Aging may be an intrinsic factor in the development of anemia, possibly through the age-related dysregulation of certain proinflammatory cytokines such as interleukin-6 (IL-6)...Increased IL-6 and other proinflammatory cytokines directly inhibit erythropo
commonly observed in patients with chronic infections, malignancy, trauma, and inflammatory disorders...inflammatory cytokine IL-6 induces production of hepcidin, an iron-regulatory hormone that may be responsible...
Because cytokines share many properties with hormones and growth factors, the distinction between these three classes of mediators is becoming blurred. Any classification of cytokines represents a somewhat arbitrary arrangement on the part of the individu
The same cytokine may have different effects in different circumstances. (This is called ' pleotropy '). See below chart for key functions of significant cytokines.
PERSISTENT LOW-GRADE INFLAMMATION, as indicated by higher circulating levels of inflammatory mediators such as C-reactive protein, interleukin-6 and tumour necrosis factor-, is a strong risk factor for several chronic diseases. There are data indicating t