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Sunitinib induced hypertension, thrombotic microangiopathy and reversible posterior leukencephalopathy syndrome
E. Kapiteijn
,
A. Brand
,
J. Kroep
, and
H. Gelderblom
.
Ann.Oncol.
18(10):1745-1747
(
2007
)
E. Kapiteijn
,
A. Brand
,
J. Kroep
, and
H. Gelderblom
.
Ann.Oncol.
18(10):1745-1747
(
2007
)
3 years and 3 months ago
by
kanefendt
1
&
A
Aged
Agents
Antineoplastic
Endothelial
Factor
Female
Growth
Humans
Hypertension
Indoles
Middle
Neurotoxicity
Purpura
Pyrroles
Receptor-2
Syndromes
Thrombocytopenic
Thrombotic
Vascular
adverse
antagonists
chemically
effects
etiology
induced
inhibitors
&
A
Aged
Agents
Antineoplastic
Endothelial
Factor
Female
Growth
Humans
Hypertension
Indoles
Middle
Neurotoxicity
Purpura
Pyrroles
Receptor-2
Syndromes
Thrombocytopenic
Thrombotic
Vascular
adverse
antagonists
chemically
effects
etiology
induced
inhibitors
(0)
URL
DOI
TeX
Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization
D. Fukumura
, and
R. K. Jain
.
Microvasc.Res.
74(2-3):72-84
(
2007
)
D. Fukumura
, and
R. K. Jain
.
Microvasc.Res.
74(2-3):72-84
(
2007
)
3 years and 3 months ago
by
kanefendt
1
&
Angiogenesis
Animals
Blood
Endothelial
Factors
Growth
Humans
Inhibitors
Laboratories
Neoplasms
Neovascularization
Pathologic
Research
Vascular
Vessels
antagonists
blood
cells
drug
inhibitors
pathology
supply
therapeutic
therapy
use
&
Angiogenesis
Animals
Blood
Endothelial
Factors
Growth
Humans
Inhibitors
Laboratories
Neoplasms
Neovascularization
Pathologic
Research
Vascular
Vessels
antagonists
blood
cells
drug
inhibitors
pathology
supply
therapeutic
therapy
use
(0)
URL
DOI
TeX
Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage
N. Henke
,
R. Schmidt-Ullrich
,
R. Dechend
,
J. K. Park
,
F. Qadri
,
M. Wellner
,
M. Obst
,
V. Gross
,
R. Dietz
,
F. C. Luft
,
C. Scheidereit
, and
D. N. Muller
.
Circ.Res.
101(3):268-276
(
2007
)
N. Henke
,
R. Schmidt-Ullrich
,
R. Dechend
,
J. K. Park
,
F. Qadri
,
M. Wellner
,
M. Obst
,
V. Gross
,
R. Dietz
,
F. C. Luft
,
C. Scheidereit
, and
D. N. Muller
.
Circ.Res.
101(3):268-276
(
2007
)
3 years and 3 months ago
by
kanefendt
1
&
Adhesion
Albuminuria
Angiotensin
Animals
Atherosclerosis
B
Blood
C57BL
Cardiovascular
Cell
Cells
Chain
Chloride
Cultured
Dietary
Diseases
Endothelial
Ester
Expression
Factor-alpha
Fusion
Gene
Humans
Hypertension
I-kappa
II
III
Inbred
Inflammation
Intercellular
Kidney
Methyl
Mice
Models
Molecule-1
NF-kappa
NG-Nitroarginine
Necrosis
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Oxide
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Pressure
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Recombinant
Regulation
Research
Reverse
Signal
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Specificity
Synthase
TIE-1
Transcriptase
Transduction
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Type
Vascular
antagonists
biosynthesis
blood
cells
complications
control
etiology
genetics
inhibitors
metabolism
physiology
physiopathology
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protein
toxicity
&
Adhesion
Albuminuria
Angiotensin
Animals
Atherosclerosis
B
Blood
C57BL
Cardiovascular
Cell
Cells
Chain
Chloride
Cultured
Dietary
Diseases
Endothelial
Ester
Expression
Factor-alpha
Fusion
Gene
Humans
Hypertension
I-kappa
II
III
Inbred
Inflammation
Intercellular
Kidney
Methyl
Mice
Models
Molecule-1
NF-kappa
NG-Nitroarginine
Necrosis
Nephritis
Nitric
Organ
Oxide
Polymerase
Pressure
Proteins
Reaction
Receptor
Recombinant
Regulation
Research
Reverse
Signal
Sodium
Specificity
Synthase
TIE-1
Transcriptase
Transduction
Transgenic
Tumor
Type
Vascular
antagonists
biosynthesis
blood
cells
complications
control
etiology
genetics
inhibitors
metabolism
physiology
physiopathology
prevention
protein
toxicity
(0)
URL
DOI
TeX
Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth
P. Laakkonen
,
M. Waltari
,
T. Holopainen
,
T. Takahashi
,
B. Pytowski
,
P. Steiner
,
D. Hicklin
,
K. Persaud
,
J. R. Tonra
,
L. Witte
, and
K. Alitalo
.
Cancer Res.
67(2):593-599
(
2007
)
P. Laakkonen
,
M. Waltari
,
T. Holopainen
,
T. Takahashi
,
B. Pytowski
,
P. Steiner
,
D. Hicklin
,
K. Persaud
,
J. R. Tonra
,
L. Witte
, and
K. Alitalo
.
Cancer Res.
67(2):593-599
(
2007
)
3 years and 3 months ago
by
kanefendt
1
&
Animals
Antibodies
Antitumor
Assays
BALB
Binding
C
Cell
D
Endothelial
Factor
Growth
Human
Humans
Immunohistochemistry
Inbred
Ligands
Mice
Model
Monoclonal
Neoplasms
Neovascularization
Nude
Pathologic
Processes
Receptor-3
Research
Vascular
Xenograft
analysis
antagonists
blood
immunology
inhibitors
metabolism
pharmacology
supply
therapy
&
Animals
Antibodies
Antitumor
Assays
BALB
Binding
C
Cell
D
Endothelial
Factor
Growth
Human
Humans
Immunohistochemistry
Inbred
Ligands
Mice
Model
Monoclonal
Neoplasms
Neovascularization
Nude
Pathologic
Processes
Receptor-3
Research
Vascular
Xenograft
analysis
antagonists
blood
immunology
inhibitors
metabolism
pharmacology
supply
therapy
(0)
URL
DOI
TeX
Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib
T. F. Chu
,
M. A. Rupnick
,
R. Kerkela
,
S. M. Dallabrida
,
D. Zurakowski
,
L. Nguyen
,
K. Woulfe
,
E. Pravda
,
F. Cassiola
,
J. Desai
,
S. George
,
J. A. Morgan
,
D. M. Harris
,
N. S. Ismail
,
J. H. Chen
,
F. J. Schoen
,
A. D. van den Abbeele
,
G. D. Demetri
,
T. Force
, and
M. H. Chen
.
Lancet
370(9604):2011-2019
(
2007
)
T. F. Chu
,
M. A. Rupnick
,
R. Kerkela
,
S. M. Dallabrida
,
D. Zurakowski
,
L. Nguyen
,
K. Woulfe
,
E. Pravda
,
F. Cassiola
,
J. Desai
,
S. George
,
J. A. Morgan
,
D. M. Harris
,
N. S. Ismail
,
J. H. Chen
,
F. J. Schoen
,
A. D. van den Abbeele
,
G. D. Demetri
,
T. Force
, and
M. H. Chen
.
Lancet
370(9604):2011-2019
(
2007
)
3 years and 3 months ago
by
kanefendt
1
&
Aged
Agents
Animals
Antineoplastic
Arteries
Artery
Blood
Carcinoma
Coronary
Disease
Failure
Female
Gastrointestinal
Heart
Humans
Hypertension
Indoles
Kinase
Kinases
Male
Mice
Middle
Multicenter
Pressure
Protein-Tyrosine
Pyrroles
Rats
Research
Retrospective
Safety
Stroke
Stromal
Studies
Topic
Tumors
Tyrosine
Volume
adverse
antagonists
as
blood
chemically
drug
effects
induced
inhibitors
methods
therapeutic
therapy
toxicity
use
&
Aged
Agents
Animals
Antineoplastic
Arteries
Artery
Blood
Carcinoma
Coronary
Disease
Failure
Female
Gastrointestinal
Heart
Humans
Hypertension
Indoles
Kinase
Kinases
Male
Mice
Middle
Multicenter
Pressure
Protein-Tyrosine
Pyrroles
Rats
Research
Retrospective
Safety
Stroke
Stromal
Studies
Topic
Tumors
Tyrosine
Volume
adverse
antagonists
as
blood
chemically
drug
effects
induced
inhibitors
methods
therapeutic
therapy
toxicity
use
(0)
URL
DOI
TeX
Surrogate biomarkers in evaluating response to anti-angiogenic agents: focus on sunitinib
S. E. Deprimo
, and
C. Bello
.
Ann.Oncol
(
2007
)
S. E. Deprimo
, and
C. Bello
.
Ann.Oncol
(
2007
)
3 years and 3 months ago
by
kanefendt
1
Angiogenesis
Biological
Cells
Endothelial
Growth
Humans
Indoles
Inhibitors
Laboratories
Markers
Neoplasms
Neovascularization
Pathologic
Proteins
Pyrroles
Research
Tumor
blood
cells
diagnosis
drug
effects
metabolism
methods
pathology
pharmacology
protein
response
supply
therapeutic
therapy
use
Angiogenesis
Biological
Cells
Endothelial
Growth
Humans
Indoles
Inhibitors
Laboratories
Markers
Neoplasms
Neovascularization
Pathologic
Proteins
Pyrroles
Research
Tumor
blood
cells
diagnosis
drug
effects
metabolism
methods
pathology
pharmacology
protein
response
supply
therapeutic
therapy
use
(0)
URL
DOI
TeX
Molecular and cellular biomarkers for angiogenesis in clinical oncology
F. Bertolini
,
P. Mancuso
,
Y. Shaked
, and
R. S. Kerbel
.
Drug Discov.Today
12(19-20):806-812
(
2007
)
F. Bertolini
,
P. Mancuso
,
Y. Shaked
, and
R. S. Kerbel
.
Drug Discov.Today
12(19-20):806-812
(
2007
)
3 years and 3 months ago
by
kanefendt
1
Angiogenesis
Antigens
Biological
Cells
Endothelial
Humans
Inhibitors
Markers
Microcirculation
Neoplasms
Neovascularization
Pathologic
Research
Tumor
blood
cells
diagnosis
drug
metabolism
pathology
pharmacology
supply
therapeutic
therapy
use
Angiogenesis
Antigens
Biological
Cells
Endothelial
Humans
Inhibitors
Markers
Microcirculation
Neoplasms
Neovascularization
Pathologic
Research
Tumor
blood
cells
diagnosis
drug
metabolism
pathology
pharmacology
supply
therapeutic
therapy
use
(0)
URL
DOI
TeX
Surrogate predictive biomarkers for response to anti-EGFR agents: state of the art and challenges
F. Cappuzzo
,
L. Toschi
,
G. Finocchiaro
,
C. Ligorio
, and
A. Santoro
.
Int.J.Biol.Markers
22(1 Suppl 4):S10-S23
(
2007
)
F. Cappuzzo
,
L. Toschi
,
G. Finocchiaro
,
C. Ligorio
, and
A. Santoro
.
Int.J.Biol.Markers
22(1 Suppl 4):S10-S23
(
2007
)
3 years and 3 months ago
by
kanefendt
2
&
Antibodies
Biological
Carcinoma
Dosage
Drug
Epidermal
Factor
Gene
Growth
Human
Humans
Immunohistochemistry
Inhibitors
Kinase
Kinases
Lung
Markers
Monoclonal
Mutation
Neoplasm
Neoplasms
Non-Small-Cell
Phosphoproteins
Predictive
Protein
Protein-Tyrosine
Proteins
Proto-Oncogene
Quinazolines
Receptor
Resistance
Tests
Tyrosine
Value
analysis
antagonists
c-akt
drug
effects
erbB-2
erbB-3
genetics
identify
inhibitors
of
protein
response
therapeutic
therapy
use
&
Antibodies
Biological
Carcinoma
Dosage
Drug
Epidermal
Factor
Gene
Growth
Human
Humans
Immunohistochemistry
Inhibitors
Kinase
Kinases
Lung
Markers
Monoclonal
Mutation
Neoplasm
Neoplasms
Non-Small-Cell
Phosphoproteins
Predictive
Protein
Protein-Tyrosine
Proteins
Proto-Oncogene
Quinazolines
Receptor
Resistance
Tests
Tyrosine
Value
analysis
antagonists
c-akt
drug
effects
erbB-2
erbB-3
genetics
identify
inhibitors
of
protein
response
therapeutic
therapy
use
(0)
URL
DOI
TeX
Severe cardiomyopathy in a patient with renal cell carcinoma after treatment with the novel tyrosine kinase inhibitor sunitinib
E. Chorianopoulos
,
D. Jager
,
H. A. Katus
, and
N. Frey
.
Clin.Res.Cardiol.
96(11):829-830
(
2007
)
E. Chorianopoulos
,
D. Jager
,
H. A. Katus
, and
N. Frey
.
Clin.Res.Cardiol.
96(11):829-830
(
2007
)
3 years and 3 months ago
by
kanefendt
1
&
Aged
Agents
Angiogenesis
Antineoplastic
Carcinoma
Cardiomyopathies
Cell
Dysfunction
Echocardiography
Female
Humans
Illness
Index
Indoles
Inhibitors
Kidney
Kinase
Kinases
Left
Neoplasms
Protein-Tyrosine
Pyrroles
Renal
Severity
Tyrosine
Ventricular
adverse
antagonists
chemically
contraindications
drug
effects
induced
inhibitors
of
therapy
&
Aged
Agents
Angiogenesis
Antineoplastic
Carcinoma
Cardiomyopathies
Cell
Dysfunction
Echocardiography
Female
Humans
Illness
Index
Indoles
Inhibitors
Kidney
Kinase
Kinases
Left
Neoplasms
Protein-Tyrosine
Pyrroles
Renal
Severity
Tyrosine
Ventricular
adverse
antagonists
chemically
contraindications
drug
effects
induced
inhibitors
of
therapy
(0)
URL
DOI
TeX
Angiogenesis: an organizing principle for drug discovery?
J. Folkman
.
Nat.Rev.Drug Discov.
6(4):273-286
(
2007
)
J. Folkman
.
Nat.Rev.Drug Discov.
6(4):273-286
(
2007
)
3 years and 3 months ago
by
kanefendt
1
Agents
Angiogenesis
Animals
Antineoplastic
Blood
Endothelium
Humans
Inhibitors
Neoplasms
Neovascularization
Pathologic
Physiologic
Platelets
RANGE
Research
drug
effects
genetics
pathology
pharmacology
physiology
therapeutic
therapy
use
Agents
Angiogenesis
Animals
Antineoplastic
Blood
Endothelium
Humans
Inhibitors
Neoplasms
Neovascularization
Pathologic
Physiologic
Platelets
RANGE
Research
drug
effects
genetics
pathology
pharmacology
physiology
therapeutic
therapy
use
(0)
URL
DOI
TeX
Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition
T. Force
,
D. S. Krause
, and
R. A. van Etten
.
Nat.Rev.Cancer
7(5):332-344
(
2007
)
T. Force
,
D. S. Krause
, and
R. A. van Etten
.
Nat.Rev.Cancer
7(5):332-344
(
2007
)
3 years and 3 months ago
by
kanefendt
1
&
Adaptor
Antibodies
Benzenesulfonates
Biological
Delivery
Diseases
Drug
Enzyme
Heart
Human
Humans
Indoles
Inhibitors
Kinase
Kinases
Models
Monoclonal
Mutation
Neoplasms
Protein
Protein-Tyrosine
Proteins
Proto-Oncogene
Pyridines
Pyrroles
Quinazolines
Research
Signal
Systems
Transducing
Tyrosine
adverse
antagonists
c-abl
cells
chemically
development
drug
effects
growth
induced
inhibitors
physiology
protein
response
therapy
toxicity
&
Adaptor
Antibodies
Benzenesulfonates
Biological
Delivery
Diseases
Drug
Enzyme
Heart
Human
Humans
Indoles
Inhibitors
Kinase
Kinases
Models
Monoclonal
Mutation
Neoplasms
Protein
Protein-Tyrosine
Proteins
Proto-Oncogene
Pyridines
Pyrroles
Quinazolines
Research
Signal
Systems
Transducing
Tyrosine
adverse
antagonists
c-abl
cells
chemically
development
drug
effects
growth
induced
inhibitors
physiology
protein
response
therapy
toxicity
(0)
URL
DOI
TeX
Molecular basis for sunitinib efficacy and future clinical development
S. Faivre
,
G. Demetri
,
W. Sargent
, and
E. Raymond
.
Nat.Rev.Drug Discov.
6(9):734-745
(
2007
)
S. Faivre
,
G. Demetri
,
W. Sargent
, and
E. Raymond
.
Nat.Rev.Drug Discov.
6(9):734-745
(
2007
)
3 years and 3 months ago
by
kanefendt
1
&
A
Angiogenesis
Animals
Carcinoma
Clinical
Design
Drug
Endothelial
Factor
France
Growth
Humans
Indoles
Inhibitors
Kinase
Kinases
Neoplasm
Neoplasms
Protein-Tyrosine
Pyrroles
Receptors
Resistance
Topic
Trials
Tyrosine
Vascular
adverse
antagonists
as
biosynthesis
blood
drug
effects
enzymology
inhibitors
metabolism
pharmacology
response
supply
therapeutic
therapy
use
&
A
Angiogenesis
Animals
Carcinoma
Clinical
Design
Drug
Endothelial
Factor
France
Growth
Humans
Indoles
Inhibitors
Kinase
Kinases
Neoplasm
Neoplasms
Protein-Tyrosine
Pyrroles
Receptors
Resistance
Topic
Trials
Tyrosine
Vascular
adverse
antagonists
as
biosynthesis
blood
drug
effects
enzymology
inhibitors
metabolism
pharmacology
response
supply
therapeutic
therapy
use
(0)
URL
DOI
TeX
Molecular regulation of tumor angiogenesis: mechanisms and therapeutic implications
J. Harper
, and
M. A. Moses
.
EXS
(
2006
)
J. Harper
, and
M. A. Moses
.
EXS
(
2006
)
3 years and 3 months ago
by
kanefendt
1
&
Angiogenesis
Capillaries
Human
Humans
Inhibitors
Neoplasms
Neovascularization
Pathologic
Research
blood
control
drug
metabolism
pathology
pharmacology
prevention
supply
therapeutic
therapy
use
&
Angiogenesis
Capillaries
Human
Humans
Inhibitors
Neoplasms
Neovascularization
Pathologic
Research
blood
control
drug
metabolism
pathology
pharmacology
prevention
supply
therapeutic
therapy
use
(0)
URL
DOI
TeX
The clinical toxicity profile of vascular endothelial growth factor VEGF and vascular endothelial growth factor receptor VEGFR targeting angiogenesis inhibitors; a review
F. A. Eskens
, and
J. Verweij
.
Eur.J.Cancer
42(18):3127-3139
(
2006
)
F. A. Eskens
, and
J. Verweij
.
Eur.J.Cancer
42(18):3127-3139
(
2006
)
3 years and 3 months ago
by
kanefendt
1
&
A
Angiogenesis
Antibodies
Endothelial
Factor
Growth
Humans
Inhibitors
Kinase
Kinases
Medical
Monoclonal
Neoplasms
Neovascularization
Oncology
Pathologic
Protein
Protein-Tyrosine
Receptors
Tyrosine
Vascular
adverse
antagonists
blood
control
drug
effects
inhibitors
prevention
protein
supply
therapy
toxicity
&
A
Angiogenesis
Antibodies
Endothelial
Factor
Growth
Humans
Inhibitors
Kinase
Kinases
Medical
Monoclonal
Neoplasms
Neovascularization
Oncology
Pathologic
Protein
Protein-Tyrosine
Receptors
Tyrosine
Vascular
adverse
antagonists
blood
control
drug
effects
inhibitors
prevention
protein
supply
therapy
toxicity
(0)
URL
DOI
TeX
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