Weak willpower & procrastination caused by dopamine hypofunction is one of those neurological deficiencies which effort alone can't overcome. Happily, in our transhuman paradise, even the most lethargic spirit can move mountains.
Accounts of use for depression, ADD/ADHD, fibromyalgia, chronic fatigue (off-label). Metabolic precursor to modafinil; takes 1 hr to kick in, hard on liver. Not "controlled" like modafinil/Provigil.
Unlike conventional stimulants, no anxiety, agitation and insomnia; selectively stimulates brain's adrenergic receptors for norepinephrine (noradrenaline), a neurotransmitter linked to alertness, learning, and memory.
Armodafinil (Nuvigil®) is an eugeroic drug made by Cephalon, FDA-approved 6/15/2007. Clinical trials for its use in bipolar disorder, cognition in schizophrenia, excessive fatigue in Parkinson's & cancer, begin. Patent expires 2023.
A single protein in the brain influences arousal of despair, according to new study in mice. Brain biopsies revealed that mice trying hardest to escape shocks had highest levels of delta-FosB - which may also help humans avoid hopelessness & helplessness.
One of the characteristic manifestations of prolonged stress is decreased performance in tasks that require attention, including the ability to shift focus as well as to learn and unlearn information. Anxiety and depression can make a person feel as if he
This CURRENTLY ENROLLING study will test whether a single dose of ketamine - a drug that blocks a brain receptor called NMDA - can cause a rapid (next day) antidepressant effect in patients with major depression. Several medications are effective for trea
depressed individuals actually have more realistic perceptions of their own image, importance, and abilities than the average person. While it’s still generally accepted that depressed people can be negatively biased in their interpretation of events an
Modafinil induces wakefulness, but its dopamine-releasing action in the nucleus accumbens is weak and dose-dependent; no likelihood of euphoric response ('abuse potential').