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The biology of epidermal growth factor receptor and its value as a prognostic/predictive factor
A. P. Dei Tos Int.J.Biol.Markers 22(1 Suppl 4):S3-S9 (2007)
to Antibodies Biological Epidermal Expression Factor Gene Growth Human Humans Immunohistochemistry Markers Monoclonal Neoplasms Neoplastic Prognosis Receptor Regulation Tyrosine analysis drug effects etiology identify pathology physiology response therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Surrogate biomarkers in evaluating response to anti-angiogenic agents: focus on sunitinib
S. E. Deprimo, and C. Bello Ann.Oncol (2007)
to Angiogenesis Biological Cells Endothelial Growth Humans Indoles Inhibitors Laboratories Markers Neoplasms Neovascularization Pathologic Proteins Pyrroles Research Tumor blood cells diagnosis drug effects metabolism methods pathology pharmacology protein response supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Molecular and cellular biomarkers for angiogenesis in clinical oncology
F. Bertolini, P. Mancuso, Y. Shaked, and R. S. Kerbel Drug Discov.Today 12(19-20):806-812 (2007)
to Angiogenesis Antigens Biological Cells Endothelial Humans Inhibitors Markers Microcirculation Neoplasms Neovascularization Pathologic Research Tumor blood cells diagnosis drug metabolism pathology pharmacology supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Surrogate predictive biomarkers for response to anti-EGFR agents: state of the art and challenges
F. Cappuzzo, L. Toschi, G. Finocchiaro, C. Ligorio, and A. Santoro Int.J.Biol.Markers 22(1 Suppl 4):S10-S23 (2007)
to & Antibodies Biological Carcinoma Dosage Drug Epidermal Factor Gene Growth Human Humans Immunohistochemistry Inhibitors Kinase Kinases Lung Markers Monoclonal Mutation Neoplasm Neoplasms Non-Small-Cell Phosphoproteins Predictive Protein Protein-Tyrosine Proteins Proto-Oncogene Quinazolines Receptor Resistance Tests Tyrosine Value analysis antagonists c-akt drug effects erbB-2 erbB-3 genetics identify inhibitors of protein response therapeutic therapy use by kanefendt and 1 other user on Feb 5, 2010, 11:28 AM
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Fit-for-purpose method development and validation for successful biomarker measurement
J. W. Lee, V. Devanarayan, Y. C. Barrett, R. Weiner, J. Allinson, S. Fountain, S. Keller, I. Weinryb, M. Green, L. Duan, J. A. Rogers, R. Millham, P. J. O'Brien, J. Sailstad, M. Khan, C. Ray, and J. A. Wagner Pharm.Res. 23(2):312-328 (2006)
to Approval Biological Calibration Chemistry Control Data Design Drug Interpretation Markers Models Quality Reproducibility Research Results Statistical Terminology Topic analysis as of by kanefendt on Feb 5, 2010, 11:28 AM
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Measurement of plasma levels of vascular endothelial growth factor in prostate cancer patients: relationship with clinical stage, Gleason score, prostate volume, and serum prostate-specific antigen
J. L. Duque, K. R. Loughlin, R. M. Adam, P. Kantoff, E. Mazzucchi, and M. R. Freeman Clinics. 61(5):401-408 (2006)
to 80 A Adult Age Aged Antigen Biological Case-Control Distribution Endothelial Factor Growth Humans Immunoassay Male Markers Middle Neoplasm Neoplasms Nonparametric Organ Population Prognosis Prostate Prostate-Specific Prostatic Retrospective Size Staging Statistics Studies Tumor Vascular and blood methods over pathology physiology by kanefendt on Feb 5, 2010, 11:28 AM
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Effects of aspirin on intra-platelet vascular endothelial growth factor, angiopoietin-1, and p-selectin levels in hypertensive patients
S. Nadar, A. D. Blann, and G. Y. Lip Am.J.Hypertens. 19(9):970-977 (2006)
to A Activation Aged Aggregation Angiopoietin-1 Aspirin Biological Blood Case-Control Count Cyclooxygenase Endothelial England Factor Female Follow-Up Growth Humans Hypertension Immunoassay Inhibitors Longitudinal Male Markers Middle Outcome P-Selectin Platelet Platelets Pressure Research Studies Thrombosis Treatment Vascular blood drug effects metabolism methods pharmacology physiopathology therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Circulating VEGF reduction, response and outcome in advanced colorectal cancer patients treated with cetuximab plus irinotecan
B. Vincenzi, D. Santini, A. Russo, M. Gavasci, F. Battistoni, G. Dicuonzo, L. Rocci, V. M. Rosaria, N. Gebbia, and G. Tonini Pharmacogenomics. 8(4):319-327 (2007)
to & A Adult Aged Antibodies Antineoplastic Biological Camptothecin Chemotherapy Colorectal Combined Disease Endothelial Factor Female Growth Humans Male Markers Medical Middle Monoclonal Neoplasms Oncology Outcome Progression Prospective Protocols Rate Studies Survival Treatment Tumor Vascular administration analogs antagonists blood derivatives dosage drug inhibitors methods mortality response therapeutic therapy trends use by kanefendt on Feb 5, 2010, 11:28 AM
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Soluble angiogenesis markers in gastric tumor patients
P. Mysliwiec, K. Pawlak, R. Bandurski, and B. Kedra Folia Histochem.Cytobiol. 47(1):81-86 (2009)
to A Adult Aged Antigens Biological CD Care Case-Control Cell Endothelial Factor Female Growth Human Humans Male Markers Middle Neoplasms Neovascularization Pathologic Plasma Preoperative Receptor-2 Receptors Solubility Stomach Studies Surface Tumor Vascular blood metabolism protein supply surgery by kanefendt on Feb 5, 2010, 11:28 AM
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Validation of analytic methods for biomarkers used in drug development
C. H. Chau, O. Rixe, H. McLeod, and W. D. Figg Clin.Cancer Res. 14(19):5967-5976 (2008)
to Agents Animals Antineoplastic Biological Biomarkers Chemistry Design Drug Evaluation Genome Genomics Human Humans Markers Medical Mice Neoplasms Oncology Outcome Pharmaceutical Pharmacological Preclinical Research Treatment Tumor analysis drug metabolism methods pharmacology therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
H. J. Burstein, A. D. Elias, H. S. Rugo, M. A. Cobleigh, A. C. Wolff, P. D. Eisenberg, M. Lehman, B. J. Adams, C. L. Bello, S. E. Deprimo, C. M. Baum, and K. D. Miller J Clin Oncol 26(11):1810-1816 (2008)
to & Administration Adult Aged Agents Anthracyclines Antineoplastic Biological Breast Bridged Carcinoma Chemotherapy Combined Compounds Diseases Drug Fatigue Female Gastrointestinal Growth Hematologic Humans Indoles Inflammation Kinase Kinases Markers Middle Neoplasms Oral Plasma Protein-Tyrosine Protocols Pyrroles Rate Schedule Survival Taxoids Tumor Tyrosine administration adverse analysis antagonists blood chemically classification dosage drug effects induced inhibitors methods mortality response secondary therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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How well do angiogenesis inhibitors work? Biomarkers of response prove elusive
V. Brower J.Natl.Cancer Inst. 101(12):846-847 (2009)
to A Analysis Angiogenesis Animals Antibodies Benzenesulfonates Biological Cells Cytokines Disease-Free Endothelial Factor Growth Humans Indoles Inhibitors Markers Monoclonal Neoplasms Pyridines Pyrroles Survival Tumor Vascular blood drug effects metabolism mortality pathology pharmacology response supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-Kit, in patients with advanced or metastatic solid tumors
F. A. Eskens, N. Steeghs, J. Verweij, J. L. Bloem, O. Christensen, Doorn L. van, J. Ouwerkerk, M. J. Jonge, J. W. Nortier, J. Kraetzschmar, P. Rajagopalan, and H. Gelderblom J.Clin.Oncol. 27(25):4169-4176 (2009)
to & A Administration Adolescent Adult Aged Angiogenesis Biological Contrast Dose Dose-Response Drug Endothelial Factor Factors Fatigue Female Growth Human Humans Hypertension Imaging Inhibitors Kinase Magnetic Male Markers Maximum Media Medical Metastasis Middle Neoplasm Neoplasms Oncology Oral Outcome Pharmacokinetics Plasma Platelet-Derived Protein Proteins Proto-Oncogene Pyridazines Pyridines Receptor Receptor-2 Receptor-3 Relationship Research Resonance Safety Schedule Time Tolerated Treatment Tumor Tyrosine Vascular Young administration adverse antagonists beta blood c-kit diagnostic dosage drug effects enzymology inhibitors methods pathology protein response supply therapy toxicity use by kanefendt on Feb 5, 2010, 11:28 AM
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Antiangiogenesis research is booming, as questions and studies proliferate
V. Brower J.Natl.Cancer Inst. 101(11):780-781 (2009)
to & Administration Analysis Angiogenesis Antibodies Antineoplastic Biological Chemotherapy Colorectal Combined Controlled Drug Humans Inhibitors Markers Monoclonal Neoplasms Pericytes Protocols Randomized Research Schedule Survival Topic Trials Tumor administration analysis as blood dosage drug effects mortality supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Biomarkers of response and resistance to antiangiogenic therapy
R. K. Jain, D. G. Duda, C. G. Willett, D. V. Sahani, A. X. Zhu, J. S. Loeffler, T. T. Batchelor, and A. G. Sorensen Nat.Rev.Clin.Oncol. 6(6):327-338 (2009)
to & A Angiogenesis Biological Drug Endothelial Factor Growth Humans Hypertension Inhibitors Markers Neoplasm Neoplasms Neovascularization Pathologic Research Resistance Tumor Vascular antagonists blood control inhibitors metabolism prevention response supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular endothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth
J. M. Ebos, C. R. Lee, E. Bogdanovic, J. Alami, Slyke P. Van, G. Francia, P. Xu, A. J. Mutsaers, D. J. Dumont, and R. S. Kerbel Cancer Res. 68(2):521-529 (2008)
to A Adenocarcinoma Adenoviridae Animals BALB Biological Burden C C57BL Cell Cells Cultured Disease Endothelial Experimental Factor Female Genetic Growth HT29 Heterologous Human Humans Inbred Male Mammary Markers Mice Neoplasm Neoplasms Progression Proliferation Prostatic Receptor-2 Research Solubility Transduction Transfection Transgenic Transplantation Tumor Tyrosine Vascular blood cells genetics metabolism methods pathology physiology protein by kanefendt on Feb 5, 2010, 11:28 AM
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Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma
M. Schmidinger, C. C. Zielinski, U. M. Vogl, A. Bojic, M. Bojic, C. Schukro, M. Ruhsam, M. Hejna, and H. Schmidinger J.Clin.Oncol. 26(32):5204-5212 (2008)
to 80 Aged Arteries Artery Benzenesulfonates Biological Carcinoma Cardiovascular Cell Coronary Disease Diseases Echocardiography Electrocardiography Estimate Factors Failure Female Heart Humans Hypertension Indoles Inhibitors Kaplan-Meiers Kidney Kinase Male Markers Metastasis Middle Neoplasm Neoplasms Outcome Prospective Protein Pyridines Pyrroles Renal Research Risk Studies Time Treatment Tyrosine adverse and blood chemically diagnosis drug effects enzymology induced methods mortality over pathology protein therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Biomarkers of angiogenesis for the development of antiangiogenic therapies in oncology: tools or decorations?
C. Sessa, A. Guibal, Conte G. Del, and C. Ruegg Nat.Clin.Pract.Oncol. 5(7):378-391 (2008)
to Angiogenesis Antibodies Benzenesulfonates Biological Clinical Humans Indoles Inhibitors Markers Monoclonal Neoplasms Neovascularization Pathologic Pyridines Pyrroles Research Topic Trials Tumor as drug metabolism therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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The cancer biomarker problem
C. L. Sawyers Nature 452(7187):548-552 (2008)
to Biological Human Humans Markers Neoplasms Pharmacogenetics Prognosis Research Tumor analysis classification diagnosis genetics metabolism therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?
T. D. Tsirlis, G. Papastratis, K. Masselou, C. Tsigris, A. Papachristodoulou, A. Kostakis, and N. I. Nikiteas World J.Gastroenterol. 14(17):2691-2701 (2008)
to Biological C Chain Colorectal D Endothelial Esophageal Factor Gastrointestinal Growth Human Humans Immunohistochemistry Inflammation Ligands Lymphangiogenesis Lymphatic Markers Metastasis Neoplasm Neoplasms Polymerase Predictive Prognosis Reaction Receptor-3 Staging Stomach System Tests Tumor Value Vascular Vessels blood metabolism mortality of pathology physiopathology surgery by kanefendt on Feb 5, 2010, 11:28 AM
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