In much of the world (but not in the U.S.,) drug-coated stents are avoided by cardiologists because of their high cost. To compensate for the inability to use these stents, many cardiologists outside of the U.S. have taken to administering sirolimus (also
Electron Beam CT, or EBCT scans (formerly called ultrafast CT scans) are useful in detecting the presence of calcium deposits in the lining of the coronary arteries. The presence of calcium deposits is a strong indicator that coronary artery disease is al
Exposure to secondhand smoke leads to inflammation and oxidation, representing another pathophysiologic mechanism for the development of atherosclerosis.
Mind-boggling networks of cytokines and transcription factors have been invoked to explain the anemia of inflammation. Does it really have to be so complicated? Elevated hepcidin; defensive sequestering of serum ferritin (iron); direct cytokine disruption
commonly observed in patients with chronic infections, malignancy, trauma, and inflammatory disorders...inflammatory cytokine IL-6 induces production of hepcidin, an iron-regulatory hormone that may be responsible...
Today we're going to discuss the anemia of inflammation -- starting with its mechanisms, then looking at a fairly new genetic link between inflammation and anemia, and including how we can apply all of this to our patients.
Although in many cases the cause of anemia is not found, a primary deficiency of erythropoietin may be at fault in at least some of these cases since the response of erythropoietin to anemia may decrease in individuals over age 70. Conclusions: Anemia sh
The anti-inflammatory potential of an oral p38 MAPK inhibitor in humans in vivo suggests that p38 MAPK inhibitors may provide a new therapeutic option in the treatment of inflammatory diseases. Boehringer Ingelheim. 2002 Branger J, et al
Anti-Inflammatory Effects of Pioglitazone and/or Simvastatin in High Cardiovascular Risk Patients With Elevated High Sensitivity C-Reactive Protein The PIOSTAT Study
Aging may be an intrinsic factor in the development of anemia, possibly through the age-related dysregulation of certain proinflammatory cytokines such as interleukin-6 (IL-6)...Increased IL-6 and other proinflammatory cytokines directly inhibit erythropo
Baseline values of C reactive protein, serum amyloid A protein, leucocyte count, and serum albumin were associated with one another as well as with future risk of coronary heart disease.
Over 20 large-scale prospective studies show that the inflammatory biomarker high-sensitivity C-reactive protein (hsCRP) is an independent predictor of future cardiovascular events
Researchers say circulating mononuclear cells (the largest type of white blood cell) and lymphocytes, exist in a proinflammatory state in obese persons known to be at increased risk of developing heart disease, diabetes, or both.
Overweight men and women assigned to drink fructose-sweetened beverages as 25% of their energy intake developed atherogenic lipid profiles in just two weeks; unlike glucose, fructose promotedatherogenic lioproprotein phenotypes and glucose intolerance/ins
A high-glycemic diet w/high blood insulin, overabundant omega-6 from processed vegetable oils, high-heat cooking of proteins (leading to glycation)...all lead to increased inflammatory cytokines.
Chronic inflammation is also involved in diseases as diverse as atherosclerosis, cancer, heart valve dysfunction, obesity, diabetes, congestive heart failure, digestive system diseases, and Alzheimer's disease...The New England Journal of Medicine publish
Chronic inflammation is also involved in diseases as diverse as atherosclerosis, cancer, heart valve dysfunction, obesity, diabetes, congestive heart failure, digestive system diseases, and Alzheimer's disease...The New England Journal of Medicine publish
Millions of Americans are deficient in the vital digestive enzyme called D6D (delta-6 desaturase) required to convert flax oil into EPA and GLA, the two nutrients that fight inflammation. Unlike flax seed oil, borage and fish oils do not require that prob
Underlying the body’s healing response is a process by which tissues inflame. Chronic inflammation, if left unchecked, can devastate the body’s tissues, especially in the vascular and nervous systems. Numerous natural products help control the inflamm
Doctors are trying to understand, for example, why some individuals suffer heart attacks even though they do not have major heart blockages - and inflammation may be the answer. In fact, many chronic cardiovascular diseases suffered by millions of America
The roles and functions of cytokines are confusing and still being sorted out. Over three dozen have been identified with more being discovered each day.