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Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
Y. He, K. Kozaki, T. Karpanen, K. Koshikawa, S. Yla-Herttuala, T. Takahashi, and K. Alitalo J.Natl.Cancer Inst. 94(11):819-825 (2002)
to & Animals Antibodies Blotting C Cell Cells Cultured D Division Endothelial Expression Factor Factors Female Gene Growth Human Humans Kinase Kinases Laboratories Line Lung Lymph Lymphangiogenesis Lymphatic Metastasis Mice Neoplasm Neoplasms Neoplastic Nodes Protein-Tyrosine RNA Receptor Receptor-3 Receptors Regulation Research Scid Signal Time Transduction Transfection Transplantation Tumor Vascular Vessels Western antagonists blood cells control genetics immunology inhibitors metabolism methods pathology prevention protein secondary supply by kanefendt on Feb 5, 2010, 11:28 AM
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Ligand-induced vascular endothelial growth factor receptor-3 VEGFR-3 heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites
J. Dixelius, T. Makinen, M. Wirzenius, M. J. Karkkainen, C. Wernstedt, K. Alitalo, and L. Claesson-Welsh J.Biol.Chem. 278(42):40973-40979 (2003)
to Animals Binding Blood Cell Cells Chemistry Dimerization Electrophoresis Endothelial Endothelium Factor Factors Gel Growth Humans Immunoblotting Ligands Line Lymphatic Mutation Neovascularization Pathologic Peptides Phosphorylation Polyacrylamide Protein Receptor-2 Receptor-3 Research Signal Sites Structure Swine Tertiary Transduction Transfection Tyrosine Up-Regulation Vascular Vessels blood cells genetics metabolism pathology by kanefendt on Feb 5, 2010, 11:28 AM
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Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3
T. Makinen, L. Jussila, T. Veikkola, T. Karpanen, M. I. Kettunen, K. J. Pulkkanen, R. Kauppinen, D. G. Jackson, H. Kubo, S. Nishikawa, S. Yla-Herttuala, and K. Alitalo Nat.Med. 7(2):199-205 (2001)
to Animals C Cell D Endothelial Factor Factors Growth Human Humans Kinase Kinases Laboratories Line Lymph Lymphangiogenesis Lymphatic Lymphedema Mice Neovascularization Nodes Pathologic Phenotype Protein-Tyrosine Receptor Receptor-3 Receptors Research Signal Solubility Transduction Transgenic Vascular Vessels blood cells genetics metabolism pathology supply by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth
T. Karpanen, M. Egeblad, M. J. Karkkainen, H. Kubo, S. Yla-Herttuala, M. Jaattela, and K. Alitalo Cancer Res. 61(5):1786-1790 (2001)
to & Animals Blood Breast C Carcinoma Cell Division Endothelial Factor Factors Female Fusion Growth Heterologous Human Humans Immunoglobulins Kinase Kinases Laboratories Lymphangiogenesis Lymphatic Mice Neoplasm Neoplasms Neovascularization Pathologic Protein-Tyrosine Proteins Receptor Receptor-3 Receptors Recombinant Research Scid System Transfection Transplantation Vascular Vessels antagonists biosynthesis blood cells genetics inhibitors metabolism pathology physiology physiopathology protein supply by kanefendt on Feb 5, 2010, 11:28 AM
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Lymphatic endothelium: a new frontier of metastasis research
M. J. Karkkainen, T. Makinen, and K. Alitalo Nat.Cell Biol. 4(1):E2-E5 (2002)
to Biological C Cell Culture D Endothelial Endothelium Factor Factors Growth Humans Kinase Kinases Line Lymphatic Markers Metastasis Movement Neoplasm Neoplasms Neovascularization Pathologic Protein-Tyrosine Receptor Receptor-3 Receptors Research Techniques Vascular Vessels blood pathology physiology physiopathology supply by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular growth factors and lymphangiogenesis
L. Jussila, and K. Alitalo Physiol Rev. 82(3):673-700 (2002)
to A Animals Cells Endothelial Endothelium Factor Factors Growth Humans Laboratories Lymphangiogenesis Lymphatic Lymphedema Lymphokines Metastasis Research System Vascular Vessels blood cells diagnosis embryology physiology physiopathology response by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels
Y. He, I. Rajantie, K. Pajusola, M. Jeltsch, T. Holopainen, S. Yla-Herttuala, T. Harding, K. Jooss, T. Takahashi, and K. Alitalo Cancer Res. 65(11):4739-4746 (2005)
to & Adenoviridae Animals Antitumor Assays Cell Cells Endothelial Endothelium Factor Fusion Genetic Growth Humans Immunoglobulins Laboratories Line Lung Lymph Lymphangiogenesis Lymphatic Metastasis Mice Model Neoplasm Neoplasms Neovascularization Nodes Pathologic Proteins Receptor-3 Recombinant Research Scid Signal Staging Transduction Tumor Vascular Vectors Vessels Xenograft administration antagonists cells control dosage genetics inhibitors pathology physiology prevention protein therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor
J. Lin, A. S. Lalani, T. C. Harding, M. Gonzalez, W. W. Wu, B. Luan, G. H. Tu, K. Koprivnikar, M. J. VanRoey, Y. He, K. Alitalo, and K. Jooss Cancer Res. 65(15):6901-6909 (2005)
to Adenoviridae Animals C Carcinoma Cell Endothelial Factor Female Gene Genetic Growth Human Humans Kidney Line Lung Lymph Lymphangiogenesis Lymphatic Male Melanoma Metastasis Mice Neoplasms Nodes Nude Prostate Prostatic Receptor-3 Renal Techniques Therapy Transfer Tumor Vascular Vectors biosynthesis blood cells genetics immunology methods pathology secondary therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation
P. Saharinen, T. Tammela, M. J. Karkkainen, and K. Alitalo Trends Immunol. 25(7):387-395 (2004)
to Animals C Cells D Endothelial Factor Growth Homeodomain Humans Inflammation Laboratories Lymphangiogenesis Lymphatic Lymphedema Metastasis Neoplasm Proteins Receptor-3 Receptors Research Suppressor Tumor Vascular Vessels embryology metabolism physiology physiopathology protein by kanefendt on Feb 5, 2010, 11:28 AM
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Immunodetection and quantification of vascular endothelial growth factor receptor-3 in human malignant tumor tissues
H. Bando, M. Brokelmann, M. Toi, K. Alitalo, J. P. Sleeman, B. Sipos, H. J. Grone, and H. A. Weich Int.J.Cancer 111(2):184-191 (2004)
to Animals Antibodies Assay Carcinoma Cells Chemistry Cultured Distribution Endothelial Enzyme-Linked Factor Goats Growth Human Humans Immunosorbent Kidney Ligands Lung Mice Monoclonal Neoplasms Neovascularization Pathologic RANGE Receptor-3 Research Sensitivity Specificity Tissue Tumor Vascular analysis and cells diagnostic immunology methods pathology protein use by kanefendt on Feb 5, 2010, 11:28 AM
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FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines
K. Pajusola, O. Aprelikova, J. Korhonen, A. Kaipainen, L. Pertovaara, R. Alitalo, and K. Alitalo Cancer Res. 52(20):5738-5743 (1992)
to & Acid Amino Base Blood Cell Cells Chemistry Cloning Conformation Data Development Differentiation Distribution Dna Down-Regulation Embryonic Endothelial Epithelial Expression Factor Fetal Gene Growth Homology Human Humans Immunoglobulins Kinase Kinases Leukemia Line Lung Molecular Nucleic Protein Protein-Tyrosine Receptor-3 Receptors Research Sequence Species Specificity Surface Teratoma Tissue Tyrosine Vascular Vessels and blood cells genetics isolation pathology protein purification by kanefendt on Feb 5, 2010, 11:28 AM
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FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter
O. Aprelikova, K. Pajusola, J. Partanen, E. Armstrong, R. Alitalo, S. K. Bailey, J. McMahon, J. Wasmuth, K. Huebner, and K. Alitalo Cancer Res. 52(3):746-748 (1992)
to 5 Acid Adult Amino Banding Blotting Cell Chain Chromosome Chromosomes Data Dna Homology Human Humans Kidney Kinase Kinases Leukemia Lung Messenger Molecular Northern Nucleic Organ Pair Placenta Polymerase Protein-Tyrosine RNA Reaction Receptors Research Sequence Specificity Surface Tyrosine analysis cells genetics by kanefendt on Feb 5, 2010, 11:28 AM
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Endothelial receptor tyrosine kinases involved in angiogenesis
T. Mustonen, and K. Alitalo J.Cell Biol. 129(4):895-898 (1995)
to A Animals Cell Endothelial Endothelium Factor Factors Growth Kinase Kinases Laboratories Lymphokines Neoplasms Neovascularization Pathologic Protein-Tyrosine Proteins Receptor Receptor-3 Receptors Surface TIE Tyrosine Vascular blood metabolism protein supply by kanefendt on Feb 5, 2010, 11:28 AM
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Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema
M. J. Karkkainen, R. E. Ferrell, E. C. Lawrence, M. A. Kimak, K. L. Levinson, M. A. McTigue, K. Alitalo, and D. N. Finegold Nat.Genet. 25(2):153-159 (2000)
to 5 Activation Alleles Animals C Cell Chemistry Chromosomes Data Dominant Endothelial Enzyme Factor Factors Female Fusion Genes Growth Half-Life Human Humans Infant Kinase Kinases Laboratories Line Lymphedema Male Mice Missense Models Molecular Mutation Newborn Pair Pedigree Phosphorylation Protein Protein-Tyrosine Proteins Receptor Receptor-3 Receptors Recombinant Research Sequence Signal Stability Structure Surface Transcriptional Transduction Tyrosine Vascular congenital drug effects genetics metabolism pharmacology protein secondary by kanefendt on Feb 5, 2010, 11:28 AM
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Regulation of angiogenesis via vascular endothelial growth factor receptors
T. Veikkola, M. Karkkainen, L. Claesson-Welsh, and K. Alitalo Cancer Res. 60(2):203-212 (2000)
to A Animals Endothelial Factor Factors Growth Humans Kinase Kinases Laboratories Lymphokines Neoplasms Neovascularization Pathologic Physiologic Protein-Tyrosine Receptor Receptors Research Vascular blood physiology physiopathology supply by kanefendt on Feb 5, 2010, 11:28 AM
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Proteolytic processing regulates receptor specificity and activity of VEGF-C
V. Joukov, T. Sorsa, V. Kumar, M. Jeltsch, L. Claesson-Welsh, Y. Cao, O. Saksela, N. Kalkkinen, and K. Alitalo EMBO J. 16(13):3898-3911 (1997)
to Acid Amino Animals Antibodies C Cells Cos Cultured Data Dimerization Disulfides Endopeptidases Endothelial Endothelium Factor Factors Growth Humans Kinase Kinases Laboratories Molecular Phosphorylation Post-Translational Processing Protein Protein-Tyrosine Rabbits Receptor Receptors Research Sequence Tumor Tyrosine Vascular biosynthesis cells genetics metabolism secretion by kanefendt on Feb 5, 2010, 11:28 AM
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Cardiovascular failure in mouse embryos deficient in VEGF receptor-3
D. J. Dumont, L. Jussila, J. Taipale, A. Lymboussaki, T. Mustonen, K. Pajusola, M. Breitman, and K. Alitalo Science 282(5390):946-949 (1998)
to Adult Animals Antigens Blood C CD31 Cardiovascular Cell Chemistry Development Embryo Embryonic Endothelial Endothelium Factor Factors Fetal Gene Growth Hematopoiesis Heterozygote Homozygote Hybridization Immunohistochemistry In Kinase Kinases Ligands Lymphatic Mammalian Mice Neovascularization Physiologic Protein-Tyrosine Receptor Receptor-3 Receptors Research Signal Situ Surface System Targeting Transduction Vascular Vessels analysis and blood embryology genetics physiology supply by kanefendt on Feb 5, 2010, 11:28 AM
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VEGFs, receptors and angiogenesis
T. Veikkola, and K. Alitalo Semin.Cancer Biol. 9(3):211-220 (1999)
to A Animals Blood Endothelial Factor Factors Growth Humans Kinase Kinases Laboratories Lymphokines Neoplasms Neovascularization Pathologic Physiologic Protein-Tyrosine Receptor Receptors Research Vascular Vessels blood etiology physiology supply by kanefendt on Feb 5, 2010, 11:28 AM
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VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors
T. V. Petrova, P. Bono, W. Holnthoner, J. Chesnes, B. Pytowski, H. Sihto, P. Laakkonen, P. Heikkila, H. Joensuu, and K. Alitalo Cancer Cell 13(6):554-556 (2008)
to Antibodies Antibody Blood Blotting Cell Cells Chain Chemistry Cytometry Endothelial Factor Flow Growth Humans Immunohistochemistry Line Lymphatic Messenger Neoplasms Northern Polymerase RNA Reaction Receptor-3 Reproducibility Results Reverse Separation Specificity Transcriptase Tumor Vascular Vessels Western analysis blood genetics immunology methods of pathology supply by kanefendt on Feb 5, 2010, 11:28 AM
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Molecular biology and pathology of lymphangiogenesis
T. Karpanen, and K. Alitalo Annu.Rev.Pathol. (2008)
to Animal Animals Biological Biology Developmental Endothelial Endothelium Expression Factors Gene Growth Humans Laboratories Lymphangiogenesis Lymphatic Lymphedema Markers Mice Models Molecular Regulation Research System Vascular Vessels cytology genetics metabolism methods pathology by kanefendt on Feb 5, 2010, 11:28 AM
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