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A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists
L. Yan, D. C. Bertarelli, A. M. Hayallah, H. Meyer, K. N. Klotz, and C. E. Muller. J Med Chem 49(14):4384-91 (July 2006)Yan, Luo Bertarelli, Daniela C G Hayallah, Alaa M Meyer, Heiko Klotz, Karl-Norbert Muller, Christa E In Vitro Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2006 Jul 13;4914:4384-91..
L. Yan, D. C. Bertarelli, A. M. Hayallah, H. Meyer, K. N. Klotz, and C. E. Muller. J Med Chem 49(14):4384-91 (July 2006)Yan, Luo Bertarelli, Daniela C G Hayallah, Alaa M Meyer, Heiko Klotz, Karl-Norbert Muller, Christa E In Vitro Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2006 Jul 13;4914:4384-91..
2 years and 5 months ago
by pharmawuerz
1
& A2B/*antagonists Adenosine Animals Arylsulfonates/*chemistry Assay Brain/metabolism CHO Cricetinae Cricetulus Humans Proteins/antagonists Radioligand Rats Recombinant Relationship Structure-Activity Sulfonamides/*chemical Xanthines/*chemical inhibitors synthesis/chemistry/pharmacology Receptor Cell
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Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido1,2,3-cdpurinediones
S. Weyler, F. Fulle, M. Diekmann, B. Schumacher, S. Hinz, K. N. Klotz, and C. E. Muller. ChemMedChem 1(8):891-902 (August 2006)Weyler, Stefanie Fulle, Friederike Diekmann, Martina Schumacher, Britta Hinz, Sonja Klotz, Karl-Norbert Muller, Christa E Research Support, Non-U.S. Gov't Germany ChemMedChem ChemMedChem. 2006 Aug;18:891-902..
S. Weyler, F. Fulle, M. Diekmann, B. Schumacher, S. Hinz, K. N. Klotz, and C. E. Muller. ChemMedChem 1(8):891-902 (August 2006)Weyler, Stefanie Fulle, Friederike Diekmann, Martina Schumacher, Britta Hinz, Sonja Klotz, Karl-Norbert Muller, Christa E Research Support, Non-U.S. Gov't Germany ChemMedChem ChemMedChem. 2006 Aug;18:891-902..
2 years and 5 months ago
by pharmawuerz
2
& A1/*antagonists Adamantane/*analogs Adenosine Animals Cultured Humans Phosphates/chemistry Prodrugs/chemistry/*pharmacology Rats Relationship Solubility Structure-Activity Water/chemistry Xanthine/*chemistry Xanthines/chemistry/*pharmacology derivatives/chemistry/pharmacology inhibitors Receptor Cell
(0)
URLDOITeX
N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor
R. Volpini, D. Dal Ben, C. Lambertucci, S. Taffi, S. Vittori, K. N. Klotz, and G. Cristalli. J Med Chem 50(6):1222-30 (March 2007)Volpini, Rosaria Dal Ben, Diego Lambertucci, Catia Taffi, Sara Vittori, Sauro Klotz, Karl-Norbert Cristalli, Gloria Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2007 Mar 22;506:1222-30. Epub 2007 Feb 20..
R. Volpini, D. Dal Ben, C. Lambertucci, S. Taffi, S. Vittori, K. N. Klotz, and G. Cristalli. J Med Chem 50(6):1222-30 (March 2007)Volpini, Rosaria Dal Ben, Diego Lambertucci, Catia Taffi, Sara Vittori, Sauro Klotz, Karl-Norbert Cristalli, Gloria Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2007 Mar 22;506:1222-30. Epub 2007 Feb 20..
2 years and 5 months ago
by pharmawuerz
2
& *Models, A3/*agonists AMP/biosynthesis Acid Adenosine Adenosine/*analogs Alkynes/*chemical Amino Animals Assay CHO Cricetinae Cricetulus Cyclic Homology, Humans Ligands Molecular Proteins/agonists Radioligand Recombinant Relationship Rhodopsin/chemistry Sequence Structure-Activity derivatives/*chemical synthesis/chemistry/pharmacology Receptor Cell
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URLDOITeX
Medicinal chemistry and pharmacology of A2B adenosine receptors
R. Volpini, S. Costanzi, S. Vittori, G. Cristalli, and K. N. Klotz. Curr Top Med Chem 3(4):427-43 (2003)Volpini, Rosaria Costanzi, Stefano Vittori, Sauro Cristalli, Gloria Klotz, Karl-Norbert Research Support, Non-U.S. Gov't Netherlands Current topics in medicinal chemistry Curr Top Med Chem. 2003;34:427-43..
R. Volpini, S. Costanzi, S. Vittori, G. Cristalli, and K. N. Klotz. Curr Top Med Chem 3(4):427-43 (2003)Volpini, Rosaria Costanzi, Stefano Vittori, Sauro Cristalli, Gloria Klotz, Karl-Norbert Research Support, Non-U.S. Gov't Netherlands Current topics in medicinal chemistry Curr Top Med Chem. 2003;34:427-43..
2 years and 5 months ago
by pharmawuerz
2
& *Drug *Receptors, A2B Adenine/analogs Adenosine Adenosine/analogs Animals Data Design Homology Humans Molecular P1/agonists/antagonists Purinergic Relationship Sequence Structure-Activity Xanthines/chemistry/*pharmacology derivatives/*pharmacology inhibitors/chemistry Receptor
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URLDOITeX
N6-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A3 receptor and a starting point for searching A2B ligands
R. Volpini, S. Costanzi, C. Lambertucci, S. Taffi, S. Vittori, K. N. Klotz, and G. Cristalli. J Med Chem 45(15):3271-9 (July 2002)Volpini, Rosaria Costanzi, Stefano Lambertucci, Catia Taffi, Sara Vittori, Sauro Klotz, Karl-Norbert Cristalli, Gloria Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2002 Jul 18;4515:3271-9..
R. Volpini, S. Costanzi, C. Lambertucci, S. Taffi, S. Vittori, K. N. Klotz, and G. Cristalli. J Med Chem 45(15):3271-9 (July 2002)Volpini, Rosaria Costanzi, Stefano Lambertucci, Catia Taffi, Sara Vittori, Sauro Klotz, Karl-Norbert Cristalli, Gloria Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2002 Jul 18;4515:3271-9..
2 years and 5 months ago
by pharmawuerz
2
& A2A A2B A3 Adenosine Adenosine/*analogs Adenylate Alkynes/*chemical Animals CHO Cricetinae Cyclase/metabolism Humans Ligands Magnetic P1/*agonists/metabolism Proteins/metabolism Purinergic Recombinant Relationship Resonance Spectroscopy Stereoisomerism Structure-Activity derivatives/*chemical synthesis/chemistry/pharmacology Receptor Cell
(0)
URLDOITeX
Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A2A-selective adenosine receptor antagonists
R. Sauer, J. Maurinsh, U. Reith, F. Fulle, K. N. Klotz, and C. E. Muller. J Med Chem 43(3):440-8 (February 2000)Sauer, R Maurinsh, J Reith, U Fulle, F Klotz, K N Muller, C E In Vitro Research Support, Non-U.S. Gov't United states Journal of medicinal chemistry J Med Chem. 2000 Feb 10;433:440-8..
R. Sauer, J. Maurinsh, U. Reith, F. Fulle, K. N. Klotz, and C. E. Muller. J Med Chem 43(3):440-8 (February 2000)Sauer, R Maurinsh, J Reith, U Fulle, F Klotz, K N Muller, C E In Vitro Research Support, Non-U.S. Gov't United states Journal of medicinal chemistry J Med Chem. 2000 Feb 10;433:440-8..
2 years and 5 months ago
by pharmawuerz
1
& A2A Adenosine Animals Assay CHO Caudate Cerebral Corpus Cortex/metabolism Cricetinae Humans Nucleus/metabolism P1/*antagonists Prodrugs/*chemical Proteins/antagonists Purinergic Radioligand Rats Recombinant Relationship Solubility Striatum/metabolism Structure-Activity Xanthines/*chemical inhibitors synthesis/chemistry/metabolism/pharmacology synthesis/chemistry/pharmacology Receptor Cell
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URLDOITeX
Synthesis, biological studies and molecular modeling investigation of 1,3-dimethyl-2,4-dioxo-6-methyl-8-substituted 1,2,3,4-tetrahydro 1,2,4-triazolo 3,4-f-purines as potential adenosine receptor antagonists
G. Pastorin, C. Bolcato, B. Cacciari, S. Kachler, K. N. Klotz, C. Montopoli, S. Moro, and G. Spalluto. Farmaco 60(4):299-306 (April 2005)Pastorin, Giorgia Bolcato, Chiara Cacciari, Barbara Kachler, Sonja Klotz, Karl-Norbert Montopoli, Christian Moro, Stefano Spalluto, Giampiero Research Support, Non-U.S. Gov't Italy Farmaco Societa chimica italiana : 1989 Farmaco. 2005 Apr;604:299-306..
G. Pastorin, C. Bolcato, B. Cacciari, S. Kachler, K. N. Klotz, C. Montopoli, S. Moro, and G. Spalluto. Farmaco 60(4):299-306 (April 2005)Pastorin, Giorgia Bolcato, Chiara Cacciari, Barbara Kachler, Sonja Klotz, Karl-Norbert Montopoli, Christian Moro, Stefano Spalluto, Giampiero Research Support, Non-U.S. Gov't Italy Farmaco Societa chimica italiana : 1989 Farmaco. 2005 Apr;604:299-306..
2 years and 5 months ago
by pharmawuerz
2
& Adenylate Animals Binding Cell Cricetinae Cricetulus Cyclase/metabolism Cyclization Line Membrane/metabolism Models, Molecular P1/*antagonists Protein Purinergic Purines/*chemical Rats Relationship Sites Structure Structure-Activity Triazoles/*chemical inhibitors synthesis/chemistry/pharmacology Receptor
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URLDOITeX
Synthesis, biological and modeling studies of 1,3-di-n-propyl-2,4-dioxo-6-methyl-8-substituted 1,2,3,4-tetrahydro 1,2,4-triazolo 3,4-f-purines as adenosine receptor antagonists
G. Pastorin, C. Bolcato, B. Cacciari, S. Kachler, K. N. Klotz, C. Montopoli, S. Moro, and G. Spalluto. Farmaco 60(8):643-51 (August 2005)Pastorin, G Bolcato, C Cacciari, B Kachler, S Klotz, K-N Montopoli, C Moro, S Spalluto, G Research Support, Non-U.S. Gov't France Farmaco Societa chimica italiana : 1989 Farmaco. 2005 Aug;608:643-51..
G. Pastorin, C. Bolcato, B. Cacciari, S. Kachler, K. N. Klotz, C. Montopoli, S. Moro, and G. Spalluto. Farmaco 60(8):643-51 (August 2005)Pastorin, G Bolcato, C Cacciari, B Kachler, S Klotz, K-N Montopoli, C Moro, S Spalluto, G Research Support, Non-U.S. Gov't France Farmaco Societa chimica italiana : 1989 Farmaco. 2005 Aug;608:643-51..
2 years and 5 months ago
by pharmawuerz
2
& *Drug *Purines/chemical A1/antagonists A2A/antagonists A2B/antagonists A3/*antagonists Adenosine Binding Conformation Design Drug Evaluation, Humans Models, Molecular Preclinical Protein Rats Relationship Secondary Sites Structure Structure, Structure-Activity inhibitors synthesis/chemistry/pharmacology Receptor
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Molecular basis of partial agonism at the neurotransmitter alpha2A-adrenergic receptor and Gi-protein heterotrimer
V. O. Nikolaev, C. Hoffmann, M. Bunemann, M. J. Lohse, and J. P. Vilardaga. J Biol Chem 281(34):24506-11 (August 2006)Nikolaev, Viacheslav O Hoffmann, Carsten Bunemann, Moritz Lohse, Martin J Vilardaga, Jean-Pierre Research Support, Non-U.S. Gov't United States The Journal of biological chemistry J Biol Chem. 2006 Aug 25;28134:24506-11. Epub 2006 Jun 20..
V. O. Nikolaev, C. Hoffmann, M. Bunemann, M. J. Lohse, and J. P. Vilardaga. J Biol Chem 281(34):24506-11 (August 2006)Nikolaev, Viacheslav O Hoffmann, Carsten Bunemann, Moritz Lohse, Martin J Vilardaga, Jean-Pierre Research Support, Non-U.S. Gov't United States The Journal of biological chemistry J Biol Chem. 2006 Aug 25;28134:24506-11. Epub 2006 Jun 20..
2 years and 5 months ago
by pharmawuerz
2
Animals Conformation Fusion GTP-Binding Gi-Go/*agonists/*chemistry/genetics Humans Kinetics Ligands Mice Protein Proteins Recombinant Relationship Signal Structure-Activity Subunits, Transduction alpha alpha-2/*agonists/*chemistry/genetics Receptor Adrenergic
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8-Sulfostyrylxanthines: water-soluble A2A-selective adenosine receptor antagonists
C. E. Muller, J. Sandoval-Ramirez, U. Schobert, U. Geis, W. Frobenius, and K. N. Klotz. Bioorg Med Chem 6(6):707-19 (June 1998)Muller, C E Sandoval-Ramirez, J Schobert, U Geis, U Frobenius, W Klotz, K N England Bioorganic \& medicinal chemistry Bioorg Med Chem. 1998 Jun;66:707-19..
C. E. Muller, J. Sandoval-Ramirez, U. Schobert, U. Geis, W. Frobenius, and K. N. Klotz. Bioorg Med Chem 6(6):707-19 (June 1998)Muller, C E Sandoval-Ramirez, J Schobert, U Geis, U Frobenius, W Klotz, K N England Bioorganic \& medicinal chemistry Bioorg Med Chem. 1998 Jun;66:707-19..
2 years and 5 months ago
by pharmawuerz
2
& A2A Acids/*chemical Adenosine Animals Arylsulfonic Assay CHO Central Cerebral Concentration Cortex/metabolism Cricetinae Humans Hydrogen-Ion Magnetic Nervous P1/*antagonists Proteins/antagonists Purinergic Radioligand Rats Recombinant Relationship Resonance Solubility Spectroscopy Stimulants/*chemical Structure-Activity Styrenes/*chemical System Xanthines/*chemical inhibitors/biosynthesis synthesis/chemistry/metabolism/pharmacology Receptor Cell
(0)
URLDOITeX
The application of a 3D-QSAR autoMEP/PLS approach as an efficient pharmacodynamic-driven filtering method for small-sized virtual library: application to a lead optimization of a human A3 adenosine receptor antagonist
S. Moro, M. Bacilieri, B. Cacciari, C. Bolcato, C. Cusan, G. Pastorin, K. N. Klotz, and G. Spalluto. Bioorg Med Chem 14(14):4923-32 (July 2006)Moro, Stefano Bacilieri, Magdalena Cacciari, Barbara Bolcato, Chiara Cusan, Claudia Pastorin, Giorgia Klotz, Karl-Norbert Spalluto, Giampiero In Vitro Research Support, Non-U.S. Gov't England Bioorganic \& medicinal chemistry Bioorg Med Chem. 2006 Jul 15;1414:4923-32. Epub 2006 Mar 29..
S. Moro, M. Bacilieri, B. Cacciari, C. Bolcato, C. Cusan, G. Pastorin, K. N. Klotz, and G. Spalluto. Bioorg Med Chem 14(14):4923-32 (July 2006)Moro, Stefano Bacilieri, Magdalena Cacciari, Barbara Bolcato, Chiara Cusan, Claudia Pastorin, Giorgia Klotz, Karl-Norbert Spalluto, Giampiero In Vitro Research Support, Non-U.S. Gov't England Bioorganic \& medicinal chemistry Bioorg Med Chem. 2006 Jul 15;1414:4923-32. Epub 2006 Mar 29..
2 years and 5 months ago
by pharmawuerz
2
& A3/*antagonists Adenosine Analysis Binding Chemistry Combinatorial Conformation Design Drug Electricity Humans Interface Least-Squares Models, Molecular Protein Pyrimidines/chemical Quantitative Relationship Sites Static Structure-Activity Techniques User-Computer inhibitors/chemistry synthesis/chemistry/pharmacology Receptor
(0)
URLDOITeX
Combining selectivity and affinity predictions using an integrated Support Vector Machine SVM approach: An alternative tool to discriminate between the human adenosine A2A and A3 receptor pyrazolo-triazolo-pyrimidine antagonists binding sites
L. Michielan, C. Bolcato, S. Federico, B. Cacciari, M. Bacilieri, K. N. Klotz, S. Kachler, G. Pastorin, R. Cardin, A. Sperduti, G. Spalluto, and S. Moro. Bioorg Med Chem 17(14):5259-74 (July 2009)Michielan, Lisa Bolcato, Chiara Federico, Stephanie Cacciari, Barbara Bacilieri, Magdalena Klotz, Karl-Norbert Kachler, Sonja Pastorin, Giorgia Cardin, Riccardo Sperduti, Alessandro Spalluto, Giampiero Moro, Stefano Research Support, Non-U.S. Gov't England Bioorganic \& medicinal chemistry Bioorg Med Chem. 2009 Jul 15;1714:5259-74. Epub 2009 May 21..
L. Michielan, C. Bolcato, S. Federico, B. Cacciari, M. Bacilieri, K. N. Klotz, S. Kachler, G. Pastorin, R. Cardin, A. Sperduti, G. Spalluto, and S. Moro. Bioorg Med Chem 17(14):5259-74 (July 2009)Michielan, Lisa Bolcato, Chiara Federico, Stephanie Cacciari, Barbara Bacilieri, Magdalena Klotz, Karl-Norbert Kachler, Sonja Pastorin, Giorgia Cardin, Riccardo Sperduti, Alessandro Spalluto, Giampiero Moro, Stefano Research Support, Non-U.S. Gov't England Bioorganic \& medicinal chemistry Bioorg Med Chem. 2009 Jul 15;1714:5259-74. Epub 2009 May 21..
2 years and 5 months ago
by pharmawuerz
2
& *Artificial A2A/*antagonists A3/*antagonists Adenosine Binding Chemical Discovery Drug Electricity Humans Intelligence Models, Protein Pyrazoles/chemical Pyrimidines/chemical Relationship Sites Static Structure-Activity Triazoles/chemical inhibitors/chemistry/*metabolism synthesis/*chemistry/*pharmacology synthesis/chemistry/pharmacology Receptor
(0)
URLDOITeX
Linear and nonlinear 3D-QSAR approaches in tandem with ligand-based homology modeling as a computational strategy to depict the pyrazolo-triazolo-pyrimidine antagonists binding site of the human adenosine A2A receptor
L. Michielan, M. Bacilieri, A. Schiesaro, C. Bolcato, G. Pastorin, G. Spalluto, B. Cacciari, K. N. Klotz, C. Kaseda, and S. Moro. J Chem Inf Model 48(2):350-63 (February 2008)Michielan, Lisa Bacilieri, Magdalena Schiesaro, Andrea Bolcato, Chiara Pastorin, Giorgia Spalluto, Giampiero Cacciari, Barbara Klotz, Karl Norbet Kaseda, Chosei Moro, Stefano Research Support, Non-U.S. Gov't United States Journal of chemical information and modeling J Chem Inf Model. 2008 Feb;482:350-63. Epub 2008 Jan 24..
L. Michielan, M. Bacilieri, A. Schiesaro, C. Bolcato, G. Pastorin, G. Spalluto, B. Cacciari, K. N. Klotz, C. Kaseda, and S. Moro. J Chem Inf Model 48(2):350-63 (February 2008)Michielan, Lisa Bacilieri, Magdalena Schiesaro, Andrea Bolcato, Chiara Pastorin, Giorgia Spalluto, Giampiero Cacciari, Barbara Klotz, Karl Norbet Kaseda, Chosei Moro, Stefano Research Support, Non-U.S. Gov't United States Journal of chemical information and modeling J Chem Inf Model. 2008 Feb;482:350-63. Epub 2008 Jan 24..
2 years and 5 months ago
by pharmawuerz
2
& *Models, *Quantitative *Sequence A2A/antagonists Acid Adenosine Amino Binding Homology, Humans Ligands Molecular Pyrazoles Pyrimidines Relationship Sites Structure-Activity Triazoles inhibitors/*chemistry Receptor
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Barbiturates are selective antagonists at A1 adenosine receptors
M. J. Lohse, K. N. Klotz, K. H. Jakobs, and U. Schwabe. J Neurochem 45(6):1761-70 (December 1985)Lohse, M J Klotz, K N Jakobs, K H Schwabe, U Research Support, Non-U.S. Gov't United states Journal of neurochemistry J Neurochem. 1985 Dec;456:1761-70..
M. J. Lohse, K. N. Klotz, K. H. Jakobs, and U. Schwabe. J Neurochem 45(6):1761-70 (December 1985)Lohse, M J Klotz, K N Jakobs, K H Schwabe, U Research Support, Non-U.S. Gov't United states Journal of neurochemistry J Neurochem. 1985 Dec;456:1761-70..
2 years and 5 months ago
by pharmawuerz
2
& Adenylate Animals Barbiturates/*pharmacology Cell Corpus Cyclase/metabolism GABA-A/metabolism Humans Line Male Neuroblastoma/enzymology/metabolism Phenobarbital/analogs Phenylisopropyladenosine/metabolism Purinergic Rats Relationship Strains Striatum/enzymology/metabolism Structure-Activity Surface/*antagonists derivatives/pharmacology inhibitors/metabolism Receptor Mice
(0)
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New directions in pharmacology
M. J. Lohse. Lancet (December 1999)Lohse, M J England Lancet Lancet. 1999 Dec;354 Suppl:SIV52..
M. J. Lohse. Lancet (December 1999)Lohse, M J England Lancet Lancet. 1999 Dec;354 Suppl:SIV52..
2 years and 5 months ago
by pharmawuerz
2
*Pharmacology, Biology Clinical/trends Humans Molecular Relationship Structure-Activity
(0)
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8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands
C. Lambertucci, I. Antonini, M. Buccioni, D. Dal Ben, D. D. Kachare, R. Volpini, K. N. Klotz, and G. Cristalli. Bioorg Med Chem 17(7):2812-22 (April 2009)Lambertucci, Catia Antonini, Ippolito Buccioni, Michela Dal Ben, Diego Kachare, Dhuldeo D Volpini, Rosaria Klotz, Karl-Norbert Cristalli, Gloria Research Support, Non-U.S. Gov't England Bioorganic \& medicinal chemistry Bioorg Med Chem. 2009 Apr 1;177:2812-22. Epub 2009 Feb 23..
C. Lambertucci, I. Antonini, M. Buccioni, D. Dal Ben, D. D. Kachare, R. Volpini, K. N. Klotz, and G. Cristalli. Bioorg Med Chem 17(7):2812-22 (April 2009)Lambertucci, Catia Antonini, Ippolito Buccioni, Michela Dal Ben, Diego Kachare, Dhuldeo D Volpini, Rosaria Klotz, Karl-Norbert Cristalli, Gloria Research Support, Non-U.S. Gov't England Bioorganic \& medicinal chemistry Bioorg Med Chem. 2009 Apr 1;177:2812-22. Epub 2009 Feb 23..
2 years and 5 months ago
by pharmawuerz
2
& A2A/*antagonists A2B/*antagonists Adenine/*analogs Adenosine Animals Binding CHO Computer Cricetinae Cricetulus Humans Models, Molecular Relationship Simulation Sites Structure-Activity Transfection derivatives/chemistry/pharmacology inhibitors/metabolism Receptor Cell
(0)
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9-Ethyladenine derivatives as adenosine receptor antagonists: 2- and 8-substitution results in distinct selectivities
K. N. Klotz, S. Kachler, C. Lambertucci, S. Vittori, R. Volpini, and G. Cristalli. Naunyn Schmiedebergs Arch Pharmacol 367(6):629-34 (June 2003)Klotz, Karl-Norbert Kachler, Sonja Lambertucci, Catia Vittori, Sauro Volpini, Rosaria Cristalli, Gloria Research Support, Non-U.S. Gov't Germany Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;3676:629-34. Epub 2003 May 7..
K. N. Klotz, S. Kachler, C. Lambertucci, S. Vittori, R. Volpini, and G. Cristalli. Naunyn Schmiedebergs Arch Pharmacol 367(6):629-34 (June 2003)Klotz, Karl-Norbert Kachler, Sonja Lambertucci, Catia Vittori, Sauro Volpini, Rosaria Cristalli, Gloria Research Support, Non-U.S. Gov't Germany Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;3676:629-34. Epub 2003 May 7..
2 years and 5 months ago
by pharmawuerz
2
& Adenine/*analogs Animals CHO Cricetinae Humans P1/*antagonists Purinergic Relationship Structure-Activity derivatives/*chemistry/*pharmacology inhibitors/chemistry/physiology Receptor Cell
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URLDOITeX
Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells
K. N. Klotz, J. Hessling, J. Hegler, C. Owman, B. Kull, B. B. Fredholm, and M. J. Lohse. Naunyn Schmiedebergs Arch Pharmacol 357(1):1-9 (January 1998)Klotz, K N Hessling, J Hegler, J Owman, C Kull, B Fredholm, B B Lohse, M J Comparative Study Research Support, Non-U.S. Gov't Germany Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;3571:1-9..
K. N. Klotz, J. Hessling, J. Hegler, C. Owman, B. Kull, B. B. Fredholm, and M. J. Lohse. Naunyn Schmiedebergs Arch Pharmacol 357(1):1-9 (January 1998)Klotz, K N Hessling, J Hegler, J Owman, C Kull, B Fredholm, B B Lohse, M J Comparative Study Research Support, Non-U.S. Gov't Germany Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;3571:1-9..
2 years and 5 months ago
by pharmawuerz
2
& Adenosine-5'-(N-ethylcarboxamide)/pharmacology Adenosine/analogs Animals Base Binding, CHO Cells/*metabolism Competitive Composition Cricetinae Cyclase/metabolism Guanylate Humans P1/biosynthesis/*drug Phenethylamines/pharmacology Phenylisopropyladenosine/metabolism Purinergic Relationship Stereoisomerism Structure-Activity Transfection Xanthines/pharmacology derivatives/pharmacology effects/genetics Receptor
(0)
URLDOITeX
Adenosine receptors and their ligands
K. N. Klotz. Naunyn Schmiedebergs Arch Pharmacol 362(4-5):382-91 (November 2000)Klotz, K N Research Support, Non-U.S. Gov't Review Germany Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;3624-5:382-91..
K. N. Klotz. Naunyn Schmiedebergs Arch Pharmacol 362(4-5):382-91 (November 2000)Klotz, K N Research Support, Non-U.S. Gov't Review Germany Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;3624-5:382-91..
2 years and 5 months ago
by pharmawuerz
2
Animals Assay Humans Ligands P1/analysis/*drug Purinergic Radioligand Relationship Structure-Activity Xanthine/pharmacology effects/physiology Receptor
(0)
URLDOITeX
7-Deazaadenines bearing polar substituents: structure-activity relationships of new A1 and A3 adenosine receptor antagonists
S. Hess, C. E. Muller, W. Frobenius, U. Reith, K. N. Klotz, and K. Eger. J Med Chem 43(24):4636-46 (November 2000)Hess, S Muller, C E Frobenius, W Reith, U Klotz, K N Eger, K In Vitro Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2000 Nov 30;4324:4636-46..
S. Hess, C. E. Muller, W. Frobenius, U. Reith, K. N. Klotz, and K. Eger. J Med Chem 43(24):4636-46 (November 2000)Hess, S Muller, C E Frobenius, W Reith, U Klotz, K N Eger, K In Vitro Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2000 Nov 30;4324:4636-46..
2 years and 5 months ago
by pharmawuerz
2
& A3 Adenine/*chemistry Adenosine Animals Assay CHO Cerebral Corpus Cortex/metabolism Cricetinae Humans Indoles/*chemical P1/*antagonists Proteins/metabolism Purinergic Pyrimidines/*chemical Radioligand Rats Recombinant Relationship Solubility Striatum/metabolism Structure-Activity Water inhibitors/metabolism synthesis/chemistry/metabolism/pharmacology Receptor Cell
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URLDOITeX
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