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Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage
N. Henke, R. Schmidt-Ullrich, R. Dechend, J. K. Park, F. Qadri, M. Wellner, M. Obst, V. Gross, R. Dietz, F. C. Luft, C. Scheidereit, and D. N. Muller Circ.Res. 101(3):268-276 (2007)
to & Adhesion Albuminuria Angiotensin Animals Atherosclerosis B Blood C57BL Cardiovascular Cell Cells Chain Chloride Cultured Dietary Diseases Endothelial Ester Expression Factor-alpha Fusion Gene Humans Hypertension I-kappa II III Inbred Inflammation Intercellular Kidney Methyl Mice Models Molecule-1 NF-kappa NG-Nitroarginine Necrosis Nephritis Nitric Organ Oxide Polymerase Pressure Proteins Reaction Receptor Recombinant Regulation Research Reverse Signal Sodium Specificity Synthase TIE-1 Transcriptase Transduction Transgenic Tumor Type Vascular antagonists biosynthesis blood cells complications control etiology genetics inhibitors metabolism physiology physiopathology prevention protein toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Surrogate predictive biomarkers for response to anti-EGFR agents: state of the art and challenges
F. Cappuzzo, L. Toschi, G. Finocchiaro, C. Ligorio, and A. Santoro Int.J.Biol.Markers 22(1 Suppl 4):S10-S23 (2007)
to & Antibodies Biological Carcinoma Dosage Drug Epidermal Factor Gene Growth Human Humans Immunohistochemistry Inhibitors Kinase Kinases Lung Markers Monoclonal Mutation Neoplasm Neoplasms Non-Small-Cell Phosphoproteins Predictive Protein Protein-Tyrosine Proteins Proto-Oncogene Quinazolines Receptor Resistance Tests Tyrosine Value analysis antagonists c-akt drug effects erbB-2 erbB-3 genetics identify inhibitors of protein response therapeutic therapy use by kanefendt and 1 other user on Feb 5, 2010, 11:28 AM
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Angiogenesis: an organizing principle for drug discovery?
J. Folkman Nat.Rev.Drug Discov. 6(4):273-286 (2007)
to Agents Angiogenesis Animals Antineoplastic Blood Endothelium Humans Inhibitors Neoplasms Neovascularization Pathologic Physiologic Platelets RANGE Research drug effects genetics pathology pharmacology physiology therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular endothelial growth factor-D and its receptor VEGFR-3: two novel independent prognostic markers in gastric adenocarcinoma
S. Juttner, C. Wissmann, T. Jons, M. Vieth, J. Hertel, S. Gretschel, P. M. Schlag, W. Kemmner, and M. Hocker J.Clin.Oncol. 24(2):228-240 (2006)
to 80 Adenocarcinoma Adult Aged Antibodies C Cell Chemistry D Disease-Free Endothelial Factor Growth Humans Immunohistochemistry Laboratories Line Lymphatic Messenger Metastasis Middle Neoplasms Prognosis RNA Receptor-3 Research Stomach Survival Tumor Vascular analysis and blood genetics identify methods mortality over supply by kanefendt on Feb 5, 2010, 11:28 AM
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Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
M. Shibuya, and L. Claesson-Welsh Exp.Cell Res. 312(5):549-560 (2006)
to Aging Animals Cell Cells Development Division Embryonic Endothelial Endothelium Factor Growth Human Humans Japan Ligands Lymphangiogenesis Lymphatic Lymphedema Neovascularization Pathologic Physiologic Placenta Receptor-1 Receptor-2 Research Signal System Transduction Tyrosine Vascular Vertebrates cells cytology genetics physiology physiopathology response by kanefendt on Feb 5, 2010, 11:28 AM
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Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway
I. Shiojima, and K. Walsh Genes Dev. 20(24):3347-3365 (2006)
to & Adaptation Animals Cardiac Cardiomegaly Cell Contraction Differentiation Diseases Failure Growth Heart Humans Hypertension Myocardial Myocytes Neovascularization Physiologic Physiological Proteins Proto-Oncogene Signal Sports Transduction c-akt cytology development embryology genetics growth metabolism pathology physiology physiopathology protein by kanefendt on Feb 5, 2010, 11:28 AM
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Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis
M. Shibuya J Biochem.Mol.Biol. 39(5):469-478 (2006)
to A Animals Atherosclerosis Cells Chemistry Development Dna Embryonic Endothelial Factor Female Growth Human Humans Inflammation Japan Metastasis Mice Neoplasm Neoplasms Neovascularization Pathologic Physiologic Pre-Eclampsia Pregnancy Proteins Receptor-1 Receptor-2 Research Signal Transduction Tyrosine Vascular Viral blood cells genetics metabolism physiology physiopathology protein response supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Monoclonal antibodies against epidermal growth factor receptor in advanced colorectal carcinoma: clinical efficacy and markers of sensitivity
E. Carcereny, and J. Maurel Rev.Recent Clin.Trials 1(2):113-118 (2006)
to & Animals Antibodies Biomarkers Carcinoma Colorectal Drug Epidermal Europe Factor Factors Growth Humans Immunologic Ligands Medical Monoclonal Mutation Neoplasm Neoplasms Oncology Pharmacological Phosphorylation Prognosis Receptor Resistance Tyrosine antagonists genetics inhibitors pharmacology response therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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EGFR FISH versus mutation: different tests, different end-points
F. Cappuzzo Lung Cancer 60(2):160-165 (2008)
to & Analysis Carcinoma Clinical DNA Drug Epidermal Factor Fluorescence Growth Humans Hybridization In Inhibitors Kinase Lung Mutation Mutational Neoplasm Neoplasms Non-Small-Cell Patient Population Protein Receptor Resistance Selection Situ Topic Trials Tyrosine analysis antagonists as drug genetics identify inhibitors protein response therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Angiogenesis induced by hVEGF165 gene controlled by hypoxic response elements in rabbit ischemia myocardium
H. Dong, Q. Wang, Y. Zhang, B. Jiang, X. Xu, and Z. Zhang Exp.Biol.Med.Maywood. 234(12):1417-1424 (2009)
to 1 A Actins Animals Antigens Blood CD31 Dependovirus Elements Endothelial Expression Factor Gene Genetic Growth Heart Human Humans Hypoxia-Inducible Immunohistochemistry Ischemia Myocardial Myocardium Neovascularization Physiologic Rabbits Regulation Research Response Subunit Therapy Transduction Vascular Vessels alpha biosynthesis blood genetics pathology protein response therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular endothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth
J. M. Ebos, C. R. Lee, E. Bogdanovic, J. Alami, Slyke P. Van, G. Francia, P. Xu, A. J. Mutsaers, D. J. Dumont, and R. S. Kerbel Cancer Res. 68(2):521-529 (2008)
to A Adenocarcinoma Adenoviridae Animals BALB Biological Burden C C57BL Cell Cells Cultured Disease Endothelial Experimental Factor Female Genetic Growth HT29 Heterologous Human Humans Inbred Male Mammary Markers Mice Neoplasm Neoplasms Progression Proliferation Prostatic Receptor-2 Research Solubility Transduction Transfection Transgenic Transplantation Tumor Tyrosine Vascular blood cells genetics metabolism methods pathology physiology protein by kanefendt on Feb 5, 2010, 11:28 AM
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Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100
B. P. Schneider, M. Wang, M. Radovich, G. W. Sledge, S. Badve, A. Thor, D. A. Flockhart, B. Hancock, N. Davidson, J. Gralow, M. Dickler, E. A. Perez, M. Cobleigh, T. Shenkier, S. Edgerton, and K. D. Miller J.Clin.Oncol. 26(28):4672-4678 (2008)
to & A Antibodies Antineoplastic Breast Chemotherapy Combined Dna Endothelial Factor Female Genotype Growth Haplotypes Hazards Humans Hypertension Models Monoclonal Neoplasms Nonparametric Nucleotide Paclitaxel Polymorphism Proportional Protocols Rate Receptor-2 Research Retrospective Single Statistics Studies Survival Vascular administration dosage drug genetics methods pathology therapeutic therapy toxicity use by kanefendt on Feb 5, 2010, 11:28 AM
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The cancer biomarker problem
C. L. Sawyers Nature 452(7187):548-552 (2008)
to Biological Human Humans Markers Neoplasms Pharmacogenetics Prognosis Research Tumor analysis classification diagnosis genetics metabolism therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
T. Tammela, G. Zarkada, E. Wallgard, A. Murtomaki, S. Suchting, M. Wirzenius, M. Waltari, M. Hellstrom, T. Schomber, R. Peltonen, C. Freitas, A. Duarte, H. Isoniemi, P. Laakkonen, G. Christofori, S. Yla-Herttuala, M. Shibuya, B. Pytowski, A. Eichmann, C. Betsholtz, and K. Alitalo Nature 454(7204):656-660 (2008)
to & Adult Angiogenesis Animals Antibodies BALB Blood C Cell Cells Dipeptides Down-Regulation Endothelial Endothelium Expression Factor Factors Female Gene Growth Humans Inbred Inhibitors Laboratories Ligands Line Lymphangiogenesis Mice Monoclonal Neoplasms Neoplastic Neovascularization Notch Pathologic Proliferation Receptor-3 Receptors Regulation Research Signal Transduction Transgenic Tumor Tyrosine Vascular Vessels antagonists blood cells drug effects genetics inhibitors metabolism pharmacology supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Hypoxia-induced epithelial VEGF-C/VEGFR-3 upregulation in carcinoma cell lines
N. Simiantonaki, C. Jayasinghe, R. Michel-Schmidt, K. Peters, M. I. Hermanns, and C. J. Kirkpatrick Int.J.Oncol. 32(3):585-592 (2008)
to 1 Adenocarcinoma Autocrine Breast C Carcinoma Cell Colorectal Communication Endothelial Expression Factor Gene Growth Human Humans Hypoxia Hypoxia-Inducible Line Lung Neoplasms Neoplastic Oxygen Receptor-1 Receptor-2 Receptor-3 Regulation Subunit Survival Tumor Up-Regulation Vascular alpha cells genetics metabolism pathology physiology protein by kanefendt on Feb 5, 2010, 11:28 AM
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VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling
S. Swendeman, K. Mendelson, G. Weskamp, K. Horiuchi, U. Deutsch, P. Scherle, A. Hooper, S. Rafii, and C. P. Blobel Circ.Res. 103(9):916-918 (2008)
to A ADAM Amyloid Animals Cells Cercopithecus Cos Endothelial Extracellular Factor Factor-alpha Factors Fibroblasts Fusion Growth Human Humans Kinases Knockout MAP Membrane Mice Necrosis Neuropilin-1 Phosphorylation Precursor Protein Proteins Receptor-2 Recombinant Research Secretases Signal Signal-Regulated Swine Time Transduction Transfection Tumor Vascular aethiops cells deficiency enzymology genetics metabolism protein surgery by kanefendt on Feb 5, 2010, 11:28 AM
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Molecular biology and pathology of lymphangiogenesis
T. Karpanen, and K. Alitalo Annu.Rev.Pathol. (2008)
to Animal Animals Biological Biology Developmental Endothelial Endothelium Expression Factors Gene Growth Humans Laboratories Lymphangiogenesis Lymphatic Lymphedema Markers Mice Models Molecular Regulation Research System Vascular Vessels cytology genetics metabolism methods pathology by kanefendt on Feb 5, 2010, 11:28 AM
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Expression of vascular endothelial growth factor-C and its receptor in osteosarcomas
H. R. Park, K. Min, H. S. Kim, W. W. Jung, and Y. K. Park Pathol.Res.Pract. 204(8):575-582 (2008)
to Adolescent Adult Aged Bone C Cell Chain Child Cytoplasm D Endothelial Expression Factor Female Gene Growth Human Humans Immunohistochemistry Line Lymphatic Male Messenger Metastasis Middle Neoplasm Neoplasms Neoplastic Osteosarcoma Polymerase RNA Reaction Receptor-3 Regulation Research Up-Regulation Vascular Vessels cells genetics metabolism pathology protein by kanefendt on Feb 5, 2010, 11:28 AM
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Clinical usefulness of EGFR gene copy number as a predictive marker in colorectal cancer patients treated with cetuximab: a fluorescent in situ hybridization study
N. Personeni, S. Fieuws, H. Piessevaux, Hertogh G. De, Schutter J. De, B. Biesmans, Roock W. De, A. Capoen, M. biec Rychter, J. L. van Laethem, M. Peeters, Y. Humblet, Cutsem E. Van, and S. Tejpar Clin.Cancer Res. 14(18):5869-5876 (2008)
to 80 Adult Aged Antibodies Colorectal Disease-Free Dosage Female Fluorescence Gene Genes Genetic Humans Hybridization In Male Markers Middle Monoclonal Mutation Neoplasms Prognosis Research Situ Survival analysis and drug erbB-1 genetics over response therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors
T. V. Petrova, P. Bono, W. Holnthoner, J. Chesnes, B. Pytowski, H. Sihto, P. Laakkonen, P. Heikkila, H. Joensuu, and K. Alitalo Cancer Cell 13(6):554-556 (2008)
to Antibodies Antibody Blood Blotting Cell Cells Chain Chemistry Cytometry Endothelial Factor Flow Growth Humans Immunohistochemistry Line Lymphatic Messenger Neoplasms Northern Polymerase RNA Reaction Receptor-3 Reproducibility Results Reverse Separation Specificity Transcriptase Tumor Vascular Vessels Western analysis blood genetics immunology methods of pathology supply by kanefendt on Feb 5, 2010, 11:28 AM
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