Purpose: The scope and significance of human anti-animal antibody interference in immunological assays is reviewed with an emphasis on human anti-animal immunoglobulins, particularly human anti-mouse antibodies (HAMAs). Issues: Anti-animal antibodies (IgG, IgA, IgM, IgE class, anti-isotype, and anti-idiotype specificity) arise as a result of iatrogenic and noniatrogenic causes and include human anti-mouse, -rabbit, -goat, -sheep, -cow, -pig, -rat, and -horse antibodies and antibodies with mixed specificity. Circulating antibodies can reach gram per liter concentrations and may persist for years. Prevalence estimates for anti-animal antibodies in the general population vary widely and range from <1% to 80%. Human anti-animal antibodies cause interferences in immunological assays. The most common human anti-animal antibody interferent is HAMA, which causes both positive and negative interferences in two-site mouse monoclonal antibody-based assays. Strategies to prevent the development of
%0 Journal Article
%1 Kricka.1999
%A Kricka, L. J.
%D 1999
%J Clin.Chem.
%K Animals Antibodies Antibody Body False Fluids Human Humans Immunoassay Laboratories Mice Monoclonal Negative Population Positive RANGE Reactions Specificity analysis immunology methods pathology response standards therapy
%N 7
%P 942-956
%T Human anti-animal antibody interferences in immunological assays
%U PM:10388468
%V 45
%X Purpose: The scope and significance of human anti-animal antibody interference in immunological assays is reviewed with an emphasis on human anti-animal immunoglobulins, particularly human anti-mouse antibodies (HAMAs). Issues: Anti-animal antibodies (IgG, IgA, IgM, IgE class, anti-isotype, and anti-idiotype specificity) arise as a result of iatrogenic and noniatrogenic causes and include human anti-mouse, -rabbit, -goat, -sheep, -cow, -pig, -rat, and -horse antibodies and antibodies with mixed specificity. Circulating antibodies can reach gram per liter concentrations and may persist for years. Prevalence estimates for anti-animal antibodies in the general population vary widely and range from <1% to 80%. Human anti-animal antibodies cause interferences in immunological assays. The most common human anti-animal antibody interferent is HAMA, which causes both positive and negative interferences in two-site mouse monoclonal antibody-based assays. Strategies to prevent the development of
@article{Kricka.1999,
abstract = {Purpose: The scope and significance of human anti-animal antibody interference in immunological assays is reviewed with an emphasis on human anti-animal immunoglobulins, particularly human anti-mouse antibodies (HAMAs). Issues: Anti-animal antibodies (IgG, IgA, IgM, IgE class, anti-isotype, and anti-idiotype specificity) arise as a result of iatrogenic and noniatrogenic causes and include human anti-mouse, -rabbit, -goat, -sheep, -cow, -pig, -rat, and -horse antibodies and antibodies with mixed specificity. Circulating antibodies can reach gram per liter concentrations and may persist for years. Prevalence estimates for anti-animal antibodies in the general population vary widely and range from <1% to 80%. Human anti-animal antibodies cause interferences in immunological assays. The most common human anti-animal antibody interferent is HAMA, which causes both positive and negative interferences in two-site mouse monoclonal antibody-based assays. Strategies to prevent the development of},
added-at = {2010-02-05T11:28:39.000+0100},
author = {Kricka, L. J.},
biburl = {https://www.bibsonomy.org/bibtex/23291ad06c7f9e078e0da4277d67745c2/kanefendt},
interhash = {421c517d07206f204efc577fd5b3509b},
intrahash = {3291ad06c7f9e078e0da4277d67745c2},
journal = {Clin.Chem.},
keywords = {Animals Antibodies Antibody Body False Fluids Human Humans Immunoassay Laboratories Mice Monoclonal Negative Population Positive RANGE Reactions Specificity analysis immunology methods pathology response standards therapy},
number = 7,
pages = {942-956},
timestamp = {2010-02-05T11:28:45.000+0100},
title = {Human anti-animal antibody interferences in immunological assays},
url = {PM:10388468},
volume = 45,
year = 1999
}