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Sunitinib efficacy against advanced renal cell carcinoma
R. J. Motzer, M. D. Michaelson, J. Rosenberg, R. M. Bukowski, B. D. Curti, D. J. George, G. R. Hudes, B. G. Redman, K. A. Margolin, and G. Wilding J.Urol. 178(5):1883-1887 (2007)
to & Administration Adult Aged Agents Antineoplastic Carcinoma Cell Disease Disease-Free Female Follow-Up Humans Indoles Kidney Laboratories Male Method Middle Neoplasm Neoplasms Oral Outcome Progression Pyrroles Rate Renal Research Retrospective Single-Blind Staging States Studies Survival Treatment Tyrosine United administration dosage drug epidemiology methods mortality pathology response therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
J. M. Ebos, C. R. Lee, J. G. Christensen, A. J. Mutsaers, and R. S. Kerbel Proc.Natl.Acad.Sci.U.S.A 104(43):17069-17074 (2007)
to & A Administration Agents Angiogenesis Animals Antineoplastic Antitumor Assays Blood Cell Dose-Response Drug Endothelial Factor Female Growth Humans Hypoxia Indoles Inducing Line Mice Model Neoplasms Organ Outcome Placenta Pregnancy Proteins Pyrroles RANGE Receptor-2 Relationship Research Schedule Scid Specificity Treatment Tumor Tyrosine Vascular Xenograft administration blood dosage drug effects metabolism pathology pharmacology protein response therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
H. M. Verheul, and H. M. Pinedo Nat.Rev.Cancer 7(6):475-485 (2007)
to & A Administration Agents Angiogenesis Antineoplastic Biological Blood Clinical Coagulation Drug Endothelial Factor Function Growth Humans Hypertension Inhibitors Left Models Neoplasm Platelets Research Resistance Schedule Signal Thrombosis Topic Transduction Trials Vascular Ventricular administration adverse antagonists as chemically dosage drug effects etiology induced inhibitors physiology toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Biomarkers of angiogenesis and their role in the development of VEGF inhibitors
N. Murukesh, C. Dive, and G. C. Jayson Br.J.Cancer (2009)
to Blood Growth Health Medical Oncology Plasma Pressure Prospective Research Studies blood identify response by kanefendt on Feb 5, 2010, 11:28 AM
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Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: results of a pharmacokinetic/pharmacodynamic meta-analysis
B. E. Houk, C. L. Bello, B. Poland, L. S. Rosen, G. D. Demetri, and R. J. Motzer Cancer Chemother.Pharmacol. (2009)
to Blood Carcinoma Fatigue Pressure Research adverse blood effects methods response by kanefendt on Feb 5, 2010, 11:28 AM
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Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?
T. D. Tsirlis, G. Papastratis, K. Masselou, C. Tsigris, A. Papachristodoulou, A. Kostakis, and N. I. Nikiteas World J.Gastroenterol. 14(17):2691-2701 (2008)
to Biological C Chain Colorectal D Endothelial Esophageal Factor Gastrointestinal Growth Human Humans Immunohistochemistry Inflammation Ligands Lymphangiogenesis Lymphatic Markers Metastasis Neoplasm Neoplasms Polymerase Predictive Prognosis Reaction Receptor-3 Staging Stomach System Tests Tumor Value Vascular Vessels blood metabolism mortality of pathology physiopathology surgery by kanefendt on Feb 5, 2010, 11:28 AM
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Soluble form of vascular cell adhesion molecule 1 induces migration and proliferation of vascular smooth muscle cells
H. M. Lee, H. J. Kim, K. J. Won, W. S. Choi, S. H. Park, H. Song, P. J. Park, T. K. Park, C. K. Lee, and B. Kim J.Vasc.Res. 45(3):259-268 (2008)
to & Adhesion Animals Aorta Cell Chemistry Cultured Dose-Response Drug Growth Hypertension Inbred Male Molecule-1 Movement Muscle Myocytes Phosphorylation Proliferation Rats Relationship Research SHR Signal Smooth Solubility Sprague-Dawley Transduction Tyrosine Vascular WKY administration cells cytology development dosage drug effects growth methods pathology pharmacology physiopathology response by kanefendt on Feb 5, 2010, 11:28 AM
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Method validation of protein biomarkers in support of drug development or clinical diagnosis/prognosis
J. W. Lee, and M. Hall J.Chromatogr.B Analyt.Technol.Biomed.Life Sci. (2008)
to Binding Population Prognosis RANGE States United diagnosis methods protein by kanefendt on Feb 5, 2010, 11:28 AM
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Differential binding characteristics and cellular inhibition by soluble VEGF receptors 1 and 2
W. Roeckl, D. Hecht, H. Sztajer, J. Waltenberger, A. Yayon, and H. A. Weich Exp.Cell Res. 241(1):161-170 (1998)
to & A Agents Animals BALB Binding C Cell Cells Cloning Competitive Cross-Linking Dimerization Endothelial Expression Factor Factors Fibrinolytic Gene Growth Heparin Human Humans Inbred Kinase Kinases Ligands Lymphokines Mice Mitogens Molecular Plastics Proliferation Protein Protein-Tyrosine Proteins Proto-Oncogene Reagents Receptor Receptor-1 Receptors Research Solubility Tyrosine Vascular antagonists cells drug effects genetics inhibitors isolation metabolism pharmacology protein purification by kanefendt on Feb 5, 2010, 11:28 AM
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Validation of immunoassays for bioanalysis: a pharmaceutical industry perspective
J. W. Findlay, W. C. Smith, J. W. Lee, G. D. Nordblom, I. Das, B. S. DeSilva, M. N. Khan, and R. R. Bowsher J.Pharm.Biomed.Anal. 21(6):1249-1273 (2000)
to Algorithms Antibodies Calibration Control Disease Immunoassay Molecular Progression Quality Reproducibility Results Safety Sensitivity Specificity Weight analysis and metabolism methods of protein response standards by kanefendt on Feb 5, 2010, 11:28 AM
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Calibration is the key to immunoassay but the ideal calibrator is unattainable
J. T. Whicher Scand.J.Clin.Lab Invest Suppl (1991)
to Antibodies Antigens Blood Calibration Humans Immunoassay Peptides Proteins Reference Sensitivity Specificity Standards analysis and blood immunology pathology protein standards by kanefendt on Feb 5, 2010, 11:28 AM
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"Matrix effects" in immunoassays
W. G. Wood Scand.J.Clin.Lab Invest Suppl (1991)
to & Antibodies Buffers Control Hormone Humans Immunoassay Parathyroid Quality Reference Standards Thyrotropin blood data methods numerical standards statistics by kanefendt on Feb 5, 2010, 11:28 AM
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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
J. A. Forsythe, B. H. Jiang, N. V. Iyer, F. Agani, S. W. Leung, R. D. Koos, and G. L. Semenza Mol.Cell Biol. 16(9):4604-4613 (1996)
to (Genetics) 1 40 A Acid Alignment Animals Base Binding Carcinoma Cell Cells Chemistry Cultured DNA-Binding Data Endothelial Expression Factor Factors Fusion Gene Genes Genetic Growth Hepatocellular Homology Human Humans Hypoxia Hypoxia-Inducible Liver Lymphokines Mice Molecular Neoplasms Nuclear Nucleic Promoter Proteins Rats Recombinant Regions Regulation Reporter Research Sequence Simian Subunit Transcription Transfection Tumor Vascular alpha biosynthesis cells genetics metabolism pathology physiology protein response virus by kanefendt on Feb 5, 2010, 11:28 AM
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Different efficacy of various blocking reagents to eliminate interferences by human antimouse antibodies with a two-site immunoassay
J. Reinsberg Clin.Biochem. 29(2):145-148 (1996)
to Analysis Animals Antibodies Antigen Blocking Blood CA-125 Chemical Evaluation False Heterophile Human Humans Immunoassay Indicators Mice Positive RANGE Reactions Reagents Studies Topic and as blood methods by kanefendt on Feb 5, 2010, 11:28 AM
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Comparison of Curve fitting Models for Ligand Binding Assays
Little JA (2004)
to Binding Comparison Ligand assays binding curve fitting of by kanefendt on Feb 5, 2010, 11:28 AM
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Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation
P. Saharinen, T. Tammela, M. J. Karkkainen, and K. Alitalo Trends Immunol. 25(7):387-395 (2004)
to Animals C Cells D Endothelial Factor Growth Homeodomain Humans Inflammation Laboratories Lymphangiogenesis Lymphatic Lymphedema Metastasis Neoplasm Proteins Receptor-3 Receptors Research Suppressor Tumor Vascular Vessels embryology metabolism physiology physiopathology protein by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels
Y. He, I. Rajantie, K. Pajusola, M. Jeltsch, T. Holopainen, S. Yla-Herttuala, T. Harding, K. Jooss, T. Takahashi, and K. Alitalo Cancer Res. 65(11):4739-4746 (2005)
to & Adenoviridae Animals Antitumor Assays Cell Cells Endothelial Endothelium Factor Fusion Genetic Growth Humans Immunoglobulins Laboratories Line Lung Lymph Lymphangiogenesis Lymphatic Metastasis Mice Model Neoplasm Neoplasms Neovascularization Nodes Pathologic Proteins Receptor-3 Recombinant Research Scid Signal Staging Transduction Tumor Vascular Vectors Vessels Xenograft administration antagonists cells control dosage genetics inhibitors pathology physiology prevention protein therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
D. J. Hicklin, and L. M. Ellis J.Clin.Oncol. 23(5):1011-1027 (2005)
to & A Agents Angiogenesis Animals Antibodies Antineoplastic Binding Endothelial Factor Growth Human Humans Inhibitors Ligands Neoplasms Neovascularization Pathologic Receptors Research Signal Transduction Vascular antagonists blood cells inhibitors physiology physiopathology response supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Soluble Tie2 and Flt1 extracellular domains in serum of patients with renal cancer and response to antiangiogenic therapy
A. L. Harris, P. Reusch, B. Barleon, C. Hang, N. Dobbs, and D. Marme Clin.Cancer Res. 7(7):1992-1997 (2001)
to & Aged Agents Analysis Antineoplastic Assay Binding Endothelial Enzyme-Linked Factor Female Growth Humans Immunosorbent Kidney Kinase Kinases Laboratories Male Middle Multivariate Neoplasms Neovascularization Outcome Pathologic Prognosis Protein-Tyrosine Proteins Proto-Oncogene Razoxane Receptor Receptor-1 Research Sites Solubility Survival TIE-2 Treatment Tyrosine Vascular blood control drug effects pathology prevention protein response supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Ligand-induced vascular endothelial growth factor receptor-3 VEGFR-3 heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites
J. Dixelius, T. Makinen, M. Wirzenius, M. J. Karkkainen, C. Wernstedt, K. Alitalo, and L. Claesson-Welsh J.Biol.Chem. 278(42):40973-40979 (2003)
to Animals Binding Blood Cell Cells Chemistry Dimerization Electrophoresis Endothelial Endothelium Factor Factors Gel Growth Humans Immunoblotting Ligands Line Lymphatic Mutation Neovascularization Pathologic Peptides Phosphorylation Polyacrylamide Protein Receptor-2 Receptor-3 Research Signal Sites Structure Swine Tertiary Transduction Transfection Tyrosine Up-Regulation Vascular Vessels blood cells genetics metabolism pathology by kanefendt on Feb 5, 2010, 11:28 AM
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