chemistry J Biol Chem. 2005 May 20;280(20):20042-50.
Epub 2005 Mar 2..
J. Humrich, C. Bermel, T. Grubel, U. Quitterer, and M. Lohse. J Biol Chem, 278 (7):
4474-81(February 2003)Humrich, Jan Bermel, Christina Grubel, Tobias Quitterer, Ursula Lohse,
Martin J United States The Journal of biological chemistry J Biol
Chem. 2003 Feb 14;278(7):4474-81. Epub 2002 Dec 3..
C. Krasel, M. Bunemann, K. Lorenz, and M. Lohse. J Biol Chem, 280 (10):
9528-35(March 2005)Krasel, Cornelius Bunemann, Moritz Lorenz, Kristina Lohse, Martin
J Research Support, Non-U.S. Gov't United States The Journal of biological
chemistry J Biol Chem. 2005 Mar 11;280(10):9528-35. Epub 2005 Jan
5..
C. Krasel, S. Dammeier, R. Winstel, J. Brockmann, H. Mischak, and M. Lohse. J Biol Chem, 276 (3):
1911-5(January 2001)Krasel, C Dammeier, S Winstel, R Brockmann, J Mischak, H Lohse, M
J Research Support, Non-U.S. Gov't United States The Journal of biological
chemistry J Biol Chem. 2001 Jan 19;276(3):1911-5. Epub 2000 Oct 19..
M. Lohse, S. Andexinger, J. Pitcher, S. Trukawinski, J. Codina, J. Faure, M. Caron, and R. Lefkowitz. J Biol Chem, 267 (12):
8558-64(April 1992)Lohse, M J Andexinger, S Pitcher, J Trukawinski, S Codina, J Faure,
J P Caron, M G Lefkowitz, R J DK 19318/DK/NIDDK NIH HHS/United States
HL 16037/HL/NHLBI NIH HHS/United States Research Support, Non-U.S.
Gov't Research Support, U.S. Gov't, P.H.S. United states The Journal
of biological chemistry J Biol Chem. 1992 Apr 25;267(12):8558-64..
M. Lohse, R. Lefkowitz, M. Caron, and J. Benovic. Proc Natl Acad Sci U S A, 86 (9):
3011-5(May 1989)Lohse, M J Lefkowitz, R J Caron, M G Benovic, J L Comparative Study
Research Support, Non-U.S. Gov't United states Proceedings of the
National Academy of Sciences of the United States of America Proc
Natl Acad Sci U S A. 1989 May;86(9):3011-5..
K. Lorenz, M. Lohse, and U. Quitterer. Nature, 426 (6966):
574-9(December 2003)Lorenz, Kristina Lohse, Martin J Quitterer, Ursula Research Support,
Non-U.S. Gov't England Nature Nature. 2003 Dec 4;426(6966):574-9..
K. Lorenz, J. Schmitt, E. Schmitteckert, and M. Lohse. Nat Med, 15 (1):
75-83(January 2009)Lorenz, Kristina Schmitt, Joachim P Schmitteckert, Eva M Lohse, Martin
J Research Support, Non-U.S. Gov't United States Nature medicine
Nat Med. 2009 Jan;15(1):75-83. Epub 2008 Dec 7..
G. Mayer, B. Wulffen, C. Huber, J. Brockmann, B. Flicke, L. Neumann, D. Hafenbradl, B. Klebl, M. Lohse, C. Krasel and 1 other author(s). RNA, 14 (3):
524-34(March 2008)Mayer, Gunter Wulffen, Bernhard Huber, Christian Brockmann, Jorg
Flicke, Birgit Neumann, Lars Hafenbradl, Doris Klebl, Bert M Lohse,
Martin J Krasel, Cornelius Blind, Michael In Vitro Research Support,
Non-U.S. Gov't United States RNA (New York, N.Y.) RNA. 2008 Mar;14(3):524-34.
Epub 2008 Jan 29..
S. Merighi, P. Mirandola, D. Milani, K. Varani, S. Gessi, K. Klotz, E. Leung, P. Baraldi, and P. Borea. J Invest Dermatol, 119 (4):
923-33(October 2002)Merighi, Stefania Mirandola, Prisco Milani, Daniela Varani, Katia
Gessi, Stefania Klotz, Karl-Norbert Leung, Edward Baraldi, Pier Giovanni
Borea, Pier Andrea United States The Journal of investigative dermatology
J Invest Dermatol. 2002 Oct;119(4):923-33..