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Sunitinib efficacy against advanced renal cell carcinoma
R. J. Motzer, M. D. Michaelson, J. Rosenberg, R. M. Bukowski, B. D. Curti, D. J. George, G. R. Hudes, B. G. Redman, K. A. Margolin, and G. Wilding J.Urol. 178(5):1883-1887 (2007)
to & Administration Adult Aged Agents Antineoplastic Carcinoma Cell Disease Disease-Free Female Follow-Up Humans Indoles Kidney Laboratories Male Method Middle Neoplasm Neoplasms Oral Outcome Progression Pyrroles Rate Renal Research Retrospective Single-Blind Staging States Studies Survival Treatment Tyrosine United administration dosage drug epidemiology methods mortality pathology response therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib
T. F. Chu, M. A. Rupnick, R. Kerkela, S. M. Dallabrida, D. Zurakowski, L. Nguyen, K. Woulfe, E. Pravda, F. Cassiola, J. Desai, S. George, J. A. Morgan, D. M. Harris, N. S. Ismail, J. H. Chen, F. J. Schoen, A. D. van den Abbeele, G. D. Demetri, T. Force, and M. H. Chen Lancet 370(9604):2011-2019 (2007)
to & Aged Agents Animals Antineoplastic Arteries Artery Blood Carcinoma Coronary Disease Failure Female Gastrointestinal Heart Humans Hypertension Indoles Kinase Kinases Male Mice Middle Multicenter Pressure Protein-Tyrosine Pyrroles Rats Research Retrospective Safety Stroke Stromal Studies Topic Tumors Tyrosine Volume adverse antagonists as blood chemically drug effects induced inhibitors methods therapeutic therapy toxicity use by kanefendt on Feb 5, 2010, 11:28 AM
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Surrogate predictive biomarkers for response to anti-EGFR agents: state of the art and challenges
F. Cappuzzo, L. Toschi, G. Finocchiaro, C. Ligorio, and A. Santoro Int.J.Biol.Markers 22(1 Suppl 4):S10-S23 (2007)
to & Antibodies Biological Carcinoma Dosage Drug Epidermal Factor Gene Growth Human Humans Immunohistochemistry Inhibitors Kinase Kinases Lung Markers Monoclonal Mutation Neoplasm Neoplasms Non-Small-Cell Phosphoproteins Predictive Protein Protein-Tyrosine Proteins Proto-Oncogene Quinazolines Receptor Resistance Tests Tyrosine Value analysis antagonists c-akt drug effects erbB-2 erbB-3 genetics identify inhibitors of protein response therapeutic therapy use by kanefendt and 1 other user on Feb 5, 2010, 11:28 AM
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Severe cardiomyopathy in a patient with renal cell carcinoma after treatment with the novel tyrosine kinase inhibitor sunitinib
E. Chorianopoulos, D. Jager, H. A. Katus, and N. Frey Clin.Res.Cardiol. 96(11):829-830 (2007)
to & Aged Agents Angiogenesis Antineoplastic Carcinoma Cardiomyopathies Cell Dysfunction Echocardiography Female Humans Illness Index Indoles Inhibitors Kidney Kinase Kinases Left Neoplasms Protein-Tyrosine Pyrroles Renal Severity Tyrosine Ventricular adverse antagonists chemically contraindications drug effects induced inhibitors of therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins
Samuel Deprimo, Carlo Bello, John Smeraglia, Charles Baum, Dominic Spinella, Brian Rini, M. Dror Michaelson, and Robert Motzer Journal of Translational Medicine 5(1):32 (2007)
to Carcinoma Disease Placenta Progression Proteins Tyrosine analysis protein response therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Molecular basis for sunitinib efficacy and future clinical development
S. Faivre, G. Demetri, W. Sargent, and E. Raymond Nat.Rev.Drug Discov. 6(9):734-745 (2007)
to & A Angiogenesis Animals Carcinoma Clinical Design Drug Endothelial Factor France Growth Humans Indoles Inhibitors Kinase Kinases Neoplasm Neoplasms Protein-Tyrosine Pyrroles Receptors Resistance Topic Trials Tyrosine Vascular adverse antagonists as biosynthesis blood drug effects enzymology inhibitors metabolism pharmacology response supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular Endothelial Growth Factor-Targeted Therapy in Renal Cell Carcinoma: Current Status and Future Directions
Brian I. Rini Clin Cancer Res 13(4):1098-1106 (2007)
to Antibodies Carcinoma Patient Selection Tyrosine therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Monoclonal antibodies against epidermal growth factor receptor in advanced colorectal carcinoma: clinical efficacy and markers of sensitivity
E. Carcereny, and J. Maurel Rev.Recent Clin.Trials 1(2):113-118 (2006)
to & Animals Antibodies Biomarkers Carcinoma Colorectal Drug Epidermal Europe Factor Factors Growth Humans Immunologic Ligands Medical Monoclonal Mutation Neoplasm Neoplasms Oncology Pharmacological Phosphorylation Prognosis Receptor Resistance Tyrosine antagonists genetics inhibitors pharmacology response therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Prognostic markers and new, innovative treatments in renal cell carcinoma
C. C. Secasan Saudi.J.Kidney Dis.Transpl. 20(3):355-361 (2009)
to Carcinoma Research Tyrosine response surgery by kanefendt on Feb 5, 2010, 11:28 AM
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Home blood-pressure monitoring in patients receiving sunitinib
M. Azizi, A. Chedid, and S. Oudard N.Engl.J.Med. 358(1):95-97 (2008)
to Agents Ambulatory Angiogenesis Antineoplastic Blood Carcinoma Cell Heart Home Humans Hypertension Indoles Inhibitors Kidney Kinase Kinases Monitoring Neoplasms Nursing Pressure Protein-Tyrosine Pyrroles Rate Receptor Renal Telemedicine adverse chemically diagnosis drug effects induced therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
H. J. Burstein, A. D. Elias, H. S. Rugo, M. A. Cobleigh, A. C. Wolff, P. D. Eisenberg, M. Lehman, B. J. Adams, C. L. Bello, S. E. Deprimo, C. M. Baum, and K. D. Miller J Clin Oncol 26(11):1810-1816 (2008)
to & Administration Adult Aged Agents Anthracyclines Antineoplastic Biological Breast Bridged Carcinoma Chemotherapy Combined Compounds Diseases Drug Fatigue Female Gastrointestinal Growth Hematologic Humans Indoles Inflammation Kinase Kinases Markers Middle Neoplasms Oral Plasma Protein-Tyrosine Protocols Pyrroles Rate Schedule Survival Taxoids Tumor Tyrosine administration adverse analysis antagonists blood chemically classification dosage drug effects induced inhibitors methods mortality response secondary therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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EGFR FISH versus mutation: different tests, different end-points
F. Cappuzzo Lung Cancer 60(2):160-165 (2008)
to & Analysis Carcinoma Clinical DNA Drug Epidermal Factor Fluorescence Growth Humans Hybridization In Inhibitors Kinase Lung Mutation Mutational Neoplasm Neoplasms Non-Small-Cell Patient Population Protein Receptor Resistance Selection Situ Topic Trials Tyrosine analysis antagonists as drug genetics identify inhibitors protein response therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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High VEGFR-3-positive circulating lymphatic/vascular endothelial progenitor cell level is associated with poor prognosis in human small cell lung cancer
K. Bogos, F. Renyi-Vamos, J. Dobos, I. Kenessey, J. Tovari, J. Timar, J. Strausz, G. Ostoros, W. Klepetko, H. J. Ankersmit, G. Lang, M. A. Hoda, P. Nierlich, and B. Dome Clin.Cancer Res. 15(5):1741-1746 (2009)
to Adult Aged Antibodies Assay Bone C Capillaries Carcinoma Case-Control Cell Cells Cytometry Disease Endothelial Enzyme-Linked Factor Female Flow Follow-Up Growth Human Humans Immunosorbent Lung Lymphatic Male Marrow Metastasis Middle Neoplasms Population Prognosis Progression Rate Receptor-3 Research Small Stem Studies Survival Vascular Vessels blood cells metabolism pathology by kanefendt on Feb 5, 2010, 11:28 AM
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Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: results of a pharmacokinetic/pharmacodynamic meta-analysis
B. E. Houk, C. L. Bello, B. Poland, L. S. Rosen, G. D. Demetri, and R. J. Motzer Cancer Chemother.Pharmacol. (2009)
to Blood Carcinoma Fatigue Pressure Research adverse blood effects methods response by kanefendt on Feb 5, 2010, 11:28 AM
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Endothelial VEGFR-3 expression in colorectal carcinomas is associated with hematogenous metastasis
C. Jayasinghe, N. Simiantonaki, R. Michel-Schmidt, and C. J. Kirkpatrick Oncol.Rep. 22(5):1093-1100 (2009)
to Antibody Assay Blood Carcinoma Cell Cells Colon Colorectal Cytometry Endothelial Endothelium Enzyme-Linked Factor Flow Fluorescent Growth Human Humans Hypoxia Immunoenzyme Immunohistochemistry Immunosorbent Lymphatic Metastasis Neoplasm Neoplasms Neovascularization Pathologic Prognosis Receptor-3 Technique Techniques Vascular Vessels blood cells metabolism pathology protein supply by kanefendt on Feb 5, 2010, 11:28 AM
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Sunitinib treatment for patients with clear-cell metastatic renal cell carcinoma: clinical outcomes and plasma angiogenesis markers
L. F. Kontovinis, K. T. Papazisis, P. Touplikioti, C. Andreadis, D. Mouratidou, and A. H. Kortsaris BMC.Cancer (2009)
to Carcinoma Gastrointestinal Medical Oncology Plasma Population Stromal Tumors Tyrosine analysis methods protein response by kanefendt on Feb 5, 2010, 11:28 AM
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Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma
M. Schmidinger, C. C. Zielinski, U. M. Vogl, A. Bojic, M. Bojic, C. Schukro, M. Ruhsam, M. Hejna, and H. Schmidinger J.Clin.Oncol. 26(32):5204-5212 (2008)
to 80 Aged Arteries Artery Benzenesulfonates Biological Carcinoma Cardiovascular Cell Coronary Disease Diseases Echocardiography Electrocardiography Estimate Factors Failure Female Heart Humans Hypertension Indoles Inhibitors Kaplan-Meiers Kidney Kinase Male Markers Metastasis Middle Neoplasm Neoplasms Outcome Prospective Protein Pyridines Pyrroles Renal Research Risk Studies Time Treatment Tyrosine adverse and blood chemically diagnosis drug effects enzymology induced methods mortality over pathology protein therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Hypoxia-induced epithelial VEGF-C/VEGFR-3 upregulation in carcinoma cell lines
N. Simiantonaki, C. Jayasinghe, R. Michel-Schmidt, K. Peters, M. I. Hermanns, and C. J. Kirkpatrick Int.J.Oncol. 32(3):585-592 (2008)
to 1 Adenocarcinoma Autocrine Breast C Carcinoma Cell Colorectal Communication Endothelial Expression Factor Gene Growth Human Humans Hypoxia Hypoxia-Inducible Line Lung Neoplasms Neoplastic Oxygen Receptor-1 Receptor-2 Receptor-3 Regulation Subunit Survival Tumor Up-Regulation Vascular alpha cells genetics metabolism pathology physiology protein by kanefendt on Feb 5, 2010, 11:28 AM
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Phase I dose escalation study of telatinib BAY 57-9352 in patients with advanced solid tumours
D. Strumberg, B. Schultheis, I. A. Adamietz, O. Christensen, M. Buechert, J. Kraetzschmar, P. Rajagopalan, M. Ludwig, A. Frost, S. Steinbild, M. E. Scheulen, and K. Mross Br.J.Cancer 99(10):1579-1585 (2008)
to & 80 Adult Aged Agents Angiogenesis Antineoplastic Carcinoma Dose Female Growth Humans Hypertension Imaging Inhibitors Magnetic Male Maximum Medical Middle Neoplasms Oncology Plasma Pyridazines Pyridines RANGE Resonance Tolerated Tyrosine administration and blood dosage drug over response therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors
A. M. Petit, J. Rak, M. C. Hung, P. Rockwell, N. Goldstein, B. Fendly, and R. S. Kerbel Am.J.Pathol. 151(6):1523-1530 (1997)
to A Adenocarcinoma Animals Antibodies Breast Carcinoma Cell Cells Cultured Dose-Response Down-Regulation Drug Endothelial Epidermal Expression Factor Factors Gene Growth Human Humans Immunoenzyme Lymphokines Mice Monoclonal Neoplasm Neoplasms Neoplastic Neovascularization Neutralization Nude Oncogenes Pathologic Proliferation Receptor Regulation Relationship Research Signal Squamous Survival Techniques Tests Transduction Transplantation Tumor Tyrosine Vascular blood cells drug effects erbB-2 immunology metabolism pathology pharmacology physiology protein therapy by kanefendt on Feb 5, 2010, 11:28 AM
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