Men older than 50 with androgen deficiency are at a greater risk for all-cause mortality than their peers with age-appropriate testosterone, reported investigators here.
Doctors are trying to understand, for example, why some individuals suffer heart attacks even though they do not have major heart blockages - and inflammation may be the answer. In fact, many chronic cardiovascular diseases suffered by millions of America
Patients with cancer-related anaemia generally have a poor prognosis. Evidence suggests that an effective erythropoietic protein (epoetin)-mediated haemoglobin (Hb) response provides marked improvement in quality of life (QoL)...the use of an agent which
Evidence emerged from studies in mice that hepcidin, a small peptide hormone exclusively produced in the liver in response to inflammation, could completely or nearly completely shut down normal iron hemostasis.
Aging may be an intrinsic factor in the development of anemia, possibly through the age-related dysregulation of certain proinflammatory cytokines such as interleukin-6 (IL-6)...Increased IL-6 and other proinflammatory cytokines directly inhibit erythropo
Mind-boggling networks of cytokines and transcription factors have been invoked to explain the anemia of inflammation. Does it really have to be so complicated? Elevated hepcidin; defensive sequestering of serum ferritin (iron); direct cytokine disruption
Today we're going to discuss the anemia of inflammation -- starting with its mechanisms, then looking at a fairly new genetic link between inflammation and anemia, and including how we can apply all of this to our patients.
How does hepcidin promote anemia of inflammation? "When you have some sort of stimulation of hepatocytes, they make more hepcidin, which causes internalization and destruction of ferroportin, stopping any further absorption of iron," Dr. Rivera explained.
commonly observed in patients with chronic infections, malignancy, trauma, and inflammatory disorders...inflammatory cytokine IL-6 induces production of hepcidin, an iron-regulatory hormone that may be responsible...
Chronic inflammation appears to contribute to tumor progression by establishing a milieu conducive to development of different cancers at all three stages of tumor development: initiation, progression and metastasis, inducing the release of a variety of c
A nonspecific immune reaction inducing a syndrome profile of fever, pain, anxiety, depression, reclusivity, anorexia, stress hormones, triggered by signals in the brain’s hypothalamus; body’s attempt to produce & preserve energy; cells secrete proinfl
Although in many cases the cause of anemia is not found, a primary deficiency of erythropoietin may be at fault in at least some of these cases since the response of erythropoietin to anemia may decrease in individuals over age 70. Conclusions: Anemia sh
Pathophysiology of systemic and chronic inflammatory imbalances in the body, inflammatory cytokines and their contribution to chronic diseases, clinical nutrition...
The roles and functions of cytokines are confusing and still being sorted out. Over three dozen have been identified with more being discovered each day.
Pro-inflammatory eicosanoids and cytokines are produced from arachidonic acid, and omega-3s have been shown to inhibit arachidonic acid metabolism, hence less pro-inflammatory synthesis. Understand how to use fish oils to prevent chronic disease.
Pro-inflammatory eicosanoids and cytokines are produced from arachidonic acid, and omega-3s have been shown to inhibit arachidonic acid metabolism, hence less pro-inflammatory synthesis. Understand how to use fish oils to prevent chronic disease.
Chronic inflammation is also involved in diseases as diverse as atherosclerosis, cancer, heart valve dysfunction, obesity, diabetes, congestive heart failure, digestive system diseases, and Alzheimer's disease...The New England Journal of Medicine publish
Chronic inflammation is also involved in diseases as diverse as atherosclerosis, cancer, heart valve dysfunction, obesity, diabetes, congestive heart failure, digestive system diseases, and Alzheimer's disease...The New England Journal of Medicine publish
Over the past several years, medicine has started to recognise the fundamental role of inflammation in nearly every disease process. Researchers and physicians have been redefining heart disease, Alzheimer’s, and even diabetes and obesity as inflammator
Over the past several years, medicine has started to recognise the fundamental role of inflammation in nearly every disease process. Researchers and physicians have been redefining heart disease, Alzheimer’s, and even diabetes and obesity as inflammator