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Study of interaction between agonists and asn293 in helix VI of human beta2-adrenergic receptor
H. M. Zuurmond, J. Hessling, K. Bluml, M. Lohse, and A. P. Ijzerman. Mol Pharmacol 56(5):909-16 (November 1999)Zuurmond, H M Hessling, J Bluml, K Lohse, M Ijzerman, A P Research Support, Non-U.S. Gov't United states Molecular pharmacology Mol Pharmacol. 1999 Nov;565:909-16..
H. M. Zuurmond, J. Hessling, K. Bluml, M. Lohse, and A. P. Ijzerman. Mol Pharmacol 56(5):909-16 (November 1999)Zuurmond, H M Hessling, J Bluml, K Lohse, M Ijzerman, A P Research Support, Non-U.S. Gov't United states Molecular pharmacology Mol Pharmacol. 1999 Nov;565:909-16..
2 years and 5 months ago
by pharmawuerz
2
& Adrenergic Animals Asparagine/*metabolism Binding, CHO Clenbuterol/analogs Competitive Cricetinae Humans Isoproterenol/analogs Ligands Models, Molecular Protein Secondary Spectrophotometry, Structure, Ultraviolet beta-2/chemistry/genetics/*metabolism beta-Agonists/chemical derivatives/chemical synthesis/*pharmacology synthesis/pharmacology Receptor Cell
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Autoradiographic visualization of A1 adenosine receptors in rat brain with 3H8-cyclopentyl-1,3-dipropylxanthine
R. G. Weber, C. R. Jones, M. J. Lohse, and J. M. Palacios. J Neurochem 54(4):1344-53 (April 1990)Weber, R G Jones, C R Lohse, M J Palacios, J M Research Support, Non-U.S. Gov't United states Journal of neurochemistry J Neurochem. 1990 Apr;544:1344-53..
R. G. Weber, C. R. Jones, M. J. Lohse, and J. M. Palacios. J Neurochem 54(4):1344-53 (April 1990)Weber, R G Jones, C R Lohse, M J Palacios, J M Research Support, Non-U.S. Gov't United states Journal of neurochemistry J Neurochem. 1990 Apr;544:1344-53..
2 years and 5 months ago
by pharmawuerz
2
Animals Autoradiography Binding Binding, Brain/*metabolism Competitive Factors Guanosine Male Phenylisopropyladenosine/metabolism Purinergic/*metabolism Rats Sites Strains Time Triphosphate/pharmacology Tritium/diagnostic Xanthines/*diagnostic use use/metabolism Receptor Mice
(0)
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Differential conformational requirements for activation of G proteins and the regulatory proteins arrestin and G protein-coupled receptor kinase in the G protein-coupled receptor for parathyroid hormone PTH/PTH-related protein
J. P. Vilardaga, M. Frank, C. Krasel, C. Dees, R. A. Nissenson, and M. J. Lohse. J Biol Chem 276(36):33435-43 (September 2001)Vilardaga, J P Frank, M Krasel, C Dees, C Nissenson, R A Lohse, M J Research Support, Non-U.S. Gov't United States The Journal of biological chemistry J Biol Chem. 2001 Sep 7;27636:33435-43. Epub 2001 May 31..
J. P. Vilardaga, M. Frank, C. Krasel, C. Dees, R. A. Nissenson, and M. J. Lohse. J Biol Chem 276(36):33435-43 (September 2001)Vilardaga, J P Frank, M Krasel, C Dees, C Nissenson, R A Lohse, M J Research Support, Non-U.S. Gov't United States The Journal of biological chemistry J Biol Chem. 2001 Sep 7;27636:33435-43. Epub 2001 May 31..
2 years and 5 months ago
by pharmawuerz
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1 50 AMP/metabolism Activation Animals Arrestin/*metabolism Arrestins/metabolism Binding Binding, COS Cell Chlorides/pharmacology Competitive Compounds/pharmacology Concentration Conformation Cyclic Dose-Response Drug Enzyme Factors GTP-Binding Histidine/chemistry Hormone, Hormone/*metabolism Immunoblotting Inhibitory Inositol Ions/metabolism Kinases/*metabolism Kinetics Ligands Membrane/metabolism Mutation Parathyroid Phosphates/metabolism Phosphorylation Protein Protein-Serine-Threonine Relationship, Signal Sites Time Transduction Type Zinc Zinc/metabolism Receptor Proteins/metabolism
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3HMRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A3 adenosine receptors
K. Varani, S. Merighi, S. Gessi, K. N. Klotz, E. Leung, P. G. Baraldi, B. Cacciari, R. Romagnoli, G. Spalluto, and P. A. Borea. Mol Pharmacol 57(5):968-75 (May 2000)Varani, K Merighi, S Gessi, S Klotz, K N Leung, E Baraldi, P G Cacciari, B Romagnoli, R Spalluto, G Borea, P A United states Molecular pharmacology Mol Pharmacol. 2000 May;575:968-75..
K. Varani, S. Merighi, S. Gessi, K. N. Klotz, E. Leung, P. G. Baraldi, B. Cacciari, R. Romagnoli, G. Spalluto, and P. A. Borea. Mol Pharmacol 57(5):968-75 (May 2000)Varani, K Merighi, S Gessi, S Klotz, K N Leung, E Baraldi, P G Cacciari, B Romagnoli, R Spalluto, G Borea, P A United states Molecular pharmacology Mol Pharmacol. 2000 May;575:968-75..
2 years and 5 months ago
by pharmawuerz
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& A3 AMP/metabolism Adenosine Adenosine/analogs Adenylate Animals Assay Binding, CHO Competitive Compounds/chemistry/*pharmacology Cricetinae Cyclase/antagonists Cyclic Dose-Response Drug Humans P1/*antagonists Phenylurea Purinergic Radioligand Rats Relationship, Triazoles/chemistry/*pharmacology Tritium derivatives/pharmacology inhibitors inhibitors/metabolism Receptor Cell
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Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors
K. Varani, S. Gessi, S. Merighi, F. Vincenzi, E. Cattabriga, A. Benini, K. N. Klotz, P. G. Baraldi, M. A. Tabrizi, S. M. Lennan, E. Leung, and P. A. Borea. Biochem Pharmacol 70(11):1601-12 (November 2005)Varani, Katia Gessi, Stefania Merighi, Stefania Vincenzi, Fabrizio Cattabriga, Elena Benini, Annalisa Klotz, Karl-Norbert Baraldi, Pier Giovanni Tabrizi, Mojgan Aghazadeh Lennan, Stephen Mac Leung, Edward Borea, Pier Andrea England Biochemical pharmacology Biochem Pharmacol. 2005 Nov 25;7011:1601-12. Epub 2005 Oct 10..
K. Varani, S. Gessi, S. Merighi, F. Vincenzi, E. Cattabriga, A. Benini, K. N. Klotz, P. G. Baraldi, M. A. Tabrizi, S. M. Lennan, E. Leung, and P. A. Borea. Biochem Pharmacol 70(11):1601-12 (November 2005)Varani, Katia Gessi, Stefania Merighi, Stefania Vincenzi, Fabrizio Cattabriga, Elena Benini, Annalisa Klotz, Karl-Norbert Baraldi, Pier Giovanni Tabrizi, Mojgan Aghazadeh Lennan, Stephen Mac Leung, Edward Borea, Pier Andrea England Biochemical pharmacology Biochem Pharmacol. 2005 Nov 25;7011:1601-12. Epub 2005 Oct 10..
2 years and 5 months ago
by pharmawuerz
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& A2B/antagonists AMP/metabolism Adenosine Adenosine/chemistry/*metabolism/*pharmacology Animals Binding Binding, Cell Competitive Cyclic Humans Line Molecular Protein Proteins Recombinant Structure inhibitors/genetics/*metabolism Receptor
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Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart
M. Ungerer, M. Bohm, J. S. Elce, E. Erdmann, and M. J. Lohse. Circulation 87(2):454-63 (February 1993)Ungerer, M Bohm, M Elce, J S Erdmann, E Lohse, M J In Vitro Research Support, Non-U.S. Gov't United states Circulation Circulation. 1993 Feb;872:454-63..
M. Ungerer, M. Bohm, J. S. Elce, E. Erdmann, and M. J. Lohse. Circulation 87(2):454-63 (February 1993)Ungerer, M Bohm, M Elce, J S Erdmann, E Lohse, M J In Vitro Research Support, Non-U.S. Gov't United states Circulation Circulation. 1993 Feb;872:454-63..
2 years and 5 months ago
by pharmawuerz
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*Cyclic AMP-Dependent Adult Aged Base Binding, Calcium/pharmacology Cardiac Cardiomyopathy, Chain Competitive Contraction/drug Coronary Data Dilated/metabolism Disease/metabolism Electric Female Forskolin/pharmacology Humans Isoproterenol/pharmacology Kinases Kinases/genetics/*metabolism Low/*metabolism/physiopathology Male Messenger/metabolism Middle Molecular Muscles/drug Myocardial Oligonucleotide Output, Papillary Polymerase Probes/genetics Protein RNA, Reaction Receptor Sequence Stimulation beta-Adrenergic beta/genetics/metabolism effects Adrenergic
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Agonist-induced internalization and recycling of the human A3 adenosine receptors: role in receptor desensitization and resensitization
M. L. Trincavelli, D. Tuscano, P. Cecchetti, A. Falleni, L. Benzi, K. N. Klotz, V. Gremigni, F. Cattabeni, A. Lucacchini, and C. Martini. J Neurochem 75(4):1493-501 (October 2000)Trincavelli, M L Tuscano, D Cecchetti, P Falleni, A Benzi, L Klotz, K N Gremigni, V Cattabeni, F Lucacchini, A Martini, C Research Support, Non-U.S. Gov't United states Journal of neurochemistry J Neurochem. 2000 Oct;754:1493-501..
M. L. Trincavelli, D. Tuscano, P. Cecchetti, A. Falleni, L. Benzi, K. N. Klotz, V. Gremigni, F. Cattabeni, A. Lucacchini, and C. Martini. J Neurochem 75(4):1493-501 (October 2000)Trincavelli, M L Tuscano, D Cecchetti, P Falleni, A Benzi, L Klotz, K N Gremigni, V Cattabeni, F Lucacchini, A Martini, C Research Support, Non-U.S. Gov't United states Journal of neurochemistry J Neurochem. 2000 Oct;754:1493-501..
2 years and 5 months ago
by pharmawuerz
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& A/pharmacology A3 Adenosine Adenosine/*analogs Affinity Animals Assay Binding, CHO Cell Competitive/drug Concanavalin Concentration Cricetinae Dose-Response Drug Endocytosis/drug Humans Hydrogen-Ion Hypertonic Immunohistochemistry Iodine Labels/pharmacokinetics Ligands Membrane/metabolism P1/*agonists/genetics/*metabolism Potassium/metabolism Purinergic Radioisotopes/analysis Radioligand Relationship, Signal Solutions/pharmacology Temperature Transduction/drug Transfection derivatives/pharmacokinetics effects effects/*physiology effects/genetics Receptor
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Characterization of adenosine A1 receptor in a cell line 28A derived from rabbit collecting tubule
W. S. Spielman, K. N. Klotz, L. J. Arend, B. A. Olson, D. G. LeVier, and U. Schwabe. Am J Physiol 263(2 Pt 1):C502-8 (August 1992)Spielman, W S Klotz, K N Arend, L J Olson, B A LeVier, D G Schwabe, U R01 DK-39654/DK/NIDDK NIH HHS/United States Research Support, U.S. Gov't, P.H.S. United states The American journal of physiology Am J Physiol. 1992 Aug;2632 Pt 1:C502-8..
W. S. Spielman, K. N. Klotz, L. J. Arend, B. A. Olson, D. G. LeVier, and U. Schwabe. Am J Physiol 263(2 Pt 1):C502-8 (August 1992)Spielman, W S Klotz, K N Arend, L J Olson, B A LeVier, D G Schwabe, U R01 DK-39654/DK/NIDDK NIH HHS/United States Research Support, U.S. Gov't, P.H.S. United states The American journal of physiology Am J Physiol. 1992 Aug;2632 Pt 1:C502-8..
2 years and 5 months ago
by pharmawuerz
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& AMP/antagonists Adenosine/analogs Adenylate Animals Binding, Bordetella/pharmacology Brain/metabolism Calcium/metabolism Cell Collecting/cytology/*metabolism Competitive Cyclase Cyclic Factors, Kidney Line Medulla/metabolism Membrane/metabolism Pertussis Purinergic/classification/drug Rabbits Toxin Tubules, Virulence Xanthines/pharmacology derivatives/pharmacology effects/*metabolism inhibitors Receptor
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2-Benzimidazol-2-ylquinoxalines: a novel class of selective antagonists at human A1 and A3 adenosine receptors designed by 3D database searching
E. Novellino, B. Cosimelli, M. Ehlardo, G. Greco, M. Iadanza, A. Lavecchia, M. G. Rimoli, A. Sala, A. Da Settimo, G. Primofiore, F. Da Settimo, S. Taliani, C. La Motta, K. N. Klotz, D. Tuscano, M. L. Trincavelli, and C. Martini. J Med Chem 48(26):8253-60 (December 2005)Novellino, Ettore Cosimelli, Barbara Ehlardo, Marina Greco, Giovanni Iadanza, Manuela Lavecchia, Antonio Rimoli, Maria Grazia Sala, Annalisa Da Settimo, Antonio Primofiore, Giampaolo Da Settimo, Federico Taliani, Sabrina La Motta, Concettina Klotz, Karl-Norbert Tuscano, Daniela Trincavelli, Maria Letizia Martini, Claudia Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2005 Dec 29;4826:8253-60..
E. Novellino, B. Cosimelli, M. Ehlardo, G. Greco, M. Iadanza, A. Lavecchia, M. G. Rimoli, A. Sala, A. Da Settimo, G. Primofiore, F. Da Settimo, S. Taliani, C. La Motta, K. N. Klotz, D. Tuscano, M. L. Trincavelli, and C. Martini. J Med Chem 48(26):8253-60 (December 2005)Novellino, Ettore Cosimelli, Barbara Ehlardo, Marina Greco, Giovanni Iadanza, Manuela Lavecchia, Antonio Rimoli, Maria Grazia Sala, Annalisa Da Settimo, Antonio Primofiore, Giampaolo Da Settimo, Federico Taliani, Sabrina La Motta, Concettina Klotz, Karl-Norbert Tuscano, Daniela Trincavelli, Maria Letizia Martini, Claudia Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2005 Dec 29;4826:8253-60..
2 years and 5 months ago
by pharmawuerz
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& *Databases, A1/*antagonists A2A/metabolism A3/*antagonists Adenosine Adenosine-5'-(N-ethylcarboxamide)/metabolism Adenosine/analogs Animals Benzimidazoles/*chemical Binding, CHO Competitive Cricetinae Design Drug Factual Humans Quinoxalines/*chemical Xanthines/metabolism derivatives/metabolism inhibitors/chemistry/metabolism synthesis/chemistry Receptor Cell
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Interaction of barbiturates with adenosine receptors in rat brain
M. J. Lohse, V. Lenschow, and U. Schwabe. Naunyn Schmiedebergs Arch Pharmacol 326(1):69-74 (May 1984)Lohse, M J Lenschow, V Schwabe, U In Vitro Research Support, Non-U.S. Gov't Germany, west Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 1984 May;3261:69-74..
M. J. Lohse, V. Lenschow, and U. Schwabe. Naunyn Schmiedebergs Arch Pharmacol 326(1):69-74 (May 1984)Lohse, M J Lenschow, V Schwabe, U In Vitro Research Support, Non-U.S. Gov't Germany, west Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 1984 May;3261:69-74..
2 years and 5 months ago
by pharmawuerz
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& Adenosine/*metabolism Animals Barbiturates/*pharmacology Binding, Brain Cell Chemistry/*drug Competitive/drug Drug Guanosine Interactions Kinetics Male Phenylisopropyladenosine/pharmacology Picrotoxin/analogs Purinergic Rats Strains Surface/*metabolism Synaptosomes/metabolism Triphosphate/pharmacology Xanthines/pharmacology derivatives/pharmacology effects Receptor Mice
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URLDOITeX
8-Cyclopentyl-1,3-dipropylxanthine DPCPX--a selective high affinity antagonist radioligand for A1 adenosine receptors
M. J. Lohse, K. N. Klotz, J. Lindenborn-Fotinos, M. Reddington, U. Schwabe, and R. A. Olsson. Naunyn Schmiedebergs Arch Pharmacol 336(2):204-10 (August 1987)Lohse, M J Klotz, K N Lindenborn-Fotinos, J Reddington, M Schwabe, U Olsson, R A HL-30391/HL/NHLBI NIH HHS/United States Comparative Study In Vitro Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Germany, west Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 1987 Aug;3362:204-10..
M. J. Lohse, K. N. Klotz, J. Lindenborn-Fotinos, M. Reddington, U. Schwabe, and R. A. Olsson. Naunyn Schmiedebergs Arch Pharmacol 336(2):204-10 (August 1987)Lohse, M J Klotz, K N Lindenborn-Fotinos, J Reddington, M Schwabe, U Olsson, R A HL-30391/HL/NHLBI NIH HHS/United States Comparative Study In Vitro Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Germany, west Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 1987 Aug;3362:204-10..
2 years and 5 months ago
by pharmawuerz
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3',5'-Cyclic-AMP Activation/drug Adenylate Animals Assay Binding, Blood Cerebral Competitive Cortex/metabolism Cyclase/metabolism Enzyme Humans Isotope Labeling Myocardium/metabolism Phosphodiesterases/metabolism Platelets/enzymology Purinergic/*drug Radioligand Rats Xanthine Xanthines/*pharmacology effects Receptor
(0)
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Affinities of barbiturates for the GABA-receptor complex and A1 adenosine receptors: a possible explanation of their excitatory effects
M. J. Lohse, S. Boser, K. N. Klotz, and U. Schwabe. Naunyn Schmiedebergs Arch Pharmacol 336(2):211-7 (August 1987)Lohse, M J Boser, S Klotz, K N Schwabe, U In Vitro Research Support, Non-U.S. Gov't Germany, west Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 1987 Aug;3362:211-7..
M. J. Lohse, S. Boser, K. N. Klotz, and U. Schwabe. Naunyn Schmiedebergs Arch Pharmacol 336(2):211-7 (August 1987)Lohse, M J Boser, S Klotz, K N Schwabe, U In Vitro Research Support, Non-U.S. Gov't Germany, west Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 1987 Aug;3362:211-7..
2 years and 5 months ago
by pharmawuerz
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*Bicyclo Animals Barbiturates/*metabolism/pharmacology Bicyclo Binding, Brain/metabolism Competitive Compounds, Compounds/metabolism Diazepam/metabolism GABA-A/*metabolism/physiology Heterocyclic Male Methohexital/pharmacology Phenylisopropyladenosine/metabolism Purinergic/*metabolism/physiology Rats Strains Receptor Mice
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Characterization of the solubilized A1 adenosine receptor from rat brain membranes
K. N. Klotz, M. J. Lohse, and U. Schwabe. J Neurochem 46(5):1528-34 (May 1986)Klotz, K N Lohse, M J Schwabe, U Comparative Study Research Support, Non-U.S. Gov't United states Journal of neurochemistry J Neurochem. 1986 May;465:1528-34..
K. N. Klotz, M. J. Lohse, and U. Schwabe. J Neurochem 46(5):1528-34 (May 1986)Klotz, K N Lohse, M J Schwabe, U Comparative Study Research Support, Non-U.S. Gov't United states Journal of neurochemistry J Neurochem. 1986 May;465:1528-34..
2 years and 5 months ago
by pharmawuerz
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*Brain Animals Binding, Calcium/pharmacology Cations, Cell Chemistry Competitive Divalent GTP Guanosine Kinetics Magnesium/pharmacology Manganese/pharmacology Membrane/analysis Phenylisopropyladenosine/metabolism Phosphohydrolases/metabolism Purinergic Rats Surface/drug Triphosphate/pharmacology Xanthines/pharmacology effects/*metabolism Receptor
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Chemical modification of A1 adenosine receptors in rat brain membranes. Evidence for histidine in different domains of the ligand binding site
K. N. Klotz, M. J. Lohse, and U. Schwabe. J Biol Chem 263(33):17522-6 (November 1988)Klotz, K N Lohse, M J Schwabe, U Research Support, Non-U.S. Gov't United states The Journal of biological chemistry J Biol Chem. 1988 Nov 25;26333:17522-6..
K. N. Klotz, M. J. Lohse, and U. Schwabe. J Biol Chem 263(33):17522-6 (November 1988)Klotz, K N Lohse, M J Schwabe, U Research Support, Non-U.S. Gov't United states The Journal of biological chemistry J Biol Chem. 1988 Nov 25;26333:17522-6..
2 years and 5 months ago
by pharmawuerz
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& Adenosine/analogs Animals Assay Binding, Brain/*metabolism Cell Competitive Compounds/pharmacology Diethyl Ethylmaleimide/pharmacology Kinetics Membrane/metabolism Phenylmercury Purinergic/drug Pyrocarbonate/pharmacology Radioligand Rats Tetranitromethane/pharmacology derivatives/metabolism effects/*metabolism Receptor
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Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells
K. N. Klotz, J. Hessling, J. Hegler, C. Owman, B. Kull, B. B. Fredholm, and M. J. Lohse. Naunyn Schmiedebergs Arch Pharmacol 357(1):1-9 (January 1998)Klotz, K N Hessling, J Hegler, J Owman, C Kull, B Fredholm, B B Lohse, M J Comparative Study Research Support, Non-U.S. Gov't Germany Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;3571:1-9..
K. N. Klotz, J. Hessling, J. Hegler, C. Owman, B. Kull, B. B. Fredholm, and M. J. Lohse. Naunyn Schmiedebergs Arch Pharmacol 357(1):1-9 (January 1998)Klotz, K N Hessling, J Hegler, J Owman, C Kull, B Fredholm, B B Lohse, M J Comparative Study Research Support, Non-U.S. Gov't Germany Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;3571:1-9..
2 years and 5 months ago
by pharmawuerz
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& Adenosine-5'-(N-ethylcarboxamide)/pharmacology Adenosine/analogs Animals Base Binding, CHO Cells/*metabolism Competitive Composition Cricetinae Cyclase/metabolism Guanylate Humans P1/biosynthesis/*drug Phenethylamines/pharmacology Phenylisopropyladenosine/metabolism Purinergic Relationship Stereoisomerism Structure-Activity Transfection Xanthines/pharmacology derivatives/pharmacology effects/genetics Receptor
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Abolition of --CGP 12177-evoked cardiostimulation in double beta1/beta2-adrenoceptor knockout mice. Obligatory role of beta1-adrenoceptors for putative beta4-adrenoceptor pharmacology
A. J. Kaumann, S. Engelhardt, L. Hein, P. Molenaar, and M. Lohse. Naunyn Schmiedebergs Arch Pharmacol 363(1):87-93 (January 2001)Kaumann, A J Engelhardt, S Hein, L Molenaar, P Lohse, M Comparative Study In Vitro Research Support, Non-U.S. Gov't Germany Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 2001 Jan;3631:87-93..
A. J. Kaumann, S. Engelhardt, L. Hein, P. Molenaar, and M. Lohse. Naunyn Schmiedebergs Arch Pharmacol 363(1):87-93 (January 2001)Kaumann, A J Engelhardt, S Hein, L Molenaar, P Lohse, M Comparative Study In Vitro Research Support, Non-U.S. Gov't Germany Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 2001 Jan;3631:87-93..
2 years and 5 months ago
by pharmawuerz
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& 1-Methyl-3-isobutylxanthine/pharmacology Adrenergic Animals Atria/*drug Atrial Binding, Bucladesine/pharmacology Competitive/drug Contraction/drug Dose-Response Drug Female Function Genotype Heart Isoproterenol/pharmacology Knockout Male Membranes/drug Mice Myocardial Node/drug Pindolol/*analogs Propanolamines/metabolism/*pharmacology Relationship, Sinoatrial Tritium/diagnostic beta-1/genetics/physiology beta-2/genetics/physiology beta-Agonists/pharmacology beta-Antagonists/*pharmacology beta/drug derivatives/pharmacology effects effects/metabolism effects/physiology use Receptor
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Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells
C. Hoffmann, M. R. Leitz, S. Oberdorf-Maass, M. J. Lohse, and K. N. Klotz. Naunyn Schmiedebergs Arch Pharmacol 369(2):151-9 (February 2004)Hoffmann, C Leitz, M R Oberdorf-Maass, S Lohse, M J Klotz, K-N Comparative Study Research Support, Non-U.S. Gov't Germany Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;3692:151-9. Epub 2004 Jan 17..
C. Hoffmann, M. R. Leitz, S. Oberdorf-Maass, M. J. Lohse, and K. N. Klotz. Naunyn Schmiedebergs Arch Pharmacol 369(2):151-9 (February 2004)Hoffmann, C Leitz, M R Oberdorf-Maass, S Lohse, M J Klotz, K-N Comparative Study Research Support, Non-U.S. Gov't Germany Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;3692:151-9. Epub 2004 Jan 17..
2 years and 5 months ago
by pharmawuerz
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Adenylate Adrenergic Animals Assay Binding, CHO Competitive Cricetinae Cricetulus Cyclase/biosynthesis Humans Radioligand Transfection beta-Agonists/*pharmacology beta-Antagonists/*pharmacology beta/biosynthesis/classification/*metabolism Receptor Cell
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A1 adenosine receptors expressed in CHO-cells couple to adenylyl cyclase and to phospholipase C
S. Freund, M. Ungerer, and M. J. Lohse. Naunyn Schmiedebergs Arch Pharmacol 350(1):49-56 (July 1994)Freund, S Ungerer, M Lohse, M J Research Support, Non-U.S. Gov't Germany Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 1994 Jul;3501:49-56..
S. Freund, M. Ungerer, and M. J. Lohse. Naunyn Schmiedebergs Arch Pharmacol 350(1):49-56 (July 1994)Freund, S Ungerer, M Lohse, M J Research Support, Non-U.S. Gov't Germany Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 1994 Jul;3501:49-56..
2 years and 5 months ago
by pharmawuerz
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& Adenylate Animals Binding, Bordetella/pharmacology Brain/drug C CHO Cell Competitive Cricetinae Cricetulus Cyclase Cyclase/*metabolism Factors, Inositol Membrane/metabolism P1/agonists/antagonists Pertussis Phosphates/metabolism Phospholipases/*metabolism Proteins/metabolism Purinergic Rats Recombinant Signal Toxin Transduction Type Virulence Xanthines/metabolism/pharmacology effects/metabolism inhibitors/*metabolism Receptor
(0)
URLDOITeX
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors
G. Cristalli, A. Eleuteri, S. Vittori, R. Volpini, M. J. Lohse, and K. N. Klotz. J Med Chem 35(13):2363-8 (June 1992)Cristalli, G Eleuteri, A Vittori, S Volpini, R Lohse, M J Klotz, K N Research Support, Non-U.S. Gov't United states Journal of medicinal chemistry J Med Chem. 1992 Jun 26;3513:2363-8..
G. Cristalli, A. Eleuteri, S. Vittori, R. Volpini, M. J. Lohse, and K. N. Klotz. J Med Chem 35(13):2363-8 (June 1992)Cristalli, G Eleuteri, A Vittori, S Volpini, R Lohse, M J Klotz, K N Research Support, Non-U.S. Gov't United states Journal of medicinal chemistry J Med Chem. 1992 Jun 26;3513:2363-8..
2 years and 5 months ago
by pharmawuerz
2
& Adenosine-5'-(N-ethylcarboxamide) Adenosine/*analogs Adenylate Aggregation/drug Animals Assay Binding, Blood Brain Cell Chemistry Competitive Cultured Cyclase/metabolism Humans Membrane/chemistry Platelet Platelets/chemistry Purinergic/*drug Radioligand Rats derivatives/chemistry/metabolism/*pharmacology effects Receptor
(0)
URLDOITeX
Synthesis of new delta 2-isoxazoline derivatives and their pharmacological characterization as beta-adrenergic receptor antagonists
P. Conti, C. Dallanoce, M. De Amici, C. De Micheli, and K. N. Klotz. Bioorg Med Chem 6(4):401-8 (April 1998)Conti, P Dallanoce, C De Amici, M De Micheli, C Klotz, K N Research Support, Non-U.S. Gov't England Bioorganic \& medicinal chemistry Bioorg Med Chem. 1998 Apr;64:401-8..
P. Conti, C. Dallanoce, M. De Amici, C. De Micheli, and K. N. Klotz. Bioorg Med Chem 6(4):401-8 (April 1998)Conti, P Dallanoce, C De Amici, M De Micheli, C Klotz, K N Research Support, Non-U.S. Gov't England Bioorganic \& medicinal chemistry Bioorg Med Chem. 1998 Apr;64:401-8..
2 years and 5 months ago
by pharmawuerz
2
& Adenylate Adrenergic Animals Assay Binding, CHO Chromatography, Competitive Cricetinae Cultured Cyclase/metabolism Glioma Humans Isoxazoles/*chemical Layer Magnetic Pindolol/analogs Propanolamines/metabolism Radioligand Rats Resonance Spectroscopy Thin Tumor beta-1/*antagonists beta-2/*antagonists beta-Agonists/*chemical beta-Antagonists/*chemical derivatives/metabolism inhibitors/metabolism synthesis/metabolism Receptor Cell
(0)
URLDOITeX
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