Vascular endothelial growth factor receptor 3 (VEGFR-3) binds VEGF-C and VEGF-D and is essential for the development of the lymphatic vasculature. Experimental tumors that overexpress VEGFR-3 ligands induce lymphatic vessel sprouting and enlargement and show enhanced metastasis to regional lymph nodes and beyond, whereas a soluble form of VEGFR-3 that blocks receptor signaling inhibits these changes and metastasis. Because VEGFR-3 is also essential for the early blood vessel development in embryos and is up-regulated in tumor angiogenesis, we wanted to determine if an antibody targeting the receptor that interferes with VEGFR-3 ligand binding can inhibit primary tumor growth. Our results show that antibody interference with VEGFR-3 function can inhibit the growth of several human tumor xenografts in immunocompromised mice. Immunohistochemical analysis showed that the blood vessel density of anti-VEGFR-3-treated tumors was significantly decreased and hypoxic and necrotic tumor tissue wa
%0 Journal Article
%1 Laakkonen.2007
%A Laakkonen, P.
%A Waltari, M.
%A Holopainen, T.
%A Takahashi, T.
%A Pytowski, B.
%A Steiner, P.
%A Hicklin, D.
%A Persaud, K.
%A Tonra, J. R.
%A Witte, L.
%A Alitalo, K.
%D 2007
%J Cancer Res.
%K & Animals Antibodies Antitumor Assays BALB Binding C Cell D Endothelial Factor Growth Human Humans Immunohistochemistry Inbred Ligands Mice Model Monoclonal Neoplasms Neovascularization Nude Pathologic Processes Receptor-3 Research Vascular Xenograft analysis antagonists blood immunology inhibitors metabolism pharmacology supply therapy
%N 2
%P 593-599
%T Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth
%U PM:17234768
%V 67
%X Vascular endothelial growth factor receptor 3 (VEGFR-3) binds VEGF-C and VEGF-D and is essential for the development of the lymphatic vasculature. Experimental tumors that overexpress VEGFR-3 ligands induce lymphatic vessel sprouting and enlargement and show enhanced metastasis to regional lymph nodes and beyond, whereas a soluble form of VEGFR-3 that blocks receptor signaling inhibits these changes and metastasis. Because VEGFR-3 is also essential for the early blood vessel development in embryos and is up-regulated in tumor angiogenesis, we wanted to determine if an antibody targeting the receptor that interferes with VEGFR-3 ligand binding can inhibit primary tumor growth. Our results show that antibody interference with VEGFR-3 function can inhibit the growth of several human tumor xenografts in immunocompromised mice. Immunohistochemical analysis showed that the blood vessel density of anti-VEGFR-3-treated tumors was significantly decreased and hypoxic and necrotic tumor tissue wa
@article{Laakkonen.2007,
abstract = {Vascular endothelial growth factor receptor 3 (VEGFR-3) binds VEGF-C and VEGF-D and is essential for the development of the lymphatic vasculature. Experimental tumors that overexpress VEGFR-3 ligands induce lymphatic vessel sprouting and enlargement and show enhanced metastasis to regional lymph nodes and beyond, whereas a soluble form of VEGFR-3 that blocks receptor signaling inhibits these changes and metastasis. Because VEGFR-3 is also essential for the early blood vessel development in embryos and is up-regulated in tumor angiogenesis, we wanted to determine if an antibody targeting the receptor that interferes with VEGFR-3 ligand binding can inhibit primary tumor growth. Our results show that antibody interference with VEGFR-3 function can inhibit the growth of several human tumor xenografts in immunocompromised mice. Immunohistochemical analysis showed that the blood vessel density of anti-VEGFR-3-treated tumors was significantly decreased and hypoxic and necrotic tumor tissue wa},
added-at = {2010-02-05T11:28:39.000+0100},
author = {Laakkonen, P. and Waltari, M. and Holopainen, T. and Takahashi, T. and Pytowski, B. and Steiner, P. and Hicklin, D. and Persaud, K. and Tonra, J. R. and Witte, L. and Alitalo, K.},
biburl = {https://www.bibsonomy.org/bibtex/21d3ba1cc74ddebe211f5e063d1db007f/kanefendt},
interhash = {ec527ac8f826b9d208d3fb9eba6ad618},
intrahash = {1d3ba1cc74ddebe211f5e063d1db007f},
journal = {Cancer Res.},
keywords = {& Animals Antibodies Antitumor Assays BALB Binding C Cell D Endothelial Factor Growth Human Humans Immunohistochemistry Inbred Ligands Mice Model Monoclonal Neoplasms Neovascularization Nude Pathologic Processes Receptor-3 Research Vascular Xenograft analysis antagonists blood immunology inhibitors metabolism pharmacology supply therapy},
number = 2,
pages = {593-599},
timestamp = {2010-02-05T11:28:56.000+0100},
title = {Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth},
url = {PM:17234768},
volume = 67,
year = 2007
}