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Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization
D. Fukumura, and R. K. Jain Microvasc.Res. 74(2-3):72-84 (2007)
to & Angiogenesis Animals Blood Endothelial Factors Growth Humans Inhibitors Laboratories Neoplasms Neovascularization Pathologic Research Vascular Vessels antagonists blood cells drug inhibitors pathology supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Monoclonal antibodies against epidermal growth factor receptor in advanced colorectal carcinoma: clinical efficacy and markers of sensitivity
E. Carcereny, and J. Maurel Rev.Recent Clin.Trials 1(2):113-118 (2006)
to & Animals Antibodies Biomarkers Carcinoma Colorectal Drug Epidermal Europe Factor Factors Growth Humans Immunologic Ligands Medical Monoclonal Mutation Neoplasm Neoplasms Oncology Pharmacological Phosphorylation Prognosis Receptor Resistance Tyrosine antagonists genetics inhibitors pharmacology response therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-Kit, in patients with advanced or metastatic solid tumors
F. A. Eskens, N. Steeghs, J. Verweij, J. L. Bloem, O. Christensen, Doorn L. van, J. Ouwerkerk, M. J. Jonge, J. W. Nortier, J. Kraetzschmar, P. Rajagopalan, and H. Gelderblom J.Clin.Oncol. 27(25):4169-4176 (2009)
to & A Administration Adolescent Adult Aged Angiogenesis Biological Contrast Dose Dose-Response Drug Endothelial Factor Factors Fatigue Female Growth Human Humans Hypertension Imaging Inhibitors Kinase Magnetic Male Markers Maximum Media Medical Metastasis Middle Neoplasm Neoplasms Oncology Oral Outcome Pharmacokinetics Plasma Platelet-Derived Protein Proteins Proto-Oncogene Pyridazines Pyridines Receptor Receptor-2 Receptor-3 Relationship Research Resonance Safety Schedule Time Tolerated Treatment Tumor Tyrosine Vascular Young administration adverse antagonists beta blood c-kit diagnostic dosage drug effects enzymology inhibitors methods pathology protein response supply therapy toxicity use by kanefendt on Feb 5, 2010, 11:28 AM
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Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma
M. Schmidinger, C. C. Zielinski, U. M. Vogl, A. Bojic, M. Bojic, C. Schukro, M. Ruhsam, M. Hejna, and H. Schmidinger J.Clin.Oncol. 26(32):5204-5212 (2008)
to 80 Aged Arteries Artery Benzenesulfonates Biological Carcinoma Cardiovascular Cell Coronary Disease Diseases Echocardiography Electrocardiography Estimate Factors Failure Female Heart Humans Hypertension Indoles Inhibitors Kaplan-Meiers Kidney Kinase Male Markers Metastasis Middle Neoplasm Neoplasms Outcome Prospective Protein Pyridines Pyrroles Renal Research Risk Studies Time Treatment Tyrosine adverse and blood chemically diagnosis drug effects enzymology induced methods mortality over pathology protein therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
T. Tammela, G. Zarkada, E. Wallgard, A. Murtomaki, S. Suchting, M. Wirzenius, M. Waltari, M. Hellstrom, T. Schomber, R. Peltonen, C. Freitas, A. Duarte, H. Isoniemi, P. Laakkonen, G. Christofori, S. Yla-Herttuala, M. Shibuya, B. Pytowski, A. Eichmann, C. Betsholtz, and K. Alitalo Nature 454(7204):656-660 (2008)
to & Adult Angiogenesis Animals Antibodies BALB Blood C Cell Cells Dipeptides Down-Regulation Endothelial Endothelium Expression Factor Factors Female Gene Growth Humans Inbred Inhibitors Laboratories Ligands Line Lymphangiogenesis Mice Monoclonal Neoplasms Neoplastic Neovascularization Notch Pathologic Proliferation Receptor-3 Receptors Regulation Research Signal Transduction Transgenic Tumor Tyrosine Vascular Vessels antagonists blood cells drug effects genetics inhibitors metabolism pharmacology supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling
S. Swendeman, K. Mendelson, G. Weskamp, K. Horiuchi, U. Deutsch, P. Scherle, A. Hooper, S. Rafii, and C. P. Blobel Circ.Res. 103(9):916-918 (2008)
to A ADAM Amyloid Animals Cells Cercopithecus Cos Endothelial Extracellular Factor Factor-alpha Factors Fibroblasts Fusion Growth Human Humans Kinases Knockout MAP Membrane Mice Necrosis Neuropilin-1 Phosphorylation Precursor Protein Proteins Receptor-2 Recombinant Research Secretases Signal Signal-Regulated Swine Time Transduction Transfection Tumor Vascular aethiops cells deficiency enzymology genetics metabolism protein surgery by kanefendt on Feb 5, 2010, 11:28 AM
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Molecular biology and pathology of lymphangiogenesis
T. Karpanen, and K. Alitalo Annu.Rev.Pathol. (2008)
to Animal Animals Biological Biology Developmental Endothelial Endothelium Expression Factors Gene Growth Humans Laboratories Lymphangiogenesis Lymphatic Lymphedema Markers Mice Models Molecular Regulation Research System Vascular Vessels cytology genetics metabolism methods pathology by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular endothelial growth factor measured in platelet poor plasma allows optimal separation between cancer patients and volunteers: a key to study an angiogenic marker in vivo?
W. Wynendaele, R. Derua, M. F. Hoylaerts, A. Pawinski, E. Waelkens, E. A. Bruijn, R. Paridaens, W. Merlevede, and A. T. van Oosterom Ann.Oncol. 10(8):965-971 (1999)
to A Adult Aged Assay Biological Endothelial Enzyme-Linked Factor Factors Female Growth Humans Immunosorbent Lymphokines Male Markers Middle Neoplasms Neovascularization Nonparametric Pathologic RANGE Reference Research Sensitivity Specificity Statistics Tumor Values Vascular analysis and blood diagnosis methods by kanefendt on Feb 5, 2010, 11:28 AM
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Release of the angiogenic cytokine vascular endothelial growth factor VEGF from platelets: significance for VEGF measurements and cancer biology
R. E. Banks, M. A. Forbes, S. E. Kinsey, A. Stanley, E. Ingham, C. Walters, and P. J. Selby Br.J Cancer 77(6):956-964 (1998)
to A Acid Adult Aged Assay Biological Blood Bone Cells Citrates Collection Edetic Endothelial Enzyme-Linked Factor Factors Female Growth Healing Heparin Humans Immunohistochemistry Immunosorbent Indicators Lymphokines Male Markers Marrow Megakaryocytes Middle Platelets Reagents Reference Research Sensitivity Specificity Specimen Values Vascular Wound and biosynthesis blood cells cytology methods physiology by kanefendt on Feb 5, 2010, 11:28 AM
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Evidence for the existence of a novel pregnancy-associated soluble variant of the vascular endothelial growth factor receptor, Flt-1
R. E. Banks, M. A. Forbes, J. Searles, D. Pappin, B. Canas, D. Rahman, S. Kaufmann, C. E. Walters, A. Jackson, P. Eves, G. Linton, J. Keen, J. J. Walker, and P. J. Selby Mol Hum.Reprod. 4(4):377-386 (1998)
to & A Acid Amino Binding Blood Cells Chain Chemistry Data Endothelial Factor Factors Female Fetal Growth Human Humans Kinase Kinases Lymphokines Male Molecular Placenta Polymerase Pregnancy Protein Protein-Tyrosine Proteins Proto-Oncogene Reaction Receptor Receptor-1 Research Reverse Sequence Solubility Transcriptase Umbilical Vascular Veins Weight blood cells cytology identify isolation metabolism protein purification by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular endothelial growth factor governs endothelial nitric-oxide synthase expression via a KDR/Flk-1 receptor and a protein kinase C signaling pathway
B. Q. Shen, D. Y. Lee, and T. F. Zioncheck J.Biol.Chem. 274(46):33057-33063 (1999)
to & A Adrenal Animals Aorta C Cattle Cell Cells Cortex Cultured Endothelial Endothelium Enzyme Enzymologic Ester Expression Factor Factors Gene Growth II Inhibitors Kinase Kinases Line Lymphokines Methyl NG-Nitroarginine Nitric Oxide Penicillamine Pharmacokinetics Protein Protein-Tyrosine Proteins Receptor Receptors Recombinant Regulation Signal Substances Synthase Transduction Type Tyrosine Up-Regulation Vascular analogs cells derivatives drug effects metabolism pharmacology protein by kanefendt on Feb 5, 2010, 11:28 AM
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VEGFs, receptors and angiogenesis
T. Veikkola, and K. Alitalo Semin.Cancer Biol. 9(3):211-220 (1999)
to A Animals Blood Endothelial Factor Factors Growth Humans Kinase Kinases Laboratories Lymphokines Neoplasms Neovascularization Pathologic Physiologic Protein-Tyrosine Receptor Receptors Research Vascular Vessels blood etiology physiology supply by kanefendt on Feb 5, 2010, 11:28 AM
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Cardiovascular failure in mouse embryos deficient in VEGF receptor-3
D. J. Dumont, L. Jussila, J. Taipale, A. Lymboussaki, T. Mustonen, K. Pajusola, M. Breitman, and K. Alitalo Science 282(5390):946-949 (1998)
to Adult Animals Antigens Blood C CD31 Cardiovascular Cell Chemistry Development Embryo Embryonic Endothelial Endothelium Factor Factors Fetal Gene Growth Hematopoiesis Heterozygote Homozygote Hybridization Immunohistochemistry In Kinase Kinases Ligands Lymphatic Mammalian Mice Neovascularization Physiologic Protein-Tyrosine Receptor Receptor-3 Receptors Research Signal Situ Surface System Targeting Transduction Vascular Vessels analysis and blood embryology genetics physiology supply by kanefendt on Feb 5, 2010, 11:28 AM
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Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia
I. Stein, A. Itin, P. Einat, R. Skaliter, Z. Grossman, and E. Keshet Mol.Cell Biol. 18(6):3112-3119 (1998)
to 3T3 A Animals Biosynthesis Cell Cells Cultured Endothelial Factor Factors Growth Humans Hypoxia Lymphokines Messenger Mice Neovascularization Oxygen Pathologic Protein RNA Rats Research Ribosomes Vascular biosynthesis cells genetics identify metabolism protein by kanefendt on Feb 5, 2010, 11:28 AM
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Proteolytic processing regulates receptor specificity and activity of VEGF-C
V. Joukov, T. Sorsa, V. Kumar, M. Jeltsch, L. Claesson-Welsh, Y. Cao, O. Saksela, N. Kalkkinen, and K. Alitalo EMBO J. 16(13):3898-3911 (1997)
to Acid Amino Animals Antibodies C Cells Cos Cultured Data Dimerization Disulfides Endopeptidases Endothelial Endothelium Factor Factors Growth Humans Kinase Kinases Laboratories Molecular Phosphorylation Post-Translational Processing Protein Protein-Tyrosine Rabbits Receptor Receptors Research Sequence Tumor Tyrosine Vascular biosynthesis cells genetics metabolism secretion by kanefendt on Feb 5, 2010, 11:28 AM
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Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets
R. Mohle, D. Green, M. A. Moore, R. L. Nachman, and S. Rafii Proc.Natl.Acad.Sci.U.S.A 94(2):663-668 (1997)
to A Alternative Blood Cell Cells Complex Cultured Cytokines Endothelial Endothelium Expression Factor Factors GPIIb-IIIa Gene Glycoprotein Growth Hematopoiesis Human Humans Immunohistochemistry Kinase Kinases Laboratories Line Lymphokines Megakaryocytes Neovascularization Physiologic Platelet Platelets Protein-Tyrosine Receptor Receptors Research Splicing Thrombin Vascular analysis cells cytology genetics metabolism pharmacology protein secretion by kanefendt on Feb 5, 2010, 11:28 AM
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VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells
J. D. Hood, C. J. Meininger, M. Ziche, and H. J. Granger Am.J.Physiol 274(3 Pt 2):H1054-H1058 (1998)
to A Calcium Capillaries Cells Cultured Dose-Response Drug Endothelial Endothelium Enzymologic Expression Factor Factors Gene Growth Human Humans Lymphokines Microcirculation Nitric Oxide Regulation Relationship Research Synthase Time Up-Regulation Vascular cells drug effects metabolism pharmacology physiology protein by kanefendt on Feb 5, 2010, 11:28 AM
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Differential binding characteristics and cellular inhibition by soluble VEGF receptors 1 and 2
W. Roeckl, D. Hecht, H. Sztajer, J. Waltenberger, A. Yayon, and H. A. Weich Exp.Cell Res. 241(1):161-170 (1998)
to & A Agents Animals BALB Binding C Cell Cells Cloning Competitive Cross-Linking Dimerization Endothelial Expression Factor Factors Fibrinolytic Gene Growth Heparin Human Humans Inbred Kinase Kinases Ligands Lymphokines Mice Mitogens Molecular Plastics Proliferation Protein Protein-Tyrosine Proteins Proto-Oncogene Reagents Receptor Receptor-1 Receptors Research Solubility Tyrosine Vascular antagonists cells drug effects genetics inhibitors isolation metabolism pharmacology protein purification by kanefendt on Feb 5, 2010, 11:28 AM
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Elevated levels of angiogenic cytokines in the plasma of cancer patients
E. Fuhrmann-Benzakein, M. N. Ma, L. Rubbia-Brandt, G. Mentha, D. Ruefenacht, A. P. Sappino, and M. S. Pepper Int.J Cancer 85(1):40-45 (2000)
to 2 A Adult Aged Cytokines Endothelial Factor Factor-alpha Factors Fibroblast Growth Hepatocyte Humans Lymphokines Middle Necrosis Neoplasms Neovascularization Pathologic Prospective Reference Research Studies Time Transforming Tumor Values Vascular beta blood cells metabolism pathology response supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Correlation of plasma and serum vascular endothelial growth factor levels with platelet count in colorectal cancer: clinical evidence of platelet scavenging?
M. L. George, S. A. Eccles, M. G. Tutton, A. M. Abulafi, and R. I. Swift Clin.Cancer Res. 6(8):3147-3152 (2000)
to 80 A Adult Aged Blood Colorectal Count Endothelial Factor Factors Female Growth Humans Lymphokines Male Middle Neoplasm Neoplasms Plasma Platelet Platelets Staging Vascular and blood cytology over pathology physiology supply surgery by kanefendt on Feb 5, 2010, 11:28 AM
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