Aging may be an intrinsic factor in the development of anemia, possibly through the age-related dysregulation of certain proinflammatory cytokines such as interleukin-6 (IL-6)...Increased IL-6 and other proinflammatory cytokines directly inhibit erythropo
Mind-boggling networks of cytokines and transcription factors have been invoked to explain the anemia of inflammation. Does it really have to be so complicated? Elevated hepcidin; defensive sequestering of serum ferritin (iron); direct cytokine disruption
commonly observed in patients with chronic infections, malignancy, trauma, and inflammatory disorders...inflammatory cytokine IL-6 induces production of hepcidin, an iron-regulatory hormone that may be responsible...